Pyrazofurin

Product Name: Pyrazofurin
CAS No.: 30868-30-5
Chemical Name: Pyrazofurin
Synonyms: PRZF;47599;A-23813;nsc143095;pyrazofurin;pirazofurin;Pyrazomycin;Pyrozofurin;compound47599;β-Pyrazofurin
CBNumber: CB5276253
Molecular Formula: C9H13N3O6
Formula Weight: 259.22
MOL File: 30868-30-5.mol

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Pyrazofurin Property

Boiling point:: 584.4±50.0 °C(Predicted)
Density: 1.785±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO, Water (Slightly)
form: powder
pka: 7.17±0.50(Predicted)
color: white to light brown
optical activity: [α]/D -49 to -39°, c = 0.5 in H2O
Water Solubility: H2O: 5mg/mL, clear (warmed)
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1502
Product name: Pyrazofurin
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $154
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML1502
Product name: Pyrazofurin
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $585.2
Updated: 2025/07/31

American Custom Chemicals Corporation

Product number: API0008977
Product name: PYRAZOFURIN
Purity: 95.00%
Packaging: 10MG
Price: $666.75
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008977
Product name: PYRAZOFURIN
Purity: 95.00%
Packaging: 100MG
Price: $3433.5
Updated: 2021/12/16

ChemScene

Product number: CS-0085864
Product name: Pyrazofurin
Purity: ≥98.0%
Packaging: 5mg
Price: $400
Updated: 2021/12/16

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Pyrazofurin Chemical Properties,Usage,Production

Uses

Geldanamycin (G304500) derivative.

Definition

ChEBI: A C-glycosyl compound that is 4-hydroxy-1H-pyrazole-5-carboxamide in which the hydrogen at position 3 has been replaced by a beta-D-ribofuranosyl group.

Biochem/physiol Actions

Pyrazofurin serves as an effective drug against HIV (human immuno virus), vaccinia virus, West Nile viral infection.

Enzyme inhibitor

This pyrimidine nucleoside (FW = 261.23 g/mol), also known as pyrazomycin, exhibits antineoplastic activity and inhibits cell proliferation and DNA synthesis in cells by inhibiting orotidylate decarboxylase (uridine 5'-phosphate synthase). Pyrazofurin, also known as 3,b-D-ribofuranosyl-4- hydroxypyrazole-5-carboxamide, is the prodrug of the 5’-phosphate derivative. Target(s): adenosylhomocysteinase; 5-aminoimidazole-4- carboxamide-1-b-D-ribofuranosyl 5'-monophosphate formyltransferase; orotate phosphoribosyltransferase; orotidylate decarboxylase, or UMP synthase.

in vivo

Pyrazofurin (0.25-5 mg/kg; subcutaneous injection; 5 days) has an ameliorative effect in mice infected with Rift Valley fever virus^[4].

Animal Model:	Rift Valley fever virus-infected female Swiss Webster mice aged 3-4 weeks old^[4]
Dosage:	0.25, 2.5 and 10 mg/kg
Administration:	Subcutaneous injection (s.c.); 5 days
Result:	Increased survival rate and generally prolonged life at 0.25 mg/kg dose. Was uniformly ineffective at protecting mice from death but did increase the time to death at 2.5 mg/kg dose. Had toxic to mice at high doses (10 mg/kg).

Pyrazofurin Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrazofurin Suppliers

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View Lastest Price from Pyrazofurin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Pyrazofurin 30868-30-5
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-07-22

30868-30-5, PyrazofurinRelated Search:

Pyrazole-3-carboxamide 1-(5-methyl-1H-pyrazol-3-yl)methanamine 5'-deoxypyrazofurin 4-hydroxypyrazole 5-METHYL-1H-PYRAZOLE-3-CARBOXAMIDE 5-methyl-1H-pyrazole-3-carbaldehyde 3-(Aminomethyl)pyrazole 3-ETHYL-1H-PYRAZOLE-5-CARBALDEHYDE (1H-PYRAZOL-3-YL)METHANOL 4-AMINO-1-METHYL-3-PROPYLPYRAZOLE-5-CARBOXAMIDE HYDROCHLORIDE 2H-PYRAZOLE-3-CARBALDEHYDE Pyrazofurin 3,5-Dimethylpyrazole 2,2'-Oxydipropanol

3-beta-d-ribofuranosyl-4-hydroxypyrazole-5-carboxamide

4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamid

4-hydroxy-3-beta-d-ribofuranosyl-1h-pyrazole-5-carboxamide

antibiotica23813

beta-pyrazomycin

compound47599

nsc143095

pirazofurin

pyrazofurin

PYRAZOFURIN MONOHYDRATE

4-HYDROXY-3-BETA-D-RIBOFURANOSYL-1H-PYRAZOLE-5-CARBOXAMIDE MONOHYDRATE

47599

A-23813

1H-Pyrazole-5-carboxamide, 4-hydroxy-3-beta-D-ribofuranosyl-

4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide

PRZF

Pyrazole-3-carboxamide, 4-hydroxy-5-beta-L-ribofuranosyl-

Pyrazomycin

Pyrozofurin

1H-Pyrazole-5-carboxamide, 4-hydroxy-3-β-D-ribofuranosyl-

β-Pyrazofurin

--Pyrazofurin

Pyrazomycin Ⅰ

3-((2S,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxy-1H-pyrazole-5-carboxamide

30868-30-5

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