(-)-Pinoresinol 4-O-glucoside
- Product Name
- (-)-Pinoresinol 4-O-glucoside
- CAS No.
- 41607-20-9
- Chemical Name
- (-)-Pinoresinol 4-O-glucoside
- Synonyms
- (-)-Pinoresinol glucoside;(-)-pinoresinol glucoside;Pinoresinol beta-D-glucopyranoside;β-D-Glucopyranoside, (1R,3aS,4R,6aS)-2-methoxy-4-[tetrahydro-4-(4-hydroxy-3-methoxyphenyl)-1H,3H-furo[3,4-c]furan-1-yl]phenyl
- CBNumber
- CB52681141
- Molecular Formula
- C26H32O11
- Formula Weight
- 520.53
- MOL File
- 41607-20-9.mol
N-Bromosuccinimide Price
- Product number
- CD32001445
- Product name
- (-)-Pinoresinol4-O-glucoside
- Purity
- 95+%
- Packaging
- 5mg
- Price
- $730
- Updated
- 2021/12/16
(-)-Pinoresinol 4-O-glucoside Chemical Properties,Usage,Production
Uses
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active α-glucosidase inhibitor with an IC50 value of 48.13 μM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease[1][2].
Definition
ChEBI: (-)-Pinoresinol glucoside is a glycoside and a lignan.
in vivo
(-)-Pinoresinol 4-O-glucoside (50 mg/kg; p.o.; twenty days) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in mice[2].
| Animal Model: | 27-30 g, Male Swiss albino mice[2] |
| Dosage: | 50 mg/kg |
| Administration: | P.o.; twenty days |
| Result: | Exhibited a hepatoprotective activity in vivo as it lowered AST and ALT levels, caused a prominent decline in serum glucose level by 37.83% in streptozotocin-treated mice with promising elevation in insulin level of 25.37%. |
References
[1] Park KR, et al. Effects of PIN on Osteoblast Differentiation and Matrix Mineralization through Runt-Related Transcription Factor. Int J Mol Sci. 2020 Dec 16;21(24):9579. DOI:10.3390/ijms21249579
[2] Youssef FS, et al. Pinoresinol-4-O-β-D-glucopyranoside: a lignan from prunes (Prunus domestica) attenuates oxidative stress, hyperglycaemia and hepatic toxicity in vitro and in vivo. J Pharm Pharmacol. 2020 Dec;72(12):1830-1839. DOI:10.1111/jphp.13358
(-)-Pinoresinol 4-O-glucoside Preparation Products And Raw materials
Raw materials
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