ChemicalBook > CAS DataBase List > Bis(4-cyanophenyl)methanol
Bis(4-cyanophenyl)methanol
- Product Name
- Bis(4-cyanophenyl)methanol
- CAS No.
- 134521-16-7
- Chemical Name
- Bis(4-cyanophenyl)methanol
- Synonyms
- CGP 44645;4-[-(4-Cyanopheny;-Dicyanobenzhydrol;Letrozole Impurity 6;4,4'-dicyanobenzhydrol;BIS(4-CYANOPHENYL)METHANOL;Bis(p-cyanophenyl)Methanol;Bis(4-cyanophenyl)methanol, >=96%;Bis (4-cyanophenyl) methanol (DCM);4,4,-(hydroxymethylene)dibenzonitrile
- CBNumber
- CB5296769
- Molecular Formula
- C15H10N2O
- Formula Weight
- 234.25
- MOL File
- 134521-16-7.mol
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Bis(4-cyanophenyl)methanol Property
- Melting point:
- 158-159 °C
- Boiling point:
- 473.5±45.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.80±0.20(Predicted)
- form
- Solid
- color
- Light Brown
- Stability:
- Light Sensitive
- CAS DataBase Reference
- 134521-16-7(CAS DataBase Reference)
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Safety
- HS Code
- 29269090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 21316
- Product name
- 4,4'-Dicyanobenzhydrol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21316
- Product name
- 4,4'-Dicyanobenzhydrol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21316
- Product name
- 4,4'-Dicyanobenzhydrol
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $379
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21316
- Product name
- 4,4'-Dicyanobenzhydrol
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $713
- Updated
- 2024/03/01
TRC
- Product number
- B422850
- Product name
- Bis(4-cyanophenyl)methanol
- Packaging
- 5mg
- Price
- $135
- Updated
- 2021/12/16
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Bis(4-cyanophenyl)methanol Chemical Properties,Usage,Production
Uses
A metabolite of Letrozole
Definition
ChEBI: 4,4'-methanol-bisbenzonitrile is a diarylmethane.
Synthesis
623-00-7
105-07-7
134521-16-7
General procedure for the synthesis of bis(4-cyanophenyl)methanol from 4-bromobenzonitrile and 4-cyanobenzaldehyde: A THF solution (4 ml) of 4-bromobenzonitrile (1.4 g, 7.6 mmol) was slowly added dropwise to a THF solution (10.5 ml) of 1.3 M of the 1PrMgCl LiCl complex at -15 °C, the dropwise addition process continued for 15 min. The resulting brown solution was stirred at -15°C for 30 minutes, followed by continued stirring at the same temperature for 1.5 hours. Subsequently, the solution was slowly added dropwise to a THF solution (4 ml) of 4-cyanobenzaldehyde (1.0 g, 7.6 mmol) at -15°C and the dropwise process was continued for 10 minutes. The reaction mixture was stirred at 0°C for 1 h and then the reaction was quenched with saturated aqueous NH4Cl solution (20 ml). Extraction was carried out by adding TBME (30 ml) and water (20 ml). After separation of the organic layer, the aqueous phase was further extracted with TBME (2 x 20 ml). The organic layers were combined, washed with saturated aqueous NaCl, dried over anhydrous Na2SO4 and concentrated under reduced pressure. To the crude product (2 g) was added EtOAc/heptane (1:2) mixed solvent. The insoluble light yellow solid (0.54 g) was collected by filtration, dissolved in diethyl ether and precipitated with pentane to give a light yellow solid product 10u (0.49 g, 27.5% yield). The mother liquor was concentrated under reduced pressure and purified by rapid chromatography on silica gel (eluent: EtOAc/heptane, 1:2) to give an additional light yellow solid product 10u (0.23 g, 13% yield).
References
[1] Patent: WO2015/189265, 2015, A1. Location in patent: Page/Page column 121
Bis(4-cyanophenyl)methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Bis(4-cyanophenyl)methanol manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Bis(4-cyanophenyl)methanol 134521-16-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- Bis(4-cyanophenyl)methanol 134521-16-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09
Career Henan Chemical Co
- Product
- Bis(4-cyanophenyl)methanol 134521-16-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24
134521-16-7, Bis(4-cyanophenyl)methanolRelated Search:
Tris(hydroxymethyl)nitromethane
Sodium cyanoborohydride
Ethyl cyanoacetate
Diethylstilbestrol
Cyanoacetic acid
Ethyl cyanoformate
ETHYL 2-CYANOACRYLATE
4-Cyanophenol
Benzonitrile
Methanol
4-Nitrobenzonitrile
Methylene dithiocyanate
4-(HYDROXYMETHYL)BENZONITRILE
Benzonitrile, 4-[(1S)-1-hydroxyethyl]- (9CI)
Benzonitrile, 4-[(1R)-1-hydroxyethyl]- (9CI)
4,4'-(1-METHYLENE) BIS-BENZONITRILE
Glycolonitrile
Letrozole