MK-4827 (tosylate)

Product Name: MK-4827 (tosylate)
CAS No.: 1038915-73-9
Chemical Name: MK-4827 (tosylate)
Synonyms: Niraparib Tosylate;Niraparib TOS;Niraparib TsOH;MK-4827 (tosylate);Niraparib Tosilate;Niraparib(MK-4827) tosylate;MK-4827(Niraparib) tosylate;niraparib p-toluenesulfonate;MK-4827, Niraparib TsOH salt;Niraparib Tosylate (MK-4827)
CBNumber: CB52682012
Molecular Formula: C26H28N4O4S
Formula Weight: 492.58992
MOL File: 1038915-73-9.mol

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MK-4827 (tosylate) Property

Melting point:: >142oC (dec.)
storage temp.: -20°C Freezer
solubility: Methanol (Slightly)
form: Solid
color: Off-White to Pale Yellow
InChI: InChI=1/C19H20N4O.C7H8O3S/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14;1-6-2-4-7(5-3-6)11(8,9)10/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24);2-5H,1H3,(H,8,9,10)/t14-;/s3
InChIKey: LCPFHXWLJMNKNC-XOIICWPPNA-N
SMILES: S(C1C=CC(C)=CC=1)(O)(=O)=O.C(C1=CC=CC2=CN(C3C=CC([C@H]4CNCCC4)=CC=3)N=C12)(=O)N |&1:23,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 20842
Product name: MK-4827 (tosylate)
Purity: ≥98%
Packaging: 5mg
Price: $46
Updated: 2024/03/01

Cayman Chemical

Product number: 20842
Product name: MK-4827 (tosylate)
Purity: ≥98%
Packaging: 50 mg
Price: $253
Updated: 2024/03/01

Cayman Chemical

Product number: 20842
Product name: MK-4827 (tosylate)
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2023/01/06

Cayman Chemical

Product number: 20842
Product name: MK-4827 (tosylate)
Purity: ≥98%
Packaging: 10mg
Price: $83
Updated: 2024/03/01

Cayman Chemical

Product number: 20842
Product name: MK-4827 (tosylate)
Purity: ≥98%
Packaging: 25mg
Price: $149
Updated: 2024/03/01

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MK-4827 (tosylate) Chemical Properties,Usage,Production

Description

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively; with significant activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP, and Tank1. Niraparib tosylate leads to inhibition of repair of DNA damage, activates apoptosis, and shows anti-tumor activity.

Uses

Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

in vitro

In a whole-cell assay, Niraparib (MK-4827) tosylate hydrate inhibits PARP activity with EC50=4 nM and EC90=45 nM. Niraparib tosylate hydrate inhibits the proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC50 in the 10-100 nM range. Niraparib tosylate hydrate displays excellent PARP 1 and 2 inhibition with IC50=3.8 and 2.1 nM, respectively, and in a whole-cell assay. Niraparib tosylate hydrate inhibits PARP within 15 minutes of treatment, reaching about 85% inhibition in the A549 cells at 1 h and about 55% inhibition at 1 h for the H1299 cells.

MK-4827 (tosylate) Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-4827 (tosylate) Suppliers

China 121 India 3 United States 11 Global 135

BOC Sciences

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Musechem

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BOC Sciences

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Combi-Blocks Inc.

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View Lastest Price from MK-4827 (tosylate) manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: MK-4827 (tosylate) 1038915-73-9
Price: US $20.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-05-17

Zibo Hangyu Biotechnology Development Co., Ltd

Product: MK-4827 (tosylate) 1038915-73-9
Price: US $0.10-0.30/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20n tons
Release date: 2024-02-16

Henan Aochuang Chemical Co.,Ltd.

Product: Niraparib tosylate 2191-20-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-22

1038915-73-9, MK-4827 (tosylate)Related Search:

Nintedanib Triethyl orthoformate Tosyl azide EGF816 (mesylate) Ruxolitinib phosphate Epacadostat (INCB024360) Nintedanib Ethanesulfonate Salt MK-4827 (R-enantioMer) AnaMorelin hydrochloride BKM120 (NVP-BKM120, Buparlisib) tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate Niraparib Niraparib tosylate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide 3-(4-Bromophenyl)piperidine-1-carboxylic acid tert-butyl ester

Niraparib TsOH

niraparib p-toluenesulfonate

MK-4827(Niraparib) tosylate

Niraparib Tosylate

MK-4827 (tosylate)

(3S)-3-[4-[7-(Aminocarbonyl)-2H-indazol-2-yl]phenyl]piperidine tosylate

MK-4827, Niraparib TsOH salt

Niraparib(MK-4827) tosylate

NIRAPARIB TOSYLATE;MK 4827 TOSYLATE;MK4827 TOSYLATE

2H-Indazole-7-carboxamide,2-[4-[(3S)-3-piperidinyl]phenyl]-,4-methylbenzenesulfonate(1:1)

Niraparib TOS

MK-4827 (tosylate) ISO 9001：2015 REACH

Niraparib Tosylate (MK-4827)

(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate

Niraparib tosylate monohydrate (S)-2-(4-(piperidin-3-yl)phenyl)-2H-isoindole-4-carboxamide compound with 1-methyl-4-(methylsulfonyl)benzene (1:1) hydrate

Niraparib Tosilate

1038915-73-9

C19H20N4OC7H8O3S