ChemicalBook > CAS DataBase List > Csn-B

Csn-B

Product Name
Csn-B
CAS No.
321661-62-5
Chemical Name
Csn-B
Synonyms
Cytosporone B;Csn-B;Dothiorelone G;ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate;Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate;(3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester;Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester;N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBENZAMIDE
CBNumber
CB52750977
Molecular Formula
C18H26O5
Formula Weight
322.4
MOL File
321661-62-5.mol
More
Less

Csn-B Property

Boiling point:
471.6±24.0 °C(Predicted)
Density 
1.126±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: >20mg/mL
pka
7.54±0.40(Predicted)
form 
A crystalline solid
color 
white to off-white
InChI
InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
InChIKey
UVVWQQKSNZLUQA-UHFFFAOYSA-N
SMILES
C1(CC(OCC)=O)=CC(O)=CC(O)=C1C(=O)CCCCCCC
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C2997
Product name
Cytosporone B
Purity
≥98% (HPLC)
Packaging
5mg
Price
$167
Updated
2024/03/01
Sigma-Aldrich
Product number
C2997
Product name
Cytosporone B
Purity
≥98% (HPLC)
Packaging
25mg
Price
$657
Updated
2024/03/01
Cayman Chemical
Product number
17501
Product name
Cytosporone B
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17501
Product name
Cytosporone B
Purity
≥95%
Packaging
5mg
Price
$131
Updated
2024/03/01
Cayman Chemical
Product number
17501
Product name
Cytosporone B
Purity
≥95%
Packaging
10mg
Price
$243
Updated
2024/03/01
More
Less

Csn-B Chemical Properties,Usage,Production

Uses

Cytosporone B is a naturally occuring agonist for the nuclear receptor Nur77., induces the expression of Nur77-dependent genes including the gene for Nur77 itself. Induces apoptosis in cancer cells.

Uses

Cytosporone B has been used:

  • as a positive control and NR4A1 agonist in NR4A1 reporter gene assay
  • for Nr4a1 activation
  • to treat OVX mice and study its effect on migration of osteoclast precursor

Definition

ChEBI: 2-[3,5-dihydroxy-2-(1-oxooctyl)phenyl]acetic acid ethyl ester is an aromatic ketone.

Biochem/physiol Actions

Cytosporone B (Csn-B) is the first naturally occurring agonist for nuclear orphan receptor Nur77. It binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is a nuclear receptor/transcription factor. A physiological ligand for Nur77 is as yet unknown, but there is increasing interest in Nur77 because of its known activities. Translocation of Nur77 from the nucleus to mitochondria initiates cell apoptosis, making it a potential target for cancer treatment. Nur77 is also involved in glucose homeostasis; it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.

storage

Store at -20°C

Csn-B Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Csn-B Suppliers

A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58

321661-62-5, Csn-BRelated Search:


  • 3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester
  • 3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
  • Csn-B
  • Cytosporone B
  • ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate
  • Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester
  • N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBE<WBR />NZAMIDE
  • Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
  • Dothiorelone G
  • (3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester
  • 321661-62-5