ChemicalBook > CAS DataBase List > Benidipine hydrochloride

Benidipine hydrochloride

Product Name
Benidipine hydrochloride
CAS No.
91599-74-5
Chemical Name
Benidipine hydrochloride
Synonyms
(3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1);Conipros;Benidipin;rac-Benidipine HCl;Benidipine hydrochlo;Benidipine Impurity 4;Benidipine hydrochloride;rac Benidipine Hydrochloride;Benidipine hydrochloride USP/EP/BP;Benidipine hydrochloride - Bio-X ?
CBNumber
CB5294563
Molecular Formula
C28H31N3O6.HCl
Formula Weight
542.02
MOL File
91599-74-5.mol
More
Less

Benidipine hydrochloride Property

Melting point:
199-201°C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: ≥20mg/mL
pka
7.34(at 25℃)
form 
powder
color 
yellow
InChIKey
DGVVISBYHUXFIU-UHFFFAOYSA-N
SMILES
C(C1=C(NC(=C([C@H]1C1C=CC=C(C=1)N(=O)=O)C(=O)OC)C)C)(=O)O[C@@H]1CCCN(C1)CC1C=CC=CC=1.Cl
CAS DataBase Reference
91599-74-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
US7975657
HS Code 
2933.99.5300
HazardClass 
6.1
Toxicity
LD50 orally in male mice: 218 mg/kg (Muto, 1988)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B6813
Product name
Benidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$80.1
Updated
2025/07/31
Sigma-Aldrich
Product number
B6813
Product name
Benidipine hydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$309
Updated
2025/07/31
TCI Chemical
Product number
B5629
Product name
Benidipine Hydrochloride
Packaging
100MG
Price
$23
Updated
2025/07/31
TCI Chemical
Product number
B5629
Product name
Benidipine Hydrochloride
Packaging
1G
Price
$213
Updated
2025/07/31
Cayman Chemical
Product number
21607
Product name
Benidipine (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$37
Updated
2024/03/01
More
Less

Benidipine hydrochloride Chemical Properties,Usage,Production

Description

Benidipine hydrochloride is a new, long acting dihydropyridine calcium antagonist useful in the treatment of hypertension and angina pectoris. In experimental animals, benidipine hydrochloride dose dependently induced hypotension with a potency of 6 and 12 times more than nifedipine and nicardipine, respectively. It also exhibited a slow onset of action.

Description

Benidipine is an orally bioavailable blocker of L-, T-, and N-type calcium channels. In guinea pig ventricular cells benidipine has an IC50 of 2.7 nM for calcium currents, determined using whole cell voltage clamp electrophysiology. It prevents oxidative stress dose-dependently in vitro, decreases blood pressure in spontaneously hypertensive rats (at 3 and 10 mg/kg), and is neuroprotective for neural stem cells after oxidative stress-induced injury. Benidipine is also a competitive antagonist at mineralocorticoid receptors.

Chemical Properties

Yellow Crystalline Powder

Originator

Kyowa Hakko (Japan)

Uses

A dihydropyridine calcium channel blocker. Antihypertensive.

brand name

Coniel

Biological Activity

Orally active antihypertensive agent which displays a wide range of activities in vitro and in vivo . Inhibits L-, N- and T-type Ca 2+ channels. Also inhibits aldosterone-induced mineralocorticoid receptor activation. Exhibits cardioprotective and antiartherosclerotic effects.

Safety Profile

A poison by ingestion,intraperitoneal, and intravenous routes. When heated todecomposition it emits toxic vapors of NOx and HCl.

Synthesis

14813-01-5

74936-72-4

91599-74-5

Under sonication conditions, 10 g of monomethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate was placed in a 200 mL reaction flask, to which 14 mL of N,N-dimethylformamide (DMF) and 56 mL of dichloromethane were added. Under ice bath conditions, 2.4 mL of thionyl chloride was slowly added to the resulting homogeneous suspension, followed by stirring the reaction mixture for 1 hour until a clarified solution was formed. Next, 6.3 g of 1-benzyl-3-piperidinol was added and stirring was continued for 2.5 hours under ice bath conditions. Upon completion of the reaction, the reaction solution was washed with 40 mL of water (repeated 4 times) and 40 mL of saturated brine solution (1 time). The organic phase was dried by adding 4 g of anhydrous sodium sulfate for 2 hours. After drying, the sodium sulfate solid was removed by filtration and the dichloromethane was recovered by distillation under reduced pressure to give the crude yellow to red (R)-rel-3-((R)-1-benzylpiperidin-3-yl)5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride. The crude product was dissolved in 100 mL of acetone and sonicated at 150 W and 40 kHz for 7 min, followed by filtration under reduced pressure and drying to give 5.9 g of yellow powdery product in 36.2% yield.

storage

room temperature (desiccate)

References

[1] Patent: WO2012/142815, 2012, A1. Location in patent: Page/Page column 5; 6

Benidipine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Benidipine hydrochloride Suppliers

Americas 1 Canada 4 CHINA 236 Europe 3 France 1 Germany 4 India 24 Italy 1 Japan 4 South Korea 2 Switzerland 1 The Netherlands 1 United Kingdom 11 United States 36 Global 329
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Cato Research Chemicals Inc.
Tel
+86-020-81960175-877 4000-868-328
Email
tianwen.zhan@cato-chem.com
Country
United States
ProdList
10404
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
CacheSyn Inc.
Tel
--
Fax
--
Email
info@cachesyn.com
Country
United States
ProdList
695
Advantage
50
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Crescent Chemical Company
Tel
--
Fax
--
Email
fran@creschem.com
Country
United States
ProdList
1441
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Santa Cruz Biotechnology, Inc.
Tel
--
Fax
--
Email
scbt@scbt.com
Country
United States
ProdList
3597
Advantage
60
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Medical Isotopes
Tel
--
Fax
--
Email
stohler@medicalisotopes.com
Country
United States
ProdList
6181
Advantage
68
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Davos Chemical Corporation
Tel
--
Fax
--
Email
info@davos.com
Country
United States
ProdList
1640
Advantage
65
More
Less

View Lastest Price from Benidipine hydrochloride manufacturers

Guangzhou Tosun Pharmaceutical Ltd
Product
Benidipine hydrochloride 91599-74-5
Price
US $0.00-0.00/mg
Min. Order
5mg
Purity
95%+
Supply Ability
1000mg
Release date
2024-12-30
Baoji Guokang Healthchem Co., Ltd.
Product
Benidipine hydrochloride 91599-74-5
Price
US $1050.00/g/Bag
Min. Order
100g
Purity
99%
Supply Ability
10kg
Release date
2021-06-03
Shaanxi Dideu New Materials Co. Ltd
Product
Benidipine hydrochloride 91599-74-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10000KGS
Release date
2025-02-18

91599-74-5, Benidipine hydrochlorideRelated Search:

DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Chromium picolinate Topotecan hydrochloride Benidipine Dimethyl sulfoxide N,N-Dimethylformamide Dihydromyrcenol ETHANE Dimethyl ether Quinolinic acid Lercanidipine hydrochloride Dimethyl phthalate Benzyldimethylcarbinyl butyrate Dimethylbenzylcarbinyl acetate Manidipine hydrochloride Pyridine Dimethyl sulfide Dimethyl fumarate

  • (R,R)-(+/-)-2,6-DIMETHYL-4-(3-NITROPHENYL)-1,4-DIHYDRO-3,5-PYRIDINE,DICARBOXYLIC ACID METHYL-1-BENZYL-3-PIPERIDYL-ESTER,MONOHYDROCHLORIDE SALT
  • Coniel, Capadipine, KW-3049, Nacadipine
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl (3R)-1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (4R)-rel-
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 1-(phenylmethyl)-3-piperidinyl ester, monohydrochloride, (R*,R*)-(+-)-
  • (R,R)-(+/-)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-Dihydro-3,5-pyridine-dicarboxylic acid methyl-1-benzyl-3-piperidyl-ester hydrochloride
  • Benidipine hydrochloride
  • monohydrochloride,(r*,r*)-(+-)-hyl1-(phenylmethyl)-3-piperidinyleste
  • 1-(BENZYLMETHYL)-3-PIPERIDINYL 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-3,5-PYRIDINEDICARBOLATE
  • 2,6-Dimethyl-4-(3-Nitrophenyl)-1,4-Dihydropyridine-3,5-DimethoxyCarboxylate
  • (R,R)-(+/)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacidmethyl-1-(phenylmethyl)-3-piperidiny
  • rac-Benidipine HCl
  • Benidipine hydrochlo
  • (4R)-rel-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester, hydrochloride (1:1)
  • (4R)-rel-3,5-Pyridinedicarboxylic acid
  • 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester
  • Conipros
  • rac-(4R*)-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 3-methyl 5-[(3R*)-1-benzylpiperidine-3-yl]·hydrochloride
  • (4R)-rel-1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylicacid3-methyl5-[(3R)-1-(phenylmethyl)-3-piperidinyl]esterhydrochloride
  • rac Benidipine Hydrochloride
  • Benidipine Impurity 4
  • 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-diMethyl-4-(3-nitrophenyl)-, 3-Methyl5-[(3R)-1-(phenylMethyl)-3-piperidinyl] ester, hydrochloride (1:1), (4R)-rel-
  • (3R)-1-Benzyl-3-piperidinyl methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate hydrochloride (1:1)
  • 3-[(3RS)-1-Benzylpiperidin-3-yl] 5-Methyl (4RS)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
  • Benidipine hydrochloride USP/EP/BP
  • (R)-rel-3-((R)-1-Benzylpiperidin-3-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
  • 5-O-[(3R)-1-benzylpiperidin-3-yl] 3-O-methyl (4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate,hydrochloride
  • 3-[(R*)-1-Benzylpiperidin-3-yl] (R*)-5-Methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Hydrochloride
  • Benidipin
  • (R,R)(S,S)-Benidipine Hydrochloride
  • (±)-(R*)-3-[(R*)-1-Benzyl-3-piperidyl]methyl 1,4-dihydro-2,6-dimethyl- 4-(m-nitrophenyl)-3,5-pyridinedicarboxylate hydrochloride
  • (3R*)-1-Benzylpiperidin-3-yl methyl (4R*)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
  • Cocaine Hydrochloride Impurity 3(Cocaine Hydrochloride EP Impurity C )(β-Truxilline)
  • Benidipine hydrochloride, 10 mM in DMSO
  • Benidipine hydrochloride - Bio-X ?
  • 91599-74-5
  • 91599-47-5
  • C28H32ClN3O6
  • C28H31N3O6
  • Inhibitors
  • Antihypertensive
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics
  • Chiral Reagents
  • Heterocycles