ChemicalBook > CAS DataBase List > 2-Fluorophenylacetic acid

2-Fluorophenylacetic acid

Product Name
2-Fluorophenylacetic acid
CAS No.
451-82-1
Chemical Name
2-Fluorophenylacetic acid
Synonyms
O-fluorine acid;RARECHEM AL BO 0110;2-Fluorophenylacetic;o-flurophenylacetic acid;2-Fluorphenylessigsaeure;2-fluoro-benzeneaceticaci;2-FLUOROPHENYLACETIC ACID;O-FLUOROPHENYLACETIC ACID;2-fluoro-benzeneacetic acid;2-Fluorophenylaceticacid97%
CBNumber
CB5297100
Molecular Formula
C8H7FO2
Formula Weight
154.14
MOL File
451-82-1.mol
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2-Fluorophenylacetic acid Property

Melting point:
60-62 °C (lit.)
Boiling point:
203.5°C (rough estimate)
Density 
1.1850 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Solid
pka
4.01±0.10(Predicted)
color 
Off-White
BRN 
775955
InChI
InChI=1S/C8H7FO2/c9-7-4-2-1-3-6(7)5-8(10)11/h1-4H,5H2,(H,10,11)
InChIKey
RPTRFSADOICSSK-UHFFFAOYSA-N
SMILES
C1(CC(O)=O)=CC=CC=C1F
CAS DataBase Reference
451-82-1(CAS DataBase Reference)
NIST Chemistry Reference
O-fluorophenylacetic acid(451-82-1)
EPA Substance Registry System
Benzeneacetic acid, 2-fluoro- (451-82-1)
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Safety

Hazard Codes 
Xi
Risk Statements 
38-36/37/38
Safety Statements 
22-24/25-36/37/39-27-26
WGK Germany 
3
F 
13
TSCA 
T
HazardClass 
IRRITANT
HS Code 
29163990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
208949
Product name
2-Fluorophenylacetic acid
Purity
98%
Packaging
10g
Price
$103
Updated
2023/06/20
TCI Chemical
Product number
F0205
Product name
2-Fluorophenylacetic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$27
Updated
2024/03/01
TCI Chemical
Product number
F0205
Product name
2-Fluorophenylacetic Acid
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$70
Updated
2024/03/01
Alfa Aesar
Product number
A10596
Product name
2-Fluorophenylacetic acid, 98+%
Packaging
10g
Price
$44.65
Updated
2024/03/01
Alfa Aesar
Product number
A10596
Product name
2-Fluorophenylacetic acid, 98+%
Packaging
50g
Price
$136.65
Updated
2024/03/01
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2-Fluorophenylacetic acid Chemical Properties,Usage,Production

Chemical Properties

white to off-white shiny crystals or crystalline

Uses

2-Fluorophenylacetic acid was used:

  • in the synthesis of thiazolino[3,2-c]pyrimidin-5,7-diones and N-[2-(3,4-dichlorophenyl)-ethyl]-N′-[2-(2-fluorophenyl)-ethyl]-ethane-1,2-diamine
  • as chiral derivatizing agent for determination of enantiomeric composition of chiral, nonracemic compounds by 19F NMR spectroscopy

General Description

2-Fluorophenylacetic acid is chiral derivatizing agent for determination of enantiomeric composition of chiral, nonracemic compounds by 19F NMR spectroscopy.

Synthesis

The Schlenk tube was heated under a high vacuum, pre-dried with calcium chloride, and filled with CO2 gas. Bis(4-methoxyphenyl)zinc magnesium chloride lithium chloride (12.8 ml, 0:39 M in THF, 5.0 mmol) was added, and CO2 was passed through the solution for 5 minutes. The reaction mixture was stirred at 25 °C for 6 hours. Diethyl ether (50 ml) was added, and the organic phase was extracted with 2M NaOH (3×50 ml). The combined aqueous phases were acidified with 2M HCl (pH <5) and extracted with diethyl ether (3×50 ml). The combined organic phases were dried over sodium sulfate, and the solvent was removed in vacuo. 2-Fluorophenylacetic acid was obtained in a yield of 100%.

2-Fluorophenylacetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Fluorophenylacetic acid Suppliers

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View Lastest Price from 2-Fluorophenylacetic acid manufacturers

Speranza Chemical Co., Ltd.
Product
2-Fluorophenylacetic acid 451-82-1
Price
US $170.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
200tons/ year
Release date
2020-03-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
2-Fluorophenylacetic acid 451-82-1
Price
US $9.00/KG
Min. Order
1KG
Purity
99.9
Supply Ability
1 ton
Release date
2024-08-20
Hebei Mojin Biotechnology Co.,Ltd
Product
2-Fluorophenylacetic acid 451-82-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-08-23

451-82-1, 2-Fluorophenylacetic acidRelated Search:

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