3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- Product Name
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- CAS No.
- 420831-40-9
- Chemical Name
- 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
- Synonyms
- AK-7;CS-922;AK 7, >=98%;AK-7?, ≥99%;AK-7;AK7;AK 7;SIRT2 Inhibitor II;AK-7, 10 mM in DMSO;SIRT2 Inhibitor,AK-7;SIRT2 Inhibitor II, AK-7;SIRT2 INHIBITOR II;AK7;AK 7
- CBNumber
- CB52639218
- Molecular Formula
- C19H21BrN2O3S
- Formula Weight
- 437.35
- MOL File
- 420831-40-9.mol
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Property
- Density
- 1.469±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥15mg/mL
- form
- powder
- pka
- 12.28±0.70(Predicted)
- color
- white to tan
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
- InChIKey
- IYAYHZZWYNXHEQ-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=CC(Br)=C1)(=O)C1=CC=CC(S(N2CCCCCC2)(=O)=O)=C1
N-Bromosuccinimide Price
- Product number
- SML0152
- Product name
- AK-7
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $101
- Updated
- 2025/07/31
- Product number
- SML0152
- Product name
- AK-7
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $275.8
- Updated
- 2025/07/31
- Product number
- 14004
- Product name
- AK-7
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 14004
- Product name
- AK-7
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $138
- Updated
- 2024/03/01
- Product number
- 14004
- Product name
- AK-7
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $324
- Updated
- 2024/03/01
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Chemical Properties,Usage,Production
Description
The sirtuin SIRT2 is a deacetylase which targets α-
Uses
AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor.
in vivo
AK-7 (15 mg/kg/dose, i.p.) is brain-permeable in wild-type and HD mice[1]. AK-7 (10, 20 mg/kg, i.p.) improves the behavior and neuropathological phenotype and extends survival of R6/2 HD mice. AK-7 (20 mg/kg) ameliorates HD neuropathology in R6/2 mice. AK-7 also reduces the polyglutamine aggregation in R6/2 brain. In addition, AK-7 treated 140CAG mice show motor performance changes that parallel untreated wild-type mice, with the 20 mg/kg dose being most effective and significantly different from untreated 140CAG mice[2].
IC 50
SIRT2: 15.5 μM (IC50)
storage
+4°C
References
[1] DAVID M. TAYLOR. A Brain-Permeable Small Molecule Reduces Neuronal Cholesterol by Inhibiting Activity of Sirtuin 2 Deacetylase[J]. ACS Chemical Biology, 2011, 6 6: 540-546. DOI:10.1021/cb100376q
[2] VANITA CHOPRA. The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models.[J]. Cell reports, 2012, 2 6: 1492-1497. DOI:10.1016/j.celrep.2012.11.001
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Preparation Products And Raw materials
Raw materials
Preparation Products
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Suppliers
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- The Netherlands
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