ChemicalBook > CAS DataBase List > OTSSP167HCL

OTSSP167HCL

Product Name
OTSSP167HCL
CAS No.
1431698-10-0
Chemical Name
OTSSP167HCL
Synonyms
OTS167 HCl;OTSSP167HCL;OTSSP167 HCl (OTS167);OTS-167 hydrochloride;OTSSP167 HCl (OTS167 HCl);MELK INHIBITOR; OTSSP-167; OTSSP 167;OTSSP167hydrochloride/OTSSP-167hydrochloride;1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone hydrochloride;Ethanone,1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-,hydrochloride(1:1);OTSSP-167,OTSSP 167,OTSSP167,OTSSP167 hydrochloride,MELK,OTSSP-167 hydrochloride,Maternal embryonic leucine zipper kinase,inhibit,OTS167,OTS-167,OTS 167,Inhibitor
CBNumber
CB52718395
Molecular Formula
C25H29Cl3N4O2
Formula Weight
523.88236
MOL File
1431698-10-0.mol
More
Less

OTSSP167HCL Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
crystalline solid
color 
Light yellow to gray
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
16873
Product name
OTSSP167 (hydrochloride)
Purity
≥95%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
16873
Product name
OTSSP167 (hydrochloride)
Purity
≥95%
Packaging
5mg
Price
$270
Updated
2024/03/01
Cayman Chemical
Product number
16873
Product name
OTSSP167 (hydrochloride)
Purity
≥95%
Packaging
10mg
Price
$477
Updated
2024/03/01
ChemScene
Product number
CS-1241
Product name
OTSSP167(hydrochloride)
Purity
99.84%
Packaging
5mg
Price
$180
Updated
2021/12/16
ApexBio Technology
Product number
B1308
Product name
OTSSP167hydrochloride
Packaging
2mg
Price
$215
Updated
2021/12/16
More
Less

OTSSP167HCL Chemical Properties,Usage,Production

Biological Activity

otssp167 is an inhibitor of maternal embryonic leucine zipper kinase(melk) with ic50 value of 0.41nm [1].melk belongs to the ampk serine/threonine kinase family and involves in the mammalian embryonic development. it overexpresses in various types of human cancer. otssp167 is synthetized from a compound which is a hit of a high-throughput screening. in vitro anti-proliferative assay shows that otssp167 suppresses cell growth of various cancer cell lines, such as a549(ic50=6.7nm), t47d(ic50=4.3nm), du4475(ic50=2.3nm) and 22rv1(ic50= 6.0nm). in vivo assay also shows otssp167 can significantly suppress tumor growth in the xenograft model using various cancer cell lines. the effects are observed by both intravenous administration and oral administration. when investigating the substrates of melk, otssp167 is found to inhibit the phosphorylation of dbnl and psma1 in vitro. since psma1 is essential for survival of cancer cells, the reduction of phosphorylated psma1 caused by otssp167 can subsequently suppress mammosphere formation of cancer stem cells [1].

in vitro

OTSSP167 inhibits the growth of A549 (lung), T47D (breast), DU4475 (breast), 22Rv1 (prostate) and HT1197 (bladder) cancer cells with IC 50 values of 6.7 , 4.3, 2.3, 6.0 and 97 nM, respectively. It can abrogate the mitotic checkpoint, disrupt MCC and MCC-APC/C interaction in MCF7 cells, and causes GFP-MELK localization to cell cortex in prometaphase cells. OTSSP167 is a MELK selective inhibitor, exhibits a strong in vitro activity, conferring an IC 50 of 0.41 nM.

in vivo

OTSSP167 (20 mg/kg, iv) results in tumor growth inhibition (TGI) of 73% in xenograft mouse model; OTSSP167 (1, 5, and 10 mg/kg, po) reveals TGI of 51, 91, and 108%, respectively. OTSSP167 (20 mg/kg, po) shows no tumor growth suppressive effect on PC-14 xenografts.

target

IC50: 0.41 nM (MELK)

References

[1] suyoun chung, hanae suzuki, takashi miyamoto et al. development of an orally-administrative melk-targeting inhibitor that suppresses the growth of various types of human cancer. oncotarget. 2012, 3: 1629-1640.

OTSSP167HCL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

OTSSP167HCL Suppliers

China 50 United States 9 Global 59
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58

1431698-10-0, OTSSP167HCLRelated Search:

Pyridine hydrochloride SULFAPHENAZOLE Aniline hydrochloride Trimethylamine hydrochloride Betaine hydrochloride Methylamine hydrochloride Dimethylamine hydrochloride

  • OTSSP167HCL
  • OTSSP167hydrochloride/OTSSP-167hydrochloride
  • OTSSP167 HCl (OTS167 HCl)
  • 1-[6-(3,5-Dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-ethanone hydrochloride
  • MELK INHIBITOR; OTSSP-167; OTSSP 167
  • OTS-167 hydrochloride
  • Ethanone,1-[6-(3,5-dichloro-4-hydroxyphenyl)-4-[[trans-4-[(dimethylamino)methyl]cyclohexyl]amino]-1,5-naphthyridin-3-yl]-,hydrochloride(1:1)
  • OTSSP167 HCl (OTS167)
  • OTSSP-167,OTSSP 167,OTSSP167,OTSSP167 hydrochloride,MELK,OTSSP-167 hydrochloride,Maternal embryonic leucine zipper kinase,inhibit,OTS167,OTS-167,OTS 167,Inhibitor
  • OTS167 HCl
  • 1431698-10-0
  • C25H28Cl2N4O2HCl
  • C25H29Cl3N4O2