ChemicalBook > CAS DataBase List > 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE

4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE

Product Name
4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE
CAS No.
150450-53-6
Chemical Name
4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE
Synonyms
MBCQ;v2330;N-(1,3-BENZODIOXOL-5-YLMETHYL)-6-CHLORO-4-QUINAZOLINAMINE;4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE;4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-;N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine;cGMP-PDE,inhibit,arteries,PGF2α,Inhibitor,MBCQ,Phosphodiesterase (PDE),coronary
CBNumber
CB5270640
Molecular Formula
C16H12ClN3O2
Formula Weight
313.74
MOL File
150450-53-6.mol
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4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Property

storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL (clear solution)
form 
powder
color 
white to beige
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0439
Product name
MBCQ
Purity
≥98% (HPLC)
Packaging
5mg
Price
$90.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0439
Product name
MBCQ
Purity
≥98% (HPLC)
Packaging
25mg
Price
$392
Updated
2022/05/15
Cayman Chemical
Product number
21017
Product name
MBCQ
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21017
Product name
MBCQ
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
21017
Product name
MBCQ
Packaging
10mg
Price
$153
Updated
2024/03/01
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4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Chemical Properties,Usage,Production

Uses

MBCQ is a selective inhibitor of cGMP-specific phosphodiesterase.

Definition

ChEBI: N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-4-quinazolinamine is a member of quinazolines.

Biological Activity

mbcq is a cgmp-specific phosphodiesterase pde5 inhibitor.the phosphodiesterase type 5 inhibitor (pde5 inhibitor) is an agent used to inhibit the degradative action of cgmp-specific pde5 on cyclic gmp in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. pde5 drugs are used in the treatment of erectile dysfunction and were the first effective oral treatment for this condition. sinve pde5 is also present in the arterial wall smooth muscle within the lungs, pde5 inhibitors have also been applied for the pulmonary hypertension treatment.

in vitro

in previous study, it was found that the addition of mbcq to the blood vessle samples could lead to an 80 to 85% inhibition of pde activity, indicating that most of the activity present in these blood vessels could be attributed to pde5. [1].

in vivo

in animal rat study, tolerance was induced by continuous exposure to glyceryl trinitrate (gtn) for 48 h. results showed that mbcq could significantly decrease the ec(50) values for gtn-induced relaxation in both tolerant and nontolerant tissues, but with the greatest relative shift showing in tolerant veins. moreover, mbcq could also increase the vasodilator potency of a nitric oxide donor (1,1-diethyl-2-hydroxy-2-nitrosohydrazine). a significant increase in cgmp pde activity was found in tolerant femoral vein, whereas pde activity was unchanged in femoral artery [1].

References

[1] macpherson jd, gillespie td, dunkerley ha, maurice dh, bennett bm. inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation. j pharmacol exp ther. 2006 apr;317(1):188-95.

4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE Suppliers

150450-53-6, 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINERelated Search:


  • MBCQ
  • 4-[[3,4-(METHYLENEDIOXY)BENZYL]AMINO]-6-CHLOROQUINAZOLINE
  • N-(1,3-BENZODIOXOL-5-YLMETHYL)-6-CHLORO-4-QUINAZOLINAMINE
  • 4-Quinazolinamine, N-(1,3-benzodioxol-5-ylmethyl)-6-chloro-
  • v2330
  • cGMP-PDE,inhibit,arteries,PGF2α,Inhibitor,MBCQ,Phosphodiesterase (PDE),coronary
  • N-(Benzo[d][1,3]dioxol-5-ylmethyl)-6-chloroquinazolin-4-amine
  • 150450-53-6