Diethylenetriaminepentaacetic acid
- Product Name
- Diethylenetriaminepentaacetic acid
- CAS No.
- 67-43-6
- Chemical Name
- Diethylenetriaminepentaacetic acid
- Synonyms
- DIPA;DTPA;PENTETIC ACID;DETP;DETPA;DETAPAC;DTRA;Detarex;CCDC85B;Chel 330
- CBNumber
- CB5303977
- Molecular Formula
- C14H23N3O10
- Formula Weight
- 393.35
- MOL File
- 67-43-6.mol
Diethylenetriaminepentaacetic acid Property
- Melting point:
- 219-220 °C (lit.)
- Boiling point:
- 517.84°C (rough estimate)
- Density
- 1.56
- refractive index
- 1.5700 (estimate)
- Flash point:
- 200 °C
- storage temp.
- room temp
- solubility
- 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
- pka
- pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C)
- form
- Crystalline Powder
- color
- White to almost white
- PH
- 2-3 (H2O, 20℃)(saturated solution)
- Water Solubility
- 5 g/L (20 ºC)
- Merck
- 14,7125
- BRN
- 1810219
- Stability:
- Stable. Incompatible with strong oxidizing agents.
- InChIKey
- QPCDCPDFJACHGM-UHFFFAOYSA-N
- LogP
- -1.361 (est)
- CAS DataBase Reference
- 67-43-6(CAS DataBase Reference)
- NIST Chemistry Reference
- N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6)
- EPA Substance Registry System
- Pentetic acid (67-43-6)
Safety
- Hazard Codes
- Xi,N,Xn
- Risk Statements
- 36-51/53-36/37/38-20-63
- Safety Statements
- 26-36-61-37/39-36/37
- RIDADR
- UN 3077 9/PG 3
- WGK Germany
- 2
- RTECS
- MB8205000
- F
- 3
- TSCA
- Yes
- HazardClass
- 9
- PackingGroup
- III
- HS Code
- 29224995
- Toxicity
- LD50 orally in Rabbit: > 2000 mg/kg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
H332Harmful if inhaled
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PHR2645
- Product name
- Pentetic Acid
- Purity
- Pharmaceutical Secondary Standard; Certified Reference Material
- Packaging
- 200MG
- Price
- $186
- Updated
- 2024/03/01
- Product number
- 32319
- Product name
- Diethylenetriaminepentaacetic acid
- Purity
- for complexometry, ≥99.0%
- Packaging
- 100g
- Price
- $84.8
- Updated
- 2024/03/01
- Product number
- 32319
- Product name
- Diethylenetriaminepentaacetic acid
- Purity
- for complexometry, ≥99.0%
- Packaging
- 500g
- Price
- $353
- Updated
- 2024/03/01
- Product number
- 1505506
- Product name
- Pentetic acid
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 100mg
- Price
- $436
- Updated
- 2024/03/01
- Product number
- 1.08426
- Product name
- Titriplex® V
- Purity
- for analysis (diethylenetriaminepentaacetic acid)
- Packaging
- 100g
- Price
- $138
- Updated
- 2024/03/01
Diethylenetriaminepentaacetic acid Chemical Properties,Usage,Production
Chemical Properties
Pentetic acid occurs as a white crystalline solid and is almost odorless.
Chemical Properties
Diethylenetriaminepentaacetic acid is a solid.
Uses
Diethylenetriaminepentaacetic acid is used as chelating agent and forms complexes with metal ions. It finds application as a magnetic resonance imaging (MRI) contrasting agent, since it improves the image by forming a complex with a gadolinium ion. It can also be used for treatment of radioactive materials such as plutonium, americium and other actinides. It is an active component of manganese and zinc fertilizers used in agrochemical industry. It acts as a color inhibitor and is used in the production of acrylon. It is also used in soaps as a water softener.
Uses
Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers.
Uses
chelating agent, diagnostic aid
Production Methods
Pentetic acid is a pentaacetic acid triamine formed during the preparation of the amino carboxylic acid and its salt.
Definition
ChEBI: Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-).
General Description
Visit our Titration Center to learn more.
Pharmaceutical Applications
Pentetic acid is mainly used as a chelating agent in the preparation of imaging and contrast agents for radionuclide and magnetic resonance imaging.It is also used as a carrier excipient for neutron-capture isotopes in, for example, radiotherapy.Pentetic acid–isotope complexes have also been considered as model active substances in scintigraphic imaging studies.Pentetic acid has been used to chelate metal ions to reduce formation of reactive oxygen species during lyophilization.
Safety Profile
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.
Safety
Pentetic acid is used in intrathecal and intravenous injection
preparations. The pure form of pentetic acid is moderately toxic
by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg
storage
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Purification Methods
Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.]
Incompatibilities
The activity of pentetic acid as a chelating agent may cause unwanted effects in formulations containing metal ions. The desired chelate may be displaced by other ions from the formulation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (intrathecal and intravenous injections). Included in intravenous and intra-articular injections licensed in the UK.
Diethylenetriaminepentaacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Diethylenetriaminepentaacetic acid manufacturers
- Product
- Diethylenetriamine pentaacetic acid 67-43-6
- Price
- US $70.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-05-31
- Product
- Diethylenetriaminepentaacetic acid DTPA 67-43-6
- Price
- US $100.00/Kg/Drum
- Min. Order
- 1Kg/Bag
- Purity
- 99%min
- Supply Ability
- 200TON
- Release date
- 2020-12-21
- Product
- Diethylenetriaminepentaacetic acid 67-43-6
- Price
- US $10.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100 TON
- Release date
- 2020-12-29