Description
ChemicalBook > CAS DataBase List > 2-Acetylthiophene

2-Acetylthiophene

Description
Product Name
2-Acetylthiophene
CAS No.
88-15-3
Chemical Name
2-Acetylthiophene
Synonyms
Ethanone, 1-(2-thienyl)-;AKOS 91936;2-Acetylthioph;2-Acetothienone;2-Acetylthiophen;2-ACETYLTHIOLE;2-ACETOTHIOPHENE;-Acetylthiophene;2-ACETYLTHIOPHENE;AKOS BBS-00000940
CBNumber
CB5259889
Molecular Formula
C6H6OS
Formula Weight
126.18
MOL File
88-15-3.mol
More
Less

2-Acetylthiophene Property

Melting point:
10-11 °C (lit.)
Boiling point:
214 °C (lit.)
Density 
1.168 g/mL at 25 °C (lit.)
vapor pressure 
2.7 hPa (50 °C)
refractive index 
n20/D 1.565(lit.)
Flash point:
196 °F
storage temp. 
Store below +30°C.
solubility 
14g/l
form 
Liquid
color 
Clear pale yellow to light brown
Odor
at 100.00 %. sulfurous nutty hazelnut walnut
Odor Type
sulfurous
Water Solubility 
Insoluble in water.
Sensitive 
Light Sensitive
BRN 
107910
InChIKey
WYJOVVXUZNRJQY-UHFFFAOYSA-N
LogP
1.250
CAS DataBase Reference
88-15-3(CAS DataBase Reference)
NIST Chemistry Reference
Ethanone, 1-(2-thienyl)-(88-15-3)
EPA Substance Registry System
Ethanone, 1-(2-thienyl)- (88-15-3)
More
Less

Safety

Hazard Codes 
T,Xi,Xn
Risk Statements 
25-23/24/25-20/21/22
Safety Statements 
45-38-36/37/39-28-36
RIDADR 
UN 2810 6.1/PG 2
WGK Germany 
3
RTECS 
OB6300000
F 
13
Autoignition Temperature
265 °C DIN 51794
Hazard Note 
Irritant
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29349990
Toxicity
LD50 orally in Rabbit: 25 - 200 mg/kg LD50 dermal Rat 370 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H311Toxic in contact with skin

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A22602
Product name
2-Acetylthiophene
Purity
98%
Packaging
25g
Price
$38
Updated
2023/06/20
Sigma-Aldrich
Product number
W503509
Product name
2-Acetylthiophene
Purity
≥98%, FG
Packaging
250g
Price
$173
Updated
2023/06/20
Sigma-Aldrich
Product number
W503509
Product name
2-Acetylthiophene
Purity
≥98%, FG
Packaging
1kg
Price
$521
Updated
2023/01/07
Sigma-Aldrich
Product number
8.00175
Product name
2-Acetylthiophene
Purity
for synthesis
Packaging
50mL
Price
$110
Updated
2023/01/07
Sigma-Aldrich
Product number
8.00175
Product name
2-Acetylthiophene
Purity
for synthesis
Packaging
250ML
Price
$450
Updated
2023/01/07
More
Less

2-Acetylthiophene Chemical Properties,Usage,Production

Description

2-Acetylthiophene occurs naturally in kohlrabi. It has a sulfurous nutty hazelnut odor. It can be used as a food additive. It is also used as an intermediate to produce drugs, such as Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc.

Chemical Properties

clear colorless to slightly yellow liquid

Uses

2-Acetylthiophene(2AT) is used as an intermediate in the manufacturing of drugs like Tiamonium Iodide, Suprofan, Stepronin, Tenonitrozole, Namirotene, etc. 2AT is used as an important precursor to thiophene-2-acetic acid (T2AA) or its acid chloride (Cl) and thiophene-2-carboxylic acid (T2CA) (Cl). It is important that the process used to synthesize 2AT yields the lowest amount of 3- acetylthiophene isomer.

Definition

ChEBI: 2-Acetylthiophene is an aromatic ketone.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 2, p. 8, 1943
The Journal of Organic Chemistry, 36, p. 540, 1971 DOI: 10.1021/jo00803a011
Tetrahedron Letters, 40, p. 3109, 1999 DOI: 10.1016/S0040-4039(99)00476-1

Safety Profile

Poison by intraperitoneal route. A flammable liquid. When heated to decomposition emits toxic fumes of SOx,.

Purification Methods

Fractionally distil the thiophene through a 12-plate column, and fraction b 77o/4mm is collected. Also wet the acetylthiophene in order to remove and free thiophene which forms an azeotrope with H2O, b 68o. Store it in a brown bottle, and the clear colourless liquid remains thus for extended periods. [Kosak & Hartough Org Synth Coll Vol III 14 1955, Hartough & Kosak J Am Chem Soc 69 3093 1947.] The red 4-nitrophenylhydrazone crystallises from EtOH with m 181-182o. [Beilstein 17/9 V 387.]

2-Acetylthiophene Preparation Products And Raw materials

Raw materials

Acetyl chloride

Preparation Products

5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE 1-(4-BROMO-2-THIENYL)ETHAN-1-ONE 5-THIEN-2-YL-4H-PYRAZOLE-3-CARBOXYLIC ACID Ethyl 5-thien-2-yl-1H-pyrazole-3-carboxylate N-(2-THIOPHENECARBOMYL)PYRIDINIUM BROMIDE 3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER 4-Bromo-2-thiophenecarboxylic acid 5-ACETYL-2-THIOPHENECARBALDEHYDE 2-Thiopheneacetic acid 2-(2-BROMOACETYL)THIOPHENE 2-(2-thienyl)propionic acid 1-[2-Hydroxy-2(2-thienyl)ethyl]pyridinium bromide 2,4-DIOXO-4-THIOPHEN-2-YL-BUTYRIC ACID METHYL ESTER THIOPHENE-2-ACETAMIDE
More
Less

2-Acetylthiophene Suppliers

Americas 1 Belgium 3 Canada 2 China 475 Europe 4 France 4 Germany 14 Hungary 1 India 86 Italy 2 Japan 7 Russia 1 Slovakia 1 South Korea 2 Switzerland 2 The Netherlands 1 United Kingdom 22 United States 64 USA 1 Global 693
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
Advantage
58
Anisyn, Inc.
Tel
--
Fax
--
Email
sales@anisyn.com
Country
United States
ProdList
863
Advantage
0
Barath Biosciences, Inc.
Tel
--
Fax
--
Email
barath@barathbiosciences.com
Country
United States
ProdList
203
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
PearlChem Corporation
Tel
--
Fax
--
Email
info@pearlchemcorp.com
Country
United States
ProdList
131
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Synerzine, Inc. (formerly Pyrazine Specialties, Inc. and CTC Organics)
Tel
--
Fax
--
Email
info@synerzine.com
Country
United States
ProdList
314
Advantage
58
QV Chemicals LLC
Tel
--
Fax
--
Email
info@qvchemicals.com
Country
United States
ProdList
257
Advantage
50
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
Beijing Lys Chemicals Co, LTD.
Tel
--
Fax
--
Email
jiayanyong@lyschem.com
Country
United States
ProdList
710
Advantage
58
Jiangyin Healthway International Trade Co., Ltd
Tel
--
Fax
--
Email
info@healthwaychem.com
Country
United States
ProdList
1006
Advantage
58
M&U International LLC
Tel
--
Fax
--
Email
sales@mu-intel.com
Country
United States
ProdList
2011
Advantage
58
WholeChem, LLC
Tel
--
Fax
--
Email
info@wholechem.com
Country
United States
ProdList
814
Advantage
58
Qingdao Free Trade Zone United International Co Ltd
Tel
--
Fax
--
Email
info@unitedint.com
Country
United States
ProdList
604
Advantage
58
Lluch Essence S.L.
Tel
--
Fax
--
Email
web@lluche.com
Country
United States
ProdList
2352
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
R C Treatt and Co Ltd
Tel
--
Fax
--
Email
enquiries@treatt.com
Country
United States
ProdList
1690
Advantage
58
Pyrazine Specialties, Inc.
Tel
--
Fax
--
Country
United States
ProdList
1265
Advantage
30
OQEMA
Tel
--
Fax
--
Email
fandf@oqema.co.uk
Country
United States
ProdList
578
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
DeLong Chemicals America
Tel
--
Fax
--
Email
sales@delongchemicals.com
Country
United States
ProdList
529
Advantage
50
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
LANXESS Corporation
Tel
--
Fax
--
Email
info@LANXESS.com
Country
United States
ProdList
262
Advantage
57
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Parish Chemical Company
Tel
--
Fax
--
Country
United States
ProdList
1248
Advantage
47
Advanced Synthesis Technologies
Tel
--
Fax
--
Email
sales@advancedsynthesis.com
Country
United States
ProdList
4775
Advantage
61
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
Sinova Inc.
Tel
--
Fax
--
Email
sales@sinovainc.com
Country
United States
ProdList
4009
Advantage
58
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
City Chemical LLC
Tel
--
Fax
--
Email
sales@citychemical.com
Country
United States
ProdList
6708
Advantage
72
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
M/S PANAMIT INTERNATIONAL
Tel
--
Fax
--
Email
sales@jyotichem.com
Country
United States
ProdList
312
Advantage
46
Kingchem Inc.
Tel
--
Fax
--
Email
s.wang@kingchem.com
Country
United States
ProdList
757
Advantage
60
Leonid Chemicals Private Limited
Tel
--
Fax
--
Email
careers@leonidchemicals.com
Country
United States
ProdList
1700
Advantage
43
More
Less

View Lastest Price from 2-Acetylthiophene manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
2-ACETYLTHIOPHENE 88-15-3
Price
US $1.00/PCS
Min. Order
1PCS
Purity
99%
Supply Ability
10 mt
Release date
2024-10-30
Hebei Weibang Biotechnology Co., Ltd
Product
2-Acetylthiophene 88-15-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-30
Hebei Yanxi Chemical Co., Ltd.
Product
2-Acetylthiophene 88-15-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-11

88-15-3, 2-AcetylthiopheneRelated Search:

N-ACETYL-L-TYROSINE ETHYL ESTER Paraquat dichloride Methyl acrylate Kresoxim-methyl Methanol Acetyl chloride Acetylferrocene Acetonitrile Acetylacetone Thiophene Methylparaben Methyl acetate Tetraacetylethylenediamine Basic Violet 1 Methyl Acetylpyrazine 2-Acetylfuran 2-Acetylthiazole

  • 1-(2-THIENYL)ETHAN-1-ONE
  • AKOS BBS-00000940
  • AKOS 91936
  • 2-ACETYLTHIOLE
  • 2-ACETYLTHIOPHENE
  • 2-ACETOTHIOPHENE
  • LABOTEST-BB LT01593557
  • METHYL 2-THIENYL KETONE
  • 2-ACETYLTHIOPHENE 98+%
  • 2-Acetylthiophene99%
  • acetylthiophene,2-acetylthiophene
  • Ethanone, 1-(2-thienyl)-
  • 2-ACETYLBROMOTHIOPHENE
  • 1-(2-Thienyl)-1-ethanone
  • 1-(Thien-2-yl)ethan-1-one
  • 2-Acetylthiophene, 98% 100GR
  • METHYL 2-THIENYL KETONE FOR SYNTHESIS
  • 1-(2-thienyl)-ethanon
  • 1-thiophen-2-yl-ethanone
  • 2-acethylthiophene
  • 2-Acetothienone
  • 2-Acetylthiophen
  • 2-Thienyl methyl ketone
  • 2-thienylmethylketone
  • alpha-acetylthiophene
  • Ketone, methyl 2-thienyl
  • ketone,methyl2-thienyl
  • thiophene,2-acetyl-
  • 2 - thiophene ethyl ketone
  • 2-Acetylthioph
  • 2-Acetylthiophene in stock Factory
  • 2-Acetylthiophene &gt
  • High Quality 2-Acetylthiophene
  • 2-Acetylthiophene USP/EP/BP
  • 2-Acetylthiophene (Stellar-2002)
  • 2-Acetyl Thiophene pure, 99%
  • Avatrombopag Impurity 95
  • -Acetylthiophene
  • 5-BROMO-4-(THIOPHEN-2-YL)-1,3-THIAZOL-2-AMINE
  • Acetonitrile Dried Special
  • 2-Acetylthiophene 98% For Synthesis
  • Aficamten Impurity 11
  • Methyl-2-thienylketon
  • 88-15-3
  • 8-15-3
  • CH3COC4H3S
  • Thiophenes
  • Heterocyclic Building Blocks
  • KETONE
  • Building Blocks
  • Heterocycle-oher series
  • Sulphur Derivatives
  • Thiophene&Benzothiophene
  • thiophene Flavor
  • Thiophenes
  • 1
  • bc0001