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Benidipine hydrochloride

Product Name
Benidipine hydrochloride
CAS No.
91599-74-5
Chemical Name
Benidipine hydrochloride
Synonyms
(3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1);Conipros;Benidipin;rac-Benidipine HCl;Benidipine hydrochlo;Benidipine Impurity 4;Benidipine hydrochloride;rac Benidipine Hydrochloride;Benidipine hydrochloride USP/EP/BP;(R,R)(S,S)-Benidipine Hydrochloride
CBNumber
CB5294563
Molecular Formula
C28H31N3O6.HCl
Formula Weight
542.02
MOL File
91599-74-5.mol
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Benidipine hydrochloride Property

Melting point:
199-201°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: ≥20mg/mL
pka
7.34(at 25℃)
form 
powder
color 
yellow
InChIKey
DGVVISBYHUXFIU-UHFFFAOYSA-N
CAS DataBase Reference
91599-74-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
US7975657
HS Code 
2933.99.5300
Toxicity
LD50 orally in male mice: 218 mg/kg (Muto, 1988)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B6813
Product name
Benidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$91.6
Updated
2024/03/01
Sigma-Aldrich
Product number
B6813
Product name
Benidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$354
Updated
2024/03/01
TCI Chemical
Product number
B5629
Product name
Benidipine Hydrochloride
Packaging
100MG
Price
$26
Updated
2024/03/01
TCI Chemical
Product number
B5629
Product name
Benidipine Hydrochloride
Packaging
1G
Price
$237
Updated
2024/03/01
Cayman Chemical
Product number
21607
Product name
Benidipine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$37
Updated
2024/03/01
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Benidipine hydrochloride Chemical Properties,Usage,Production

Description

Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.

Description

Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.

Chemical Properties

Yellow Crystalline Powder

Originator

Kyowa Hakko (Japan)

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

brand name

Coniel

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Safety Profile

A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.

storage

room temperature (desiccate)

Benidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Benidipine hydrochloride Suppliers

Americas 1 Canada 4 CHINA 187 Europe 3 France 1 Germany 4 India 24 Italy 1 Japan 4 South Korea 2 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 36 Global 280
Carbosynth
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KEMPROTEC Limited
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Key Organics Ltd.
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Melrob Ltd (part of Nordmann)
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Biokemix
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Bio-Techne Ltd. (Tocris Bioscience)
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Tocris Bioscience
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CARBONE SCIENTIFIC CO.,LTD
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Eurolabs Limited
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ETA SCIENTIFIC Co.,Ltd
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UK GREEN SCIENTIFIC CO.,LIMITED
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sales@gs-chem.com
Country
United Kingdom
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View Lastest Price from Benidipine hydrochloride manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Benidipine hydrochloride 91599-74-5
Price
US $1050.00/g/Bag
Min. Order
100g
Purity
99%
Supply Ability
10kg
Release date
2021-06-03
Zhuozhou Wenxi import and Export Co., Ltd
Product
Benidipine hydrochloride 91599-74-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
Benidipine hydrochloride 91599-74-5
Price
US $1050.00/g
Min. Order
100g
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-03

91599-74-5, Benidipine hydrochlorideRelated Search:

DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Chromium picolinate Topotecan hydrochloride Benidipine Dimethyl sulfoxide N,N-Dimethylformamide Dihydromyrcenol ETHANE Dimethyl ether Quinolinic acid Lercanidipine hydrochloride Dimethyl phthalate Benzyldimethylcarbinyl butyrate Dimethylbenzylcarbinyl acetate Manidipine hydrochloride Pyridine Dimethyl sulfide Dimethyl fumarate

  • (R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT
  • Coniel, Capadipine, KW-3049, Nacadipine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-
  • (R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride
  • Benidipine hydrochloride
  • monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste
  • 1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE
  • 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-DimethoxyCarboxylate
  • (R,R)-(+/)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidmethyl-1-(phenylmethyl)-3-piperidiny
  • rac-Benidipine HCl
  • Benidipine hydrochlo
  • (4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1)
  • (4R)-rel-3,5-Pyridinedicarboxylic acid
  • 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester
  • Conipros
  • rac-(4R*)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R*)-1-benzylpiperidine-3-yl]·hydrochloride
  • (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid3-methyl5-[(3R)-1-(phenylmethyl)-3-piperidinyl]esterhydrochloride
  • rac Benidipine Hydrochloride
  • Benidipine Impurity 4
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-
  • (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
  • 3-[(3RS)-1-Benzylpiperidin-3-yl] 5-Methyl (4RS)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
  • Benidipine hydrochloride USP/EP/BP
  • (R)-rel-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
  • 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride
  • 3-[(R*)-1-Benzylpiperidin-3-yl] (R*)-5-Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
  • Benidipin
  • (R,R)(S,S)-Benidipine Hydrochloride
  • (±)-(R*)-3-[(R*)-1-Benzyl-3-piperidyl]methyl 1,4-dihydro-2,6-dimethyl- 4-(m-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride
  • (3R*)-1-Benzylpiperidin-3-yl methyl (4R*)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Cocaine Hydrochloride Impurity 3(Cocaine Hydrochloride EP Impurity C )(β-Truxilline)
  • 91599-74-5
  • 91599-47-5
  • C28H32ClN3O6
  • C28H31N3O6
  • Inhibitors
  • Antihypertensive
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Chiral Reagents
  • Heterocycles