WWL229
- Product Name
- WWL229
- CAS No.
- 1338575-28-2
- Chemical Name
- WWL229
- Synonyms
- WWL229;Reaxys ID: 25732135;WWL229, 10 mM in DMSO;XVBRVSAGMWRVCK-UHFFFAOYSA-N;WWL 229,WWL-229,Inhibitor,inhibit,WWL229;WWL229 4-Nitrophenyl 2-(3-methoxypropyl) piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 2-(3-methoxypropyl)-, 4-nitrophenyl ester
- CBNumber
- CB53067597
- Molecular Formula
- C16H22N2O5
- Formula Weight
- 322.36
- MOL File
- 1338575-28-2.mol
WWL229 Property
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- form
- oil
- color
- colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1180
- Product name
- WWL229
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $97.85
- Updated
- 2025/07/31
- Product number
- SML1180
- Product name
- WWL229
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $404
- Updated
- 2025/07/31
- Product number
- 16182
- Product name
- WWL229
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
- Product number
- 16182
- Product name
- WWL229
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16182
- Product name
- WWL229
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $193
- Updated
- 2024/03/01
WWL229 Chemical Properties,Usage,Production
Uses
WWL229 is a selective inhibitor of Ces3 (carboxylesterase-3) which mediates triglyceride hydrolysis in white adipose tissue. Potential anti-diabetic agent.
Biological Activity
WWL229 is a highly selective inhibitor of mouse Carboxylesterase 3 (Ces3) and human CES1 (orthologue of mCes3), serine hydrolases involved in lipolysis in addition to their activities as liver detoxification enzymes. WWL229 inhibits mCes3 with an IC50 of 10 μM, but not Ces1f, ABHD6 or other tested serine hydrolases. In a recent study, hCES1 activity was found to be increased two-fold in obese individuals and patients with type 2 diabetes compared to lean subjects, and is thought to generate surplus fatty acids th at can deposit ectopically in tissues. WWL229 inhibits adipocyte basal lipolysis and promotes differentiation and lipid storage in adipocytes.
WWL229 Preparation Products And Raw materials
Raw materials
Preparation Products
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