2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

Product Name: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
CAS No.: 65872-41-5
Chemical Name: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid
Synonyms: AMAA;ATMA;ATMAA;Cefepime EP Impurity D;ATMIA;-4-yL;ATMAA CAS;Ansaxime acid;ThiazoxiMic Acid;Aminotaxime acid
CBNumber: CB5294497
Molecular Formula: C6H7N3O3S
Formula Weight: 201.2
MOL File: 65872-41-5.mol

More

Less

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Property

Melting point:: 192 °C (dec.)(lit.)
Boiling point:: 425.1±37.0 °C(Predicted)
Density: 1.463 (estimate)
refractive index: 1.6630 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
pka: 2.97±0.10(Predicted)
form: solid
color: White to Off-White
Water Solubility: 0.6 g/100 mL (20 ºC)
λmax: 273nm(MeOH)(lit.)
InChI: InChI=1S/C6H7N3O3S/c1-12-9-4(5(10)11)3-2-13-6(7)8-3/h2H,1H3,(H2,7,8)(H,10,11)/b9-4+
InChIKey: NLARCUDOUOQRPB-RUDMXATFSA-N
SMILES: C1(=CSC(N)=N1)/C(/C(=O)O)=N\OC
CAS DataBase Reference: 65872-41-5(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-24/25
WGK Germany: 3
HS Code: 29349990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2851
Product name: Cefepime Related Compound D
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 50MG
Price: $616
Updated: 2025/07/31

Sigma-Aldrich

Product number: 280143
Product name: 2-Amino-α-(methoxyimino)-4-thiazoleacetic acid, predominantly syn
Purity: 97%
Packaging: 5g
Price: $41.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1097680
Product name: 2-Amino-α-(methoxyimino)-4-thiazoleacetic acid, predominantly syn
Packaging: 20mg
Price: $1380
Updated: 2024/03/01

TCI Chemical

Product number: A2478
Product name: (Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $39
Updated: 2025/07/31

TCI Chemical

Product number: A2478
Product name: (Z)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic Acid
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $77
Updated: 2025/07/31

More

Less

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Chemical Properties,Usage,Production

Chemical Properties

OFF-WHITE TO BEIGE POWDER

Uses

Intermediate in the preparation of Cephem compounds.

Synthesis

64485-88-7

65872-41-5

General procedure for the synthesis of aminothiazole acid from ethyl (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate (Example 2): in a 250 ml reaction vial, 45.9 g (0.2 mol) of ethyl (Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetate was suspended in 200 ml of ethanol, followed by the addition of 1 N sodium hydroxide aqueous solution. The reaction mixture was stirred at room temperature for 15 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7.0 with 10% aqueous hydrochloric acid, followed by distillation under reduced pressure to remove the ethanol. The aqueous phase was washed with ethyl acetate and the pH was adjusted again with 10% aqueous hydrochloric acid to 2.8. Stirring was carried out under cooling conditions in an ice bath to induce the precipitation of crystals. The crystals were separated by filtration, washed with acetone and finally recrystallized from ethanol to give 22.9 g of 2-(2-aminothiazol-4-yl)-2-(Z)-methoxyiminoacetic acid in 57.0% yield.

References

[1] Patent: EP859002, 1998, A1

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Preparation Products And Raw materials

Raw materials

Thiourea

Preparation Products

Cefotaxime sodium

More

Less

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid Suppliers

Americas 1 Belgium 2 Canada 2 China 321 Europe 3 France 1 Germany 3 India 15 Japan 3 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 13 United States 38 Global 407

TCI Chemicals (India) Pvt. Ltd.

Tel: --
Fax: --
Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

Aavyan Labs

Tel: --
Fax: --
Email: sales@aavyanlabs.com
Country: India
ProdList: 19
Advantage: 58

Scinva Chemicals and Pharmaceuticals Pvt Ltd

Tel: --
Fax: --
Email: murthy@scinvapharma.com
Country: India
ProdList: 26
Advantage: 58

Clearsynth Labs

Tel: --
Fax: --
Email: fo@clearsynth.com
Country: India
ProdList: 3887
Advantage: 58

Pharma Affiliates

Tel: --
Fax: --
Email: @pharmaffiliates.com
Country: India
ProdList: 6754
Advantage: 58

Pharmaffiliates Analytics & Synthetics (P) Ltd.

Tel: --
Fax: --
Email: g@pharmaffiliates.com
Country: India
ProdList: 631
Advantage: 58

Reax Chemicals

Tel: --
Fax: --
Country: India
ProdList: 4217
Advantage: 58

Aditya Molecules

Tel: --
Fax: --
Country: India
ProdList: 95
Advantage: 58

AVIK PHARMACEUTICAL LIMITED

Tel: --
Fax: --
Email: kuldip@avikpharma.com
Country: India
ProdList: 54
Advantage: 58

Pharmaffiliates Analytics and Synthetics P. Ltd

Tel: --
Fax: --
Email: mktg@pharmaffiliates.com
Country: India
ProdList: 6739
Advantage: 58

SynZeal Research Pvt Ltd

Tel: --
Fax: --
Email: standards@synzeal.com
Country: India
ProdList: 6514
Advantage: 58

A.J Chemicals

Tel: --
Fax: --
Email: sales@ajchem.in
Country: India
ProdList: 6100
Advantage: 58

More

Less

View Lastest Price from 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid 65872-41-5
Price: US $0.00-0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-11-25

Hebei Jingbo New Material Technology Co., Ltd

Product: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid 65872-41-5
Price: US $9.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-11-29

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid 65872-41-5
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-24

65872-41-5, 2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acidRelated Search:

Cefotaxime Ethyl 3-aminopropanoate hydrochloride Cefotaxime sodium Glycine Iminodiacetic acid 4-Aminophenylacetic acid 2-(2-Aminothiazol-4-yl)glyoxylic acid Nitrilotriacetic acid 2-Aminothiazole Cefoxitin Impurity 3 Tenofovir Impurity 92 Teprenone 1-Methylpyrrolidine T 2588G CefepiMe interMediate (7-PIME) Cefepime EP Impurity F Cefepime Impurity A α-Lipoic Acid

2-Amino-<i>α</i>-(methoxyimino)-4-thiazoleacetic acid

(<i>Z</i>)-2-(2-Amino-4-thiazolyl)-2-(methoxyimino)acetic Acid

2-aminothiazole-methoxyiminoaceticacid

2-Methoxylimino-2-(2-aminothiozol)-4-aceticacid

ATMIA

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid(ATMMA)

(Z)-2-methoxyimino-2-(2-aminothiazol-4-yl)Acetic acid anhydrous

2-(2-AMINO-4-THIAZOL)-2-METHOXIMINOACETIC ACID

(Z)-2-(2-Aminothiazol-4-yl)-2-

2-amino-α-(methoxyimino)-4-thiazoleacetic acid, predominantly syn

2-(2-amino-4-thiazolyl)-2-methoxyiminoacetic acid

(Z)-2-METHOXYIMINO-2-(2-AMINOTHIAZOLE-4-YL-)-ACETIC ACID ANHYDROUS/ATMAA

ATMAA CAS

ATMIA:2-(2-AMINO-4-THIAZOLYL)-2-METHOXYIMINOACETIC ACID

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid (AMAA)

（Z）-2-methoxyimino-2-(2-aminothiazole)-4-acetic acid

2-AMINO-ALPHA-(METHOXYIMINO)-4-THIAZOLE ACETIC ACI

(Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetic acid

4-THIAZOLEACETICACID,2-AMINO-A-(METHOXYIMINO)-

ATIFICIALCOW-BEZOAR

(Z)-2-AMINO-ALPHA-METHOXYIMINO-4-THIAZOLEACETIC ACID

(Z)-2-AMINO-A-(METHOXYIMINO)-4-THIAZOLEACETIC ACIDCEFOTAXIME

2-AMINO-A-(METHOXYIMINO)-4-THIAZOLEACETIC ACID

2-AMINO-A-(METHOXYIMINO)-4-THIAZOLEACETIC ACIDB-LACTAMASE INHIBITOR

(z)-2-(2-Aminothiazol-4-yl)-2-methoxyimino acetic acid Anhydrous

2-AMINO-ALPHA-(METHOXYIMINO)-4-THIAZOLE- ACETIC ACID, 97%, PREDOMINANTLY SYN

AMAA

(Z)-2-(2-Aminothiazol-4-Yl)-2-MethoxyiminoAceticAcidAnhydrous(Atmaa)

Tiotropium Bromide 139404-48-1 (Z)-2-(2-Aminothiazol-4-Yl)-2-Methoxyimino Acetic Acid Anhydrous ( Atmaa )

(Z)-(2-Aminothiazol-4-yl)-a-(methoxyimino)acetic acid

(Z)-2-Amino-a-(methoxyimino)-4-thiazoleacetic acid

2-(2-Amino-4-thiazolyl)-(Z)-2-methoxyiminoacetic acid

2-Methoxylimino-2-(2-aminothiazolyl)-4-acetic acid

(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid

Aminothiaoximinoacid

Aminothiaoximoacid

2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINOACETIC ACID

4-THIAZOLEACETIC ACID, 2-AMINO-ALPHA-(METHOXYIMINO)-

(Z)-2-(2-AMINOTHIAZOLE-4-YL)-2-METHOXYIMINO ACETIC ACID

(Z)-2-(2-AMINOTHIAZOL-4-YL)-2-METHOXYIMINOACETIC ACID

(Z)-2-Methoxyimino-2-(2-Amino-Thiazole-4-Yl-)-Acetic Acid Anhydrous

2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoacetic acid

syn-2-(2-Aminothiazol-4-yl)-2-methoxyiminoacetic acid

syn-Thiazoximic acid

2-(2-Aminothiazole-4-yl)-2-methoxyiminoacetic acid ,98%

(2-Aminothiazol-4-yl)[(Z)-methoxyimino]acetic acid

2-amino-alpha-(methoxyimino)-4-thiazoleacetate

2-(2-Amino-4-thiazoly)-2-methoxyiminoacetic acid

2-(2-Aminothiazole-4-yl)-2-methoxyiminoaceticacid,97%

2-Amino-alpha-(methoxyimino)-4-thiazoleacetic acid

2-Amino-α-(methoxyimino)-4-thiazoleacetic Acid

(z)-(2-aminothiazole-4-yl)-2-methoxyiminoacetic acid

ATMAA

ATMA

(Z)-2-amino-alpha-(methoxyimino)thiazol-4-acetic acid

2-(2-AMinothiazole-4-yl)-2-MethoxyiMinoacetic acid, predoMinantly syn

ThiazoxiMic Acid

2-(2-aMino-1,3-thiazol-4-yl)-2-(MethoxyiMino)acetic acid