ASC-J9
- Product Name
- ASC-J9
- CAS No.
- 52328-98-0
- Chemical Name
- ASC-J9
- Synonyms
- GO-Y 025;Indiscriminate;Dimethylcurcumin;Dimethylcurcumin, ≥95%;4',4"-O,O-DIMETHYLCURCUMIN-D6;1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one;1,4,6-Heptatrien-3-one, 1,7-bis(3,4-diMethoxyphenyl)-5-hydroxy-,(1E,4Z,6E)-;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one (ASC-J9);Dimethylcurcumin【(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one】
- CBNumber
- CB52624078
- Molecular Formula
- C23H24O6
- Formula Weight
- 396.43
- MOL File
- 52328-98-0.mol
ASC-J9 Property
- Melting point:
- 129-130℃
- Boiling point:
- 588.6±50.0 °C(Predicted)
- Density
- 1.191
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; insoluble in H2O; ≥16.65 mg/mL in DMSO
- form
- solid
- pka
- 8.34±0.60(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML3413
- Product name
- ASC-J9
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $64.8
- Updated
- 2024/03/01
- Product number
- SML3413
- Product name
- ASC-J9
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $261
- Updated
- 2024/03/01
- Product number
- 10008187
- Product name
- Dimethylcurcumin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 10008187
- Product name
- Dimethylcurcumin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $193
- Updated
- 2024/03/01
- Product number
- 10008187
- Product name
- Dimethylcurcumin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $341
- Updated
- 2024/03/01
ASC-J9 Chemical Properties,Usage,Production
Uses
Dimethylcurcumin selectively enhances the degradation of androgen receptor. Dimethylcurcumin is a related compound of Curcumin (C838500).
Biological Activity
asc-j9, is antitumor agent. asc-j9 suppresses castration-resistant prostate cancer growth via degradation of full-length and splice variant androgen receptors targeting both far- and ar3-mediated pca growth by asc-j9 may represent the novel therapeutic approach to suppress castration-resistant pca. asc-j9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor.the androgen receptor (ar) is a type of nuclear receptor that is activated by binding either of the androgenic hormones, testosterone, or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. [1]the binding of an androgen to the androgen receptor(ar) results into a conformational change, in turn, which causes dissociation of hsp, transport from the cytosol into the cell nucleus, and dimerization. the ar dimer binds to a specific sequence of dna known as hre which can interact with other proteins in the nucleus, leading to up-regulation or down-regulation of specific gene transcription.[2]asc-j9, the ar degradation enhancer, suppressed both macrophage migration and subsequent pca cell invasion. additionally, asc-j9 can regulate pstat3-ccl2 signaling using two pathways: an ar-dependent pathway via inhibiting pias3 expression and an ar-independent pathway via direct inhibition of the stat3 phosphorylation/activation through mouse model in vivo with orthotopically injected tramp-c1 cells. in conclusion,a new and better therapeutic strategies using asc-j9 alone or a combinational therapy that simultaneously targets androgens/ar signaling and pias3-pstat3-ccl2 signaling to better battle pca growth and metastasis at castration-resistant stage.[3]1. lu nz. et al. "international union of pharmacology. lxv. the pharmacology and classification of the nuclear receptor superfamily: glucocorticoid, mineralocorticoid, progesterone, and androgen receptors". pharmacol. rev. 2006, 58 (4): 782–97.2. heemers hv, tindall dj. "androgen receptor (ar) coregulators: a diversity of functions converging on and regulating the ar transcriptional complex". endocr. rev. 2007, 28 (7): 778–808.3. lin th. et al. “anti-androgen receptor asc-j9 versus anti-androgens mdv3100 (enzalutamide) or casodex (bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and stat3-ccl2 signaling.” cell deathdis. 2013,4:e764
ASC-J9 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ASC-J9 manufacturers
- Product
- ASC-J9;(1E,4Z,6E)-1,7-Bis(3,4-dimethoxyphenyl)-5-hydroxy-1,4,6-heptatrien-3-one 52328-98-0
- Price
- US $1.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 95.0-99.8%
- Supply Ability
- 1KG;5KG 10KG; 100KG
- Release date
- 2019-09-02