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NBQX DISODIUM SALT

Product Name
NBQX DISODIUM SALT
CAS No.
118876-58-7
Chemical Name
NBQX DISODIUM SALT
Synonyms
NBQX;FG 9202;NBQX NEW;NBQX HYDRATE;NBQX DISODIUM;FG 9202 DISODIUM;Dihydroxyquinone;NBQX DISODIUM SALT;FG9202;FG-9202;FG 9202;NBQX disodium salt hydrate
CBNumber
CB5274224
Molecular Formula
C12H8N4O6S
Formula Weight
336.28
MOL File
118876-58-7.mol
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NBQX DISODIUM SALT Property

Melting point:
361°C
Density 
1.6027 (rough estimate)
refractive index 
1.6000 (estimate)
storage temp. 
Inert atmosphere,2-8°C
solubility 
methanol: 0.25 mg/mL
form 
solid
pka
7.55±0.20(Predicted)
color 
yellow
Stability:
Freezer at -20°C
InChIKey
UQNAFPHGVPVTAL-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
N171
Product name
NBQX hydrate
Purity
powder, ≥98% (HPLC)
Packaging
5mg
Price
$270
Updated
2024/03/01
Sigma-Aldrich
Product number
N171
Product name
NBQX hydrate
Purity
powder, ≥98% (HPLC)
Packaging
25mg
Price
$444
Updated
2024/03/01
Sigma-Aldrich
Product number
N183
Product name
NBQX disodium salt hydrate
Purity
≥98% (HPLC), lyophilized solid
Packaging
5mg
Price
$320
Updated
2024/03/01
Sigma-Aldrich
Product number
N183
Product name
NBQX disodium salt hydrate
Purity
≥98% (HPLC), lyophilized solid
Packaging
25mg
Price
$1290
Updated
2024/03/01
Tocris
Product number
0373
Product name
NBQX
Purity
≥98%(HPLC)
Packaging
50
Price
$910
Updated
2021/12/16
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NBQX DISODIUM SALT Chemical Properties,Usage,Production

Chemical Properties

Yellow Crystalline Solid

Uses

A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.

Uses

NBQX disodium salt hydrate has been used:

  • in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
  • as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
  • in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)

Definition

ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.

General Description

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ .

Biochem/physiol Actions

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.

storage

Room temperature

NBQX DISODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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NBQX DISODIUM SALT Suppliers

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118876-58-7, NBQX DISODIUM SALTRelated Search:

DNQX CNQX (RS)-AMPA 1-(4'-AMINOPHENYL)-3,5-DIHYDRO-7,8-DIMETHOXY-4H-2,3-BENZODIAZEPIN-4-ONE 1,8-Dihydroxyanthraquinone NBQX DISODIUM SALT 6-NITROQUINOXALINE-2,3-DIONE 4-Nitro-1-naphthylamine 6-NITRO-1,2,3,4-TETRAHYDRO QUINOXALINE 7-NITRO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE N'-METHYL-4-NITROPHENYLENEDIAMINE-(1,2) 1,2,3,4-Tetrahydro-quinoxalin-6-ylamine 2,3-Quinoxalinedione,6-amino-1,4-dihydro-(9CI) NBQX DISODIUM SALT N-ACETYL-4-NITRO-1-NAPHTHYLAMINE [10-3H]NBQX ACETAMIDE, N-(4-AMINO-1-NAPHTHYL)- 2,3-QUINOXALINEDIONE, 1,4-DIHYDRO-6-NITRO-, MONOHYDRATE

  • NBQX
  • 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline
  • FG 9202, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate
  • FG 9202 hydrate disodium salt, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate disodium salt
  • NBQX hydrate disodium salt
  • 2,3-Doxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
  • FG 9202 disodium salt hydrate
  • 2,3-Dihydroxy-6-nitrobenzo[f]quinoxaline-7-sulfonamide
  • 6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3(1H,4H)-dione
  • 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate
  • NBQX disodium salt hydrate
  • 6-Nitro-2,3-dioxo-2,3-dihydrobenzo[f]quinoxaline-7-sulfonamide
  • NBQX DISODIUM
  • NBQX DISODIUM SALT
  • 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate
  • disodium 6-nitro-7-sulfamoylbenzo[f]quinoxaline-2,3-diolate hydrate
  • FG9202;FG-9202;FG 9202
  • 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline
  • 6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE
  • 6-NITRO-7-SULFAMOYLBENZO[F]QUINOXALINE-2,3-DIONE, DISODIUM SALT
  • 6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE
  • 6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE-2,3-DIONE 2NA
  • 1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE
  • 1,2,3,4-TETRAHYDRO-6-NITRO-2,3-DIOXO-BENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM
  • 2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE
  • 2,3-DIHYDROXY-6-NITRO-7-SULPHAMOYLBENZO(F)-QUINOXALINE 2NA
  • 2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE
  • 2,3-DIOXO-6-NITRO-1,2,3,4-TETRAHYDROBENZO[F]QUINOXALINE-7-SULFONAMIDE DISODIUM SALT
  • FG 9202
  • FG 9202 DISODIUM
  • NBQX DISODIUM (FG 9202) NEUROPROTECTIVE GLUTA
  • NBQX HYDRATE
  • 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt
  • NBQX NEW
  • Benzo[f]quinoxaline-7-sulfonamide, 1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-
  • 6-Nitro-2,3-dioxo-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide
  • Dihydroxyquinone
  • NBQX disodium salt (mM/ml), AMPA / kainate antagonist
  • NBQX, AMPA / kainate antagonist
  • 118876-58-7
  • C12H6N4Na2O6S
  • C12H8N4O6S
  • C12H6N4O6SNa2
  • Ligand-Gated Ion Channels
  • Ionotropic Glutamate Receptor Modulators
  • Ion Channels
  • Cell Biology
  • Cell Signaling and Neuroscience
  • BioChemical
  • Glutamate
  • Glutamate receptor
  • Heterocyclic Compounds
  • Neurochemicals