ChemicalBook > CAS DataBase List > 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide

3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide

Product Name
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
CAS No.
420831-40-9
Chemical Name
3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
Synonyms
AK-7;CS-922;AK 7, >=98%;AK-7;AK7;AK 7;SIRT2 Inhibitor II;SIRT2 Inhibitor,AK-7;SIRT2 Inhibitor II, AK-7;SIRT2 INHIBITOR II;AK7;AK 7;3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide;N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
CBNumber
CB52639218
Molecular Formula
C19H21BrN2O3S
Formula Weight
437.35
MOL File
420831-40-9.mol
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3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Property

Density 
1.469±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
DMSO: ≥15mg/mL
form 
powder
pka
12.28±0.70(Predicted)
color 
white to tan
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0152
Product name
AK-7
Purity
≥98% (HPLC)
Packaging
5mg
Price
$116
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0152
Product name
AK-7
Purity
≥98% (HPLC)
Packaging
25mg
Price
$451
Updated
2024/03/01
Cayman Chemical
Product number
14004
Product name
AK-7
Purity
≥95%
Packaging
5mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
14004
Product name
AK-7
Purity
≥95%
Packaging
10mg
Price
$138
Updated
2024/03/01
Cayman Chemical
Product number
14004
Product name
AK-7
Purity
≥95%
Packaging
25mg
Price
$324
Updated
2024/03/01
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3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Chemical Properties,Usage,Production

Description

The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo.

Uses

AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor.

storage

+4°C

References

1) Tylor et al. (2011), A brain-permeable small molecule that reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase; ACS Chem. Biol., 6 540 2) Chopra et al. (2012), The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models; Cell Rep., 2 1492

3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Suppliers

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420831-40-9, 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMideRelated Search:

EPA C2 CERAMIDE Lovastatin LY 171883 N-Methylformamide FORMANILIDE 4-Aminodiphenylamine

  • N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide
  • SIRT2 Inhibitor,AK-7
  • N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7
  • SIRT2 Inhibitor II
  • SIRT2 INHIBITOR II;AK7;AK 7
  • AK 7, >=98%
  • 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide
  • AK-7
  • CS-922
  • SIRT2 Inhibitor II, AK-7
  • AK-7;AK7;AK 7
  • Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-
  • 420831-40-9