Nexturastat A
- Product Name
- Nexturastat A
- CAS No.
- 1403783-31-2
- Chemical Name
- Nexturastat A
- Synonyms
- CS-1289;Nexturastat A;Nextunastat A;Nexturastat A, >97%;Nexturastat A, >=98%;Nexturastat A (AG-CR1-3901);4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE;4-[[butyl(phenylcarbamoyl)amino]methyl]-N-hydroxybenzamide;4-[[Butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxybenzamide;Benzamide, 4-[[butyl[(phenylamino)carbonyl]amino]methyl]-N-hydroxy-
- CBNumber
- CB52715657
- Molecular Formula
- C19H23N3O3
- Formula Weight
- 341.4
- MOL File
- 1403783-31-2.mol
Nexturastat A Property
- Density
- 1.228±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; ≥16.3 mg/mL in DMSO; ≥9.3 mg/mL in EtOH
- form
- solid
- pka
- 8.95±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 16874
- Product name
- Nexturastat A
- Purity
- ≥95%
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16874
- Product name
- Nexturastat A
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16874
- Product name
- Nexturastat A
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $477
- Updated
- 2024/03/01
- Product number
- 16874
- Product name
- Nexturastat A
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $834
- Updated
- 2024/03/01
- Product number
- N391500
- Product name
- NexturastatA
- Packaging
- 25mg
- Price
- $1760
- Updated
- 2021/12/16
Nexturastat A Chemical Properties,Usage,Production
Uses
Nexturastat A is a potent and selective histone deacetylase 6 (HDAC6) inhibitor that shows potential antiproliferative effects against melanoma cells.
Biological Activity
nexturastat a is a selective inhibitor of histone deacetylase 6 (hdac6) with ic50 value of 5.2 nm [1].nexturastat a is a hdac inhibitor. it was developed by structural modification of aryl urea hdacis. the inhibitory activity of nexturastat a is most potent against hdac6 with ic50 value of 5.2 nm. besides that, nexturastat a also shows inhibition of other hdacs with ic50 values of 3.02, 6.92, 6.68, 9.39, 11.7, 4.46, 0.954, 6.72, 7.57 and 5.14 μm for hdac1, 2, 3, 4, 5, 7, 8, 9, 10 and 11, respectively. nexturastat a has been shown to suppress cell proliferation and promote apoptosis in b16 murine melanoma cells [1, 2].
target
HDAC6
References
[1] kalin j h, bergman j a. development and therapeutic implications of selective histone deacetylase 6 inhibitors. journal of medicinal chemistry, 2013, 56(16): 6297-6313.
[2] zhang l, han y, jiang q, et al. trend of histone deacetylase inhibitors in cancer therapy: isoform selectivity or multitargeted strategy. medicinal research reviews, 2014.
Nexturastat A Preparation Products And Raw materials
Raw materials
Preparation Products
Nexturastat A Suppliers
View Lastest Price from Nexturastat A manufacturers
- Product
- 4-((1-BUTYL-3-PHENYLUREIDO)METHYL)-N-HYDROXYBENZAMIDE 1403783-31-2
- Price
- US $1.00/ASSAYS
- Min. Order
- 1ASSAYS
- Purity
- 98%
- Supply Ability
- 10kg
- Release date
- 2019-09-04