NSC319726

Product Name: NSC319726
CAS No.: 71555-25-4
Chemical Name: NSC319726
Synonyms: ZMC1;CS-981;NSC319726;NSC319726 USP/EP/BP;NSC 319726;NSC-319726;N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide;N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide;1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide;Azetidinecarbothioic acid, [1-(2-pyridinyl)ethylidene] hydrazide;(E)-N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide
CBNumber: CB52655418
Molecular Formula: C11H14N4S
Formula Weight: 234.32
MOL File: 71555-25-4.mol

More

Less

NSC319726 Property

Melting point:: 175-176 °C(Solv: acetonitrile (75-05-8))
Boiling point:: 367.7±34.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: insoluble in H2O; ≥3.43 mg/mL in EtOH with gentle warming and ultrasonic; ≥8.1 mg/mL in DMSO
form: solid
pka: 11.52±0.20(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23701
Product name: NSC 319726
Purity: ≥95%
Packaging: 5mg
Price: $97
Updated: 2024/03/01

Cayman Chemical

Product number: 23701
Product name: NSC 319726
Purity: ≥95%
Packaging: 10mg
Price: $175
Updated: 2024/03/01

Cayman Chemical

Product number: 23701
Product name: NSC 319726
Purity: ≥95%
Packaging: 25mg
Price: $385
Updated: 2024/03/01

Tocris

Product number: 5065
Product name: NSC319726
Purity: ≥98%(HPLC)
Packaging: 50
Price: $793
Updated: 2021/12/16

Tocris

Product number: 5065
Product name: NSC319726
Purity: ≥98%(HPLC)
Packaging: 10
Price: $195
Updated: 2021/12/16

More

Less

NSC319726 Chemical Properties,Usage,Production

Uses

NSC 319726 increases growth inhibitory activity in mutant p53 cells, particularly for the p53R175 mutant. NSC319726 is a p53R175 mutant reactivator and is a lead compound for p53-?targeted drug development.

Biological Activity

nsc 319726 is a reactivator of mutant p53 with ic50 value of 8nm [1].nsc 319726 belongs to the thiosemicarbazone family. in a mouse fibroblast cell line balb/c 3t3, nsc 319726 shows greater inhibition of cell growth in cells expressing mutant p53 than in wt p53 control. nsc 319726 is also nontoxic to wi38 human fibroblasts (p53 wt). in three different ovarian carcinoma cell lines (tov112d (p53r175h), ovcar3 (p53r248w) and skov3 (p53-/-)), treatment of nsc 319726 results in an induction of apoptosis in the p53r175 mutant. nsc 319726 restores p53 function through inducing a conformation change of mutant p53 to a “wt-like” structure which can be recognized by the wt specific antibody. the inhibition of cell growth caused by nsc 319726 is also found in the tov112d (p53r175h) xenografts when the dose of nsc 319726 is 1mg/kg. furthermore, it is shown that zinc ion chelation and ros changes are important for the apoptosis induced by nsc319726 [1].

References

[1] yu x, vazquez a, levine aj, carpizo dr. allele-specific p53 mutant reactivation. cancer cell. 2012 may 15;21(5):614-25.

NSC319726 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NSC319726 Suppliers

China 67 India 1 The Netherlands 1 United Kingdom 2 United States 15 Global 86

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

Aladdin Scientific

Tel: +1-+1(833)-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

71555-25-4, NSC319726Related Search:

NSC 756093 NSC23026 NSC59984 2-Pyridinecarbothioamide, N-2-pyridinyl- S3I-201 NSC745887 NSC 38280 Bortezomib Ceritinib Y27632 (hydrochloride) Stattic 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE ABT 737

CS-981

Azetidinecarbothioic acid, [1-(2-pyridinyl)ethylidene] hydrazide

1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide

NSC319726

1-Azetidinecarbothioic acid, 2-[1-(2-pyridinyl)ethylidene]hydrazide

1-Azetidinecarbothioic acid [1-(2-pyridinyl)ethylidene]hydrazide NSC319726

NSC 319726;NSC-319726

(E)-N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide

ZMC1

NSC319726 USP/EP/BP

N'-(1-(Pyridin-2-yl)ethylidene)azetidine-1-carbothiohydrazide

71555-25-4

Inhibitors