ChemicalBook > CAS DataBase List > Csn-B

Csn-B

Product Name: Csn-B
CAS No.: 321661-62-5
Chemical Name: Csn-B
Synonyms: Cytosporone B;Csn-B;Dothiorelone G;Cytosporone B, 10 mM in DMSO;ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate;Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate;(3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester;Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester
CBNumber: CB52750977
Molecular Formula: C18H26O5
Formula Weight: 322.4
MOL File: 321661-62-5.mol

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Csn-B Property

Boiling point:: 471.6±24.0 °C(Predicted)
Density: 1.126±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >20mg/mL
pka: 7.54±0.40(Predicted)
form: A crystalline solid
color: white to off-white
InChI: InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
InChIKey: UVVWQQKSNZLUQA-UHFFFAOYSA-N
SMILES: C1(CC(OCC)=O)=CC(O)=CC(O)=C1C(=O)CCCCCCC

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C2997
Product name: Cytosporone B
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $163.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: C2997
Product name: Cytosporone B
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $641.25
Updated: 2025/07/31

Cayman Chemical

Product number: 17501
Product name: Cytosporone B
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 17501
Product name: Cytosporone B
Purity: ≥95%
Packaging: 5mg
Price: $131
Updated: 2024/03/01

Cayman Chemical

Product number: 17501
Product name: Cytosporone B
Purity: ≥95%
Packaging: 10mg
Price: $243
Updated: 2024/03/01

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Csn-B Chemical Properties,Usage,Production

Uses

Cytosporone B is a naturally occuring agonist for the nuclear receptor Nur77., induces the expression of Nur77-dependent genes including the gene for Nur77 itself. Induces apoptosis in cancer cells.

Uses

Cytosporone B has been used:

as a positive control and NR4A1 agonist in NR4A1 reporter gene assay
for Nr4a1 activation
to treat OVX mice and study its effect on migration of osteoclast precursor

Definition

ChEBI: 2-[3,5-dihydroxy-2-(1-oxooctyl)phenyl]acetic acid ethyl ester is an aromatic ketone.

Biochem/physiol Actions

Cytosporone B (Csn-B) is the first naturally occurring agonist for nuclear orphan receptor Nur77. It binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is a nuclear receptor/transcription factor. A physiological ligand for Nur77 is as yet unknown, but there is increasing interest in Nur77 because of its known activities. Translocation of Nur77 from the nucleus to mitochondria initiates cell apoptosis, making it a potential target for cancer treatment. Nur77 is also involved in glucose homeostasis; it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.

in vivo

In the hepatocytes of wild-type mice, the transcriptional activity of the reporter is induced five-fold with cytosporone B treatment. In wild-type mice, cytosporone B treatment significantly increases glucose levels from 3.2 to 11.4 mM within the first 30 min, and thereafter blood glucose gradually decreased before reaching the initial level after 300 min^[1].

IC 50

Nur77/NR4A1

storage

Store at -20°C

Csn-B Preparation Products And Raw materials

Raw materials

Preparation Products

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Csn-B Suppliers

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321661-62-5, Csn-BRelated Search:

beta-Eudesmol Hydroxyecdysone 2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one hydroxygenkwanin MOSLOFLAVONE alpha-Cyperone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one beta-Sitosterol alpha-Terpineol Artemether

3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester

3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester

Csn-B

Cytosporone B

ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate

Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester

N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBE<WBR />NZAMIDE

Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate

Dothiorelone G

(3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester

Cytosporone B, 10 mM in DMSO

321661-62-5