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Copper tripeptide

Product Name
Copper tripeptide
CAS No.
89030-95-5
Chemical Name
Copper tripeptide
Synonyms
Copper tripeptide;GHK Copper;DEXM74;Ghk-Cu;DEX M 74;DEX M-74;DEX-M-74;GHK.CU.HAC;GHK-Cu (1:1);Ghk-Cu/AHK-CU
CBNumber
CB52651405
Molecular Formula
C14H21CuN6O4
Formula Weight
400.91
MOL File
89030-95-5.mol
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Copper tripeptide Property

storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Soluble in DMSO
Sequence
(Cu2+ )H-Glu-His-Lys-OH
InChI
InChI=1/C14H23N6O4.Cu/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9;/h7-8,10-11,16H,1-6,15H2,(H4,17,18,19,20,21,22,23,24);/q-1;+3/p-2/t10-,11-;/s3
InChIKey
DDNUEECOCUBKBT-MIIMWFGWNA-L
SMILES
C([C@@H]1CC2=CNC=N2[Cu+2]2NCC(=O)[N-]12)(=O)N[C@H](C(=O)[O-])CCCCN |&1:1,16,r|
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
C685438
Product name
CopperPeptide(GHK-Cu)
Packaging
500mg
Price
$130
Updated
2021/12/16
ChemScene
Product number
CS-0015088
Product name
Coppertripeptide
Purity
99.40%
Packaging
500mg
Price
$130
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC138108
Product name
Copper peptide(GHK-Cu)
Packaging
2g
Price
$170
Updated
2021/12/16
ChemScene
Product number
CS-0015088
Product name
Coppertripeptide
Purity
99.40%
Packaging
250mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC138108
Product name
Copper peptide(GHK-Cu)
Packaging
1g
Price
$90
Updated
2021/12/16
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Copper tripeptide Chemical Properties,Usage,Production

Description

Copper tripeptide, also known as [N2-(N-Glycyl-L-histidyl)-L-lysinato(2-)]copper or GHK-Cu, is a naturally occurring tripeptide. It was first isolated from human plasma but can be found in saliva and urine. During wound healing, it may be freed from existing extracellular proteins via proteolysis. Studies have shown that GHK-Cu has a maximal biological effect at 10-9 mol/L and Its concentration in the body decreases with age[1].

Uses

Copper tripeptide (GHK-Cu) can be used as a skin antiaging agent. It could lead to the extracellular matrix accumulation increases in the rat wound model. Copper Peptide preparations were able to promote wound healing rates in diabetic ulcers and patients undergoing Mohs surgery. It could induce angiogenesis in rabbit models at 10?12 mol/L by acting as a chemoattractant for capillary cells. It may also improve the autocrine growth factor milieu in keloid fibroblasts[1-2]. It can also be doped into It can also be doped into binary binary PBDB-T: ITIC to tune the crystallinity and phase separation of the active layer, improving the performance of polymer solar cells[3].

Mechanism of action

At this concentration (10-9 mol/L), GHK-Cu has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. It has been demonstrated that GHK-Cu stimulates cultured normal fibroblasts to synthesize collagen and induces a dose-dependent increase in the synthesis of glycosaminoglycans. It could stimulate the regeneration of skin, nervous tissue, bones, lungs, and liver, protect the liver from oxidative damage, restore the activity of irradiated fibroblasts, reduce inflammation, and increase levels of antioxidant enzymes[1].

Side effects

Copper tripeptide (GHK-Cu) is considered to be very safe but there are always a few side effects related to any substance that is taken for health. When using creams, you might have mild skin irritation if you are one of the very few people with sensitivity. When the substance has been injected, people have reported that they experience cramping and burning at the injection site.
Other reported side effects are: Headache; Dizziness; Fatigue; Nausea; Elevated blood pressure; Lowered blood pressure; Increase in appetite; Redness and pain at the injection site; Cramping at the injection site.

References

[1] Jeffrey D, et al. Effects of Copper Tripeptide on the Growth and Expression of Growth Factors by Normal and Irradiated Fibroblasts. Archives of Facial Plastic Surgery, 2005; 7.
[2] Huang J, et al. Efficient Ternary Polymer Solar Cells with Tunable Crystallinity and Phase Separation of Active Layers via Incorporating GHK-Cu. ACS Applied Materials Interfaces, 2021; 13: 46927–46937.
[3] Pickart L, et al.Modulation of Gene Expression in Human Breast Cancer MCF7 and Prostate Cancer PC3 Cells by the Human Copper-Binding Peptide GHK-Cu, 2021; 5.

Copper tripeptide Preparation Products And Raw materials

Raw materials

Preparation Products

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Copper tripeptide Suppliers

China 174 India 1 United Kingdom 1 United States 8 USA 1 Global 185
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View Lastest Price from Copper tripeptide manufacturers

Wuhan Haorong Biotechnology Co.,Ltd
Product
Copper peptide 89030-95-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500
Release date
2023-08-02
hebei hongtan Biotechnology Co., Ltd
Product
?GHK-Cu 89030-95-5
Price
US $55.00-40.00/box
Min. Order
1box
Purity
99.99%
Supply Ability
1000
Release date
2024-03-14
hebei hongtan Biotechnology Co., Ltd
Product
GHK-Cu 89030-95-5
Price
US $55.00-40.00/BOX
Min. Order
1BOX
Purity
99%
Supply Ability
1000
Release date
2024-03-20

89030-95-5, Copper tripeptideRelated Search:

N-[1-Deoxy-3,4:5,6-bis-O-(1-methylethylidene)-D-glucitol-1-yl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine 2-propen-1-yl ester Prezatide copper acetate TFA-VAL-TYR-VAL-OH H-GLY-PRO-HYP-OH Palmitoyl Pentapeptide Palmitoyl Tripeptide-5 Acetyl Tetrapeptide-5 Palmitoyl Hexapeptide-12 Argireline Tripeptide-1 TYR-D-ALA-GLY-PHE-LEU (2S)-N2-(1-Oxohexadecyl)-L-lysyl-L-valyl-2,4-diaminobutanoic acid bis(trifluoroacetate) Acetyl Dipeptide-1 cetyl ester MET-GLU-HIS-PHE-ARG-TRP-GLY H-VAL-TRP-OH Rigin Biotinoyl tripeptide-1 Nonapeptide-1 Ghk Copper

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  • 89030-95-5
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