ChemicalBook > CAS DataBase List > UNC2881

UNC2881

Product Name: UNC2881
CAS No.: 1493764-08-1
Chemical Name: UNC2881
Synonyms: 110849;UNC2881;CS-1177;UNC2881 ，S7325;UNC2881 USP/EP/BP;UNC 2881; UNC-2881;UNC2881, 10 mM in DMSO;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine;N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide;N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide
CBNumber: CB52715677
Molecular Formula: C25H33N7O2
Formula Weight: 463.58
MOL File: 1493764-08-1.mol

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UNC2881 Property

Density: 1.31±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥13.55 mg/mL in DMSO
form: solid
pka: 12.70±0.46(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 29012
Product name: UNC2881
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 29012
Product name: UNC2881
Packaging: 50mg
Price: $775
Updated: 2024/03/01

Cayman Chemical

Product number: 29012
Product name: UNC2881
Packaging: 10mg
Price: $187
Updated: 2024/03/01

Cayman Chemical

Product number: 29012
Product name: UNC2881
Packaging: 25mg
Price: $414
Updated: 2024/03/01

Tocris

Product number: 6537
Product name: UNC2881
Purity: ≥98%(HPLC)
Packaging: 5
Price: $89
Updated: 2021/12/16

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UNC2881 Chemical Properties,Usage,Production

Description

UNC2881 is an inhibitor of Mer (IC₅₀ = 4.3 nM), a member of the TAM family of receptor tyrosine kinases. It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC₅₀s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC₅₀ = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.

Uses

UNC2881 is a specific Mer tyrosine kinase inhibitor. It inhibits collagen-stimulated platelet aggregation.

in vivo

UNC2881 (3 mg/kg; p.o.; single dose) has high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability, displays terminal half-life of 0.80 h^[1].
UNC2881 (3 mg/kg; i.v.; injected with VSV on days -3, -2, -1, and 0) limits Mertk signaling, and promotes the antiviral immune response, reducing the viral replication of vesicular stomatitis virus (VSV) in infected mice^[2].
Pharmacokinetics of UNC2881 in mice^[1]

Route	Dose (mg/kg)	T_1/2 (h)	T_max (h)	C_max (ng/mL)	AUC_last (ng·h/mL)	CL_obs (mL/min)	V_ss (L/kg)	F (%)
IV	3	0.8		2609	527	94.5	1.65
PO	3		0.30	90.0	71.7			14

Animal Model:	C57BL/6 mice (7-10 weeks old)^[2]
Dosage:	3 mg/kg
Administration:	Intravenous injection; infected with 2×10⁸ PFU vesicular stomatitis virus (VSV) (i.v.) on days -3, -2, -1, and 0
Result:	Reduced VSV replication in spleen, liver, kidney, lung.

target

Mer tyrosine kinase

IC 50

Axl; Mer

storage

Store at +4°C

References

[1]. zhang w, mciver al, stashko ma, et al. discovery of mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. j med chem, 2013, 56(23): 9693-9700.

UNC2881 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC2881 Suppliers

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1493764-08-1, UNC2881Related Search:

UNC2541 UNC 1999 UNC0379 UNC 1025 UNC2250 GSK2656157 GSK 2334470 2-Pyridinamine, 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]- Afatinib AZD-9291 UNC 669 UNC0321 UNC-1215 UNC-926 Hydochloride UNC3230 UNC0646 UNC2025 UNC 1079

2-(Butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide

UNC2881

N-(4-(1H-iMidazol-1-yl)benzyl)-2-(butylaMino)-4-(((1r,4r)-4-hydroxycyclohexyl)aMino)pyriMidine-5-carboxaMide

N-(4-(1H-imidazol-1-yl)benzyl)-2-(butylamino)-4-((1r,4r)-4-hydroxycyclohexylamino)pyrimidine-5-carboxamide UNC2881

N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-(((1r,4r)-4-hydroxycyclohexyl)amino)pyrimidine

110849

UNC 2881; UNC-2881

CS-1177

5-Pyrimidinecarboxamide, 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-

UNC2881 USP/EP/BP

N-(4-(1H-Imidazol-1-yl)benzyl)-2-(butylamino)-4-((trans-4-hydroxycyclohexyl)amino)pyrimidine-5-carboxamide

UNC 2881,Mer,phosphorylation,inhibit,UNC-2881,orally active,UNC2881,Tyro3,pathologic thrombosis,Axl,Inhibitor,platelet aggregation,TAM Receptor

UNC2881, 10 mM in DMSO

UNC2881 ，S7325

1493764-08-1

Inhibitors