4-Bromo-2-nitrophenol
- Product Name
- 4-Bromo-2-nitrophenol
- CAS No.
- 7693-52-9
- Chemical Name
- 4-Bromo-2-nitrophenol
- Synonyms
- nsc402972;4-Bromo-nitrophenol;4-Bromo-2-nitrophel;4-BROMO-2-NITROPHENOL;4-bromo-2-nitro-pheno;2-NITRO-4-BROMOPHENOL;PHENOL, 2-NITRO-5-BROMO-;Phenol, 4-bromo-2-nitro-;4-Bromo-2-nitrophenol,98%;4-Bromo-2-nitrophenol >
- CBNumber
- CB5273414
- Molecular Formula
- C6H4BrNO3
- Formula Weight
- 218
- MOL File
- 7693-52-9.mol
4-Bromo-2-nitrophenol Property
- Melting point:
- 90-94 °C (lit.)
- Boiling point:
- 259.4±20.0 °C(Predicted)
- Density
- 1.8994 (rough estimate)
- refractive index
- 1.6090 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 6.28±0.14(Predicted)
- form
- Crystalline Powder or Crystals
- color
- Yellow
- Water Solubility
- Slightly soluble
- InChI
- InChI=1S/C6H4BrNO3/c7-4-1-2-6(9)5(3-4)8(10)11/h1-3,9H
- InChIKey
- CUTFAPGINUFNQM-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(Br)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 7693-52-9(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38-20/22
- Safety Statements
- 26-36-36/37/39
- WGK Germany
- 3
- RTECS
- SJ8370000
- Hazard Note
- Harmful
- HS Code
- 29089990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 309877
- Product name
- 4-Bromo-2-nitrophenol
- Purity
- 98%
- Packaging
- 5g
- Price
- $42.9
- Updated
- 2024/03/01
- Product number
- 309877
- Product name
- 4-Bromo-2-nitrophenol
- Purity
- 98%
- Packaging
- 25g
- Price
- $137
- Updated
- 2023/06/20
- Product number
- B2363
- Product name
- 4-Bromo-2-nitrophenol
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $35
- Updated
- 2024/03/01
- Product number
- B2363
- Product name
- 4-Bromo-2-nitrophenol
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $138
- Updated
- 2024/03/01
- Product number
- H26529
- Product name
- 4-Bromo-2-nitrophenol, 98%
- Packaging
- 5g
- Price
- $47.65
- Updated
- 2024/03/01
4-Bromo-2-nitrophenol Chemical Properties,Usage,Production
Description
4-bromo-2-nitrophenol is an essential intermediate for fine chemical engineering. It can be used to synthesize derivatives with biological activity, such as heterocyclic compounds as peptidase inhibitors for treating diabetes, introducing fluorine-containing groups as pesticides, and aminic compounds as Btk inhibitors for treating immune diseases.
Chemical Properties
yellow crystalline powder or crystals
Synthesis Reference(s)
The Journal of Organic Chemistry, 32, p. 300, 1967 DOI: 10.1021/jo01288a012
Synthesis, p. 287, 1989
General Description
The Suzuki coupling of 4-bromo-2-nitrophenol with boronic acid was studied.
Synthesis
The synthesis method of 4-bromo-2-nitrophenol comprises the following steps: preparing nitric acid with a concentration of 7-8 M; dissolving p-bromophenol in dichloroethane to obtain a substrate with a concentration of 1.8-2.2 M; injecting the nitric acid and the substrate into a continuous flow reactor through two pumps respectively, mixing, controlling the temperature at 55-75°C, the reaction pressure at 0.35-0.45 MPa, and reacting for 20-30 min.
4-Bromo-2-nitrophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2-nitrophenol manufacturers
- Product
- 4-Bromo-2-nitrophenol 7693-52-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 5 tons
- Release date
- 2024-10-23
- Product
- 4-Bromo-2-nitrophenol 7693-52-9
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 2-Nitro-4-bromophenol 7693-52-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2 tons
- Release date
- 2022-12-06