ChemicalBook > CAS DataBase List > ASC-J9

ASC-J9

Product Name: ASC-J9
CAS No.: 52328-98-0
Chemical Name: ASC-J9
Synonyms: GO-Y 025;Indiscriminate;Dimethylcurcumin;Dimethylcurcumin, ≥95%;Dimethylcurcumin (ASC-J9);4',4"-O,O-DIMETHYLCURCUMIN-D6;Dimethylcurcumin, 10 mM in DMSO;1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one;1,4,6-Heptatrien-3-one, 1,7-bis(3,4-diMethoxyphenyl)-5-hydroxy-,(1E,4Z,6E)-
CBNumber: CB52624078
Molecular Formula: C23H24O6
Formula Weight: 396.43
MOL File: 52328-98-0.mol

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ASC-J9 Property

Melting point:: 129-130℃
Boiling point:: 588.6±50.0 °C(Predicted)
Density: 1.191
storage temp.: Store at -20°C
solubility: insoluble in EtOH; insoluble in H2O; ≥16.65 mg/mL in DMSO
form: solid
pka: 8.34±0.60(Predicted)
color: Light yellow to red
InChI: InChI=1S/C23H24O6/c1-26-20-11-7-16(13-22(20)28-3)5-9-18(24)15-19(25)10-6-17-8-12-21(27-2)23(14-17)29-4/h5-15,24H,1-4H3/b9-5+,10-6+,18-15-
InChIKey: ZMGUKFHHNQMKJI-CIOHCNBKSA-N
SMILES: C(/C1=CC=C(OC)C(OC)=C1)=C\C(=O)/C=C(\O)/C=C/C1=CC=C(OC)C(OC)=C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3413
Product name: ASC-J9
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $63.27
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3413
Product name: ASC-J9
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $268
Updated: 2025/07/31

Cayman Chemical

Product number: 10008187
Product name: Dimethylcurcumin
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 10008187
Product name: Dimethylcurcumin
Purity: ≥95%
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Cayman Chemical

Product number: 10008187
Product name: Dimethylcurcumin
Purity: ≥95%
Packaging: 10mg
Price: $341
Updated: 2024/03/01

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ASC-J9 Chemical Properties,Usage,Production

Chemical Properties

Soluble in organic solvents such as methanol, ethanol, and DMSO.

Uses

Dimethylcurcumin selectively enhances the degradation of androgen receptor. Dimethylcurcumin is a related compound of Curcumin (C838500).

Biological Activity

asc-j9, is antitumor agent. asc-j9 suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors targeting both far- and ar3-mediated pca growth by asc-j9 may represent the novel therapeutic approach to suppress castration-resistant pca. asc-j9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor.the androgen receptor (ar) is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. [1]the binding of an androgen to the androgen receptor(ar) results into a conformational change, in turn, which causes dissociation of hsp, transport from the cytosol into the cell nucleus, and dimerization. the ar dimer binds to a specific sequence of dna known as hre which can interact with other proteins in the nucleus, leading to up-regulation or down-regulation of specific gene transcription.[2]asc-j9, the ar degradation enhancer, suppressed both macrophage migration and subsequent pca cell invasion. additionally, asc-j9 can regulate pstat3-ccl2 signaling using two pathways: an ar-dependent pathway via inhibiting pias3 expression and an ar-independent pathway via direct inhibition of the stat3 phosphorylation/activation through mouse model in vivo with orthotopically injected tramp-c1 cells. in conclusion,a new and better therapeutic strategies using asc-j9 alone or a combinational therapy that simultaneously targets androgens/ar signaling and pias3-pstat3-ccl2 signaling to better battle pca growth and metastasis at castration-resistant stage.[3]1. lu nz. et al. "international union of pharmacology. lxv. the pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors". pharmacol. rev. 2006, 58 (4): 782–97.2. heemers hv, tindall dj. "androgen receptor (ar) coregulators: a diversity of functions converging on and regulating the ar transcriptional complex". endocr. rev. 2007, 28 (7): 778–808.3. lin th. et al. “anti-androgen receptor asc-j9 versus anti-androgens mdv3100 (enzalutamide) or casodex (bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and stat3-ccl2 signaling.” cell deathdis. 2013,4:e764

in vivo

Dimethylcurcumin (ASC-J9) (75 mg/kg, i.p.) degrades both fAR and AR3 in the xenografted tumors in vivo, and SC-J9-treated tumors has significantly decreased Ki67-positive cells^[1]. Dimethylcurcumin (ASC-J9) (50 mg/kg every 48 h, i.p.) substantially ameliorates the SBMA symptoms in AR-97Q mice, and ameliorates neuromuscular pathological findings. The Dimethylcurcumin (ASC-J9)-treated SBMA mice have relatively normal serum testosterone concentrations^[2]. ASC-J9-treated mice show significantly smaller prostate tumor sizes when compared with those receiving classic ADT/castration with little serum androgen^[3].

ASC-J9 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASC-J9 Suppliers

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View Lastest Price from ASC-J9 manufacturers

Career Henan Chemical Co

Product: ASC-J9;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one 52328-98-0
Price: US $2.00/KG
Min. Order: 1KG
Purity: 95.0-99.8%
Supply Ability: 1KG;5KG 10KG; 100KG
Release date: 2019-09-02

52328-98-0, ASC-J9Related Search:

N,N-Dimethylacetamide N,N-Dimethylaniline POLY(DIMETHYLSILOXANE), HYDROXY TERMINATED (3S,5S)-1,7-BIS(4-HYDROXY-3-METHOXYPHENYL)HEPTANE-3,5-DIOL FLLL31 HEXAHYDROCURCUMIN DEMETHOXYCURCUMIN Tetrahydrocurcumin BIS(4-HYDROXYCINNAMOYL)METHANE 5"-MethoxyhexahydrocurcuMin DihydrocurcuMin Curcumin

1,4,6-Heptatrien-3-one, 1,7-bis(3,4-diMethoxyphenyl)-5-hydroxy-,(1E,4Z,6E)-

(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one (ASC-J9)

(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one

Dimethylcurcumin

GO-Y 025

Dimethylcurcumin, ≥95%

Dimethylcurcumin【(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one】

Indiscriminate

4',4"-O,O-DIMETHYLCURCUMIN-D6

1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one

Dimethylcurcumin, 10 mM in DMSO

Dimethylcurcumin (ASC-J9)

52328-98-0