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Diethylenetriaminepentaacetic acid

Product Name
Diethylenetriaminepentaacetic acid
CAS No.
67-43-6
Chemical Name
Diethylenetriaminepentaacetic acid
Synonyms
DIPA;DTPA;PENTETIC ACID;DETP;DETPA;DETAPAC;DTRA;Detarex;CCDC85B;Chel 330
CBNumber
CB5303977
Molecular Formula
C14H23N3O10
Formula Weight
393.35
MOL File
67-43-6.mol
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Diethylenetriaminepentaacetic acid Property

Melting point:
219-220 °C (lit.)
Boiling point:
517.84°C (rough estimate)
Density 
1.56
refractive index 
1.5700 (estimate)
Flash point:
200 °C
storage temp. 
room temp
solubility 
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka
pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
form 
Crystalline Powder
color 
White to almost white
PH
2-3 (H2O, 20℃)(saturated solution)
Water Solubility 
5 g/L (20 ºC)
Merck 
14,7125
BRN 
1810219
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
QPCDCPDFJACHGM-UHFFFAOYSA-N
LogP
-1.361 (est)
CAS DataBase Reference
67-43-6(CAS DataBase Reference)
NIST Chemistry Reference
N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
EPA Substance Registry System
Pentetic acid (67-43-6)
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Safety

Hazard Codes 
Xi,N,Xn
Risk Statements 
36-51/53-36/37/38-20-63
Safety Statements 
26-36-61-37/39-36/37
RIDADR 
UN 3077 9/PG 3
WGK Germany 
2
RTECS 
MB8205000
F 
3
TSCA 
Yes
HazardClass 
9
PackingGroup 
III
HS Code 
29224995
Toxicity
LD50 orally in Rabbit: > 2000 mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

H332Harmful if inhaled

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2645
Product name
Pentetic Acid
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
200MG
Price
$186
Updated
2024/03/01
Sigma-Aldrich
Product number
32319
Product name
Diethylenetriaminepentaacetic acid
Purity
for complexometry, ≥99.0%
Packaging
100g
Price
$84.8
Updated
2024/03/01
Sigma-Aldrich
Product number
32319
Product name
Diethylenetriaminepentaacetic acid
Purity
for complexometry, ≥99.0%
Packaging
500g
Price
$353
Updated
2024/03/01
Sigma-Aldrich
Product number
1505506
Product name
Pentetic acid
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
100mg
Price
$436
Updated
2024/03/01
Sigma-Aldrich
Product number
1.08426
Product name
Titriplex® V
Purity
for analysis (diethylenetriaminepentaacetic acid)
Packaging
100g
Price
$138
Updated
2024/03/01
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Diethylenetriaminepentaacetic acid Chemical Properties,Usage,Production

Chemical Properties

Pentetic acid occurs as a white crystalline solid and is almost odorless.

Chemical Properties

Diethylenetriaminepentaacetic acid is a solid.

Uses

Diethylenetriaminepentaacetic acid is used as chelating agent and forms complexes with metal ions. It finds application as a magnetic resonance imaging (MRI) contrasting agent, since it improves the image by forming a complex with a gadolinium ion. It can also be used for treatment of radioactive materials such as plutonium, americium and other actinides. It is an active component of manganese and zinc fertilizers used in agrochemical industry. It acts as a color inhibitor and is used in the production of acrylon. It is also used in soaps as a water softener.

Uses

Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.

Uses

chelating agent, diagnostic aid

Production Methods

Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.

Definition

ChEBI: Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-).

General Description

Visit our Titration Center to learn more.

Pharmaceutical Applications

Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Safety

Pentetic acid is used in intrathecal and intravenous injection preparations. The pure form of pentetic acid is moderately toxic by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg

storage

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Purification Methods

Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]

Incompatibilities

The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.

Regulatory Status

Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.

Diethylenetriaminepentaacetic acid Preparation Products And Raw materials

Raw materials

Diethylenetriamine Formaldehyde Sodium cyanide Hydrochloric acid

Preparation Products

DIETHYLENETRIAMINEPENTAACETIC DIANHYDRIDE
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View Lastest Price from Diethylenetriaminepentaacetic acid manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Diethylenetriaminepentaacetic acid 67-43-6
Price
US $25.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/week
Release date
2024-04-25
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
(Carboxymethylimino)bis(ethylenenitrilo)tetraacetic acid 67-43-6
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-22
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Diethylenetriamine pentaacetic acid 67-43-6
Price
US $70.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-31

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