2-Acetylthiophene

Description

Product Name: 2-Acetylthiophene
CAS No.: 88-15-3
Chemical Name: 2-Acetylthiophene
Synonyms: Ethanone, 1-(2-thienyl)-;AKOS 91936;2-Acetylthioph;2-Acetothienone;2-Acetylthiophen;2-ACETYLTHIOLE;2-ACETOTHIOPHENE;-Acetylthiophene;2-ACETYLTHIOPHENE;AKOS BBS-00000940
CBNumber: CB5259889
Molecular Formula: C6H6OS
Formula Weight: 126.18
MOL File: 88-15-3.mol

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2-Acetylthiophene Property

Melting point:: 10-11 °C (lit.)
Boiling point:: 214 °C (lit.)
Density: 1.168 g/mL at 25 °C (lit.)
vapor pressure: 2.7 hPa (50 °C)
refractive index: n20/D 1.565(lit.)
Flash point:: 196 °F
storage temp.: Store below +30°C.
solubility: 14g/l
form: Liquid
color: Clear pale yellow to light brown
Odor: at 100.00 %. sulfurous nutty hazelnut walnut
Odor Type: sulfurous
Water Solubility: Insoluble in water.
Sensitive: Light Sensitive
BRN: 107910
InChIKey: WYJOVVXUZNRJQY-UHFFFAOYSA-N
LogP: 1.250
CAS DataBase Reference: 88-15-3(CAS DataBase Reference)
NIST Chemistry Reference: Ethanone, 1-(2-thienyl)-(88-15-3)
EPA Substance Registry System: Ethanone, 1-(2-thienyl)- (88-15-3)

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 25-23/24/25-20/21/22
Safety Statements: 45-38-36/37/39-28-36
RIDADR: UN 2810 6.1/PG 2
WGK Germany: 3
RTECS: OB6300000
F: 13
Autoignition Temperature: 265 °C DIN 51794
Hazard Note: Irritant
TSCA: Yes
HazardClass: 6.1
PackingGroup: II
HS Code: 29349990
Toxicity: LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H311Toxic in contact with skin

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A22602
Product name: 2-Acetylthiophene
Purity: 98%
Packaging: 25g
Price: $38
Updated: 2023/06/20

Sigma-Aldrich

Product number: W503509
Product name: 2-Acetylthiophene
Purity: ≥98%, FG
Packaging: 250g
Price: $173
Updated: 2023/06/20

Sigma-Aldrich

Product number: W503509
Product name: 2-Acetylthiophene
Purity: ≥98%, FG
Packaging: 1kg
Price: $521
Updated: 2023/01/07

Sigma-Aldrich

Product number: 8.00175
Product name: 2-Acetylthiophene
Purity: for synthesis
Packaging: 50mL
Price: $110
Updated: 2023/01/07

Sigma-Aldrich

Product number: 8.00175
Product name: 2-Acetylthiophene
Purity: for synthesis
Packaging: 250ML
Price: $450
Updated: 2023/01/07

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2-Acetylthiophene Chemical Properties,Usage,Production

Description

2-Acetylthiophene occurs naturally in kohlrabi. It has a sulfurous nutty hazelnut odor. It can be used as a food additive. It is also used as an intermediate to produce drugs, such as Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc.

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2-Acetylthiophene(2AT) is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. 2AT is used as an important precursor to thiophene-2-acetic acid (T2AA) or its acid chloride (Cl) and thiophene-2-carboxylic acid (T2CA) (Cl). It is important that the process used to synthesize 2AT yields the lowest amount of 3- acetylthiophene isomer.

Definition

ChEBI: 2-Acetylthiophene is an aromatic ketone.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 8, 1943
The Journal of Organic Chemistry, 36, p. 540, 1971 DOI: 10.1021/jo00803a011
Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1

Safety Profile

Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,.

Purification Methods

Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.]

2-Acetylthiophene Preparation Products And Raw materials

Raw materials

Acetyl chloride

Preparation Products

5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE 1-(4-BROMO-2-THIENYL)ETHAN-1-ONE 5-THIEN-2-YL-4H-PYRAZOLE-3-CARBOXYLIC ACID Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate N-(2-THIOPHENECARBOMYL)PYRIDINIUM BROMIDE 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER 4-Bromo-2-thiophenecarboxylic acid 5-ACETYL-2-THIOPHENECARBALDEHYDE 2-Thiopheneacetic acid 2-(2-BROMOACETYL)THIOPHENE 2-(2-thienyl)propionic acid 1-[2-Hydroxy-2(2-thienyl)ethyl]pyridinium bromide 2,4-DIOXO-4-THIOPHEN-2-YL-BUTYRIC ACID METHYL ESTER THIOPHENE-2-ACETAMIDE

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2-Acetylthiophene Suppliers

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View Lastest Price from 2-Acetylthiophene manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 2-ACETYLTHIOPHENE 88-15-3
Price: US $1.00/PCS
Min. Order: 1PCS
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-10-30

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Acetylthiophene 88-15-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

Hebei Yanxi Chemical Co., Ltd.

Product: 2-Acetylthiophene 88-15-3
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-09-11

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