ChemicalBook > CAS DataBase List > 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine

2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine

Product Name
2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine
CAS No.
1346528-06-0
Chemical Name
2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine
Synonyms
ML241;ML241.HCl;ML241;ML 241;2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine;N-Benzyl-2-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine;4-Quinazolinamine, 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-
CBNumber
CB53119595
Molecular Formula
C23H24N4O
Formula Weight
372.46
MOL File
1346528-06-0.mol
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2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine Property

Boiling point:
600.3±65.0 °C(Predicted)
Density 
1.258±0.06 g/cm3(Predicted)
storage temp. 
-20°
solubility 
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 14 mg/ml with warming).
form 
solid
pka
7.08±0.20(Predicted)
color 
Pale yellow
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
B130102
Product name
2-(2H-Benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine
Packaging
2.5mg
Price
$45
Updated
2021/12/16
ApexBio Technology
Product number
B6107
Product name
ML241
Packaging
25mg
Price
$225
Updated
2021/12/16
DC Chemicals
Product number
DC9307
Product name
ML-241
Purity
>98%
Packaging
250mg
Price
$700
Updated
2021/12/16
Chemenu
Product number
CM208055
Product name
2-(2H-Benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine
Purity
97%
Packaging
250mg
Price
$842
Updated
2021/12/16
Alichem
Product number
1346528060
Product name
2-(2H-Benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine
Packaging
250mg
Price
$891
Updated
2021/12/16
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2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine Chemical Properties,Usage,Production

Description

ML241 (1346528-06-0) is a potent and selective p97 AAA ATPase inhibitor, IC50=100 nM. Inhibits degradation of a p97-dependent but not p97-independent proteasome substrate in a dual-reporter cell line.1?It impairs the endoplasmic reticulum-associated degradation (ERAD) pathway.1?ML241 and related inhibitors (DBeQ for example) have differential responses to p97 mutants as well as the presence of cofactors suggesting the possibility of context-dependent p97 inhibitors.2,3

Uses

2-(2H-Benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine is a p97 ATPase inhibitor.

in vitro

previous study showed that both ml241 and its analog ml240 were able to inhibit p97 atpase with ic(50) values of around 100 nm. both ml241 and ml240 could inhibit degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. in addition, both ml241 and ml240 could impair the endoplasmic-reticulum-associated degradation (erad) pathway. unexpectedly, ml240 could potently stimulate the accumulation of lc3-ii within minutes, inhibit cancer cell growth, and mobilize the executioner caspases 3 and 7 rapidly, whereas ml241 could not [1].

IC 50

100 nm

References

1) Chou?et al.?(2013),?Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase; Chem. Med. Chem.,?8?297 2) Chou?et al.?(2014)?Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains; J. Mol. Biol.?426?2886 3) Fang?et al. (2015)?Evaluating p97 inhibitor analogues for their domain selectivity and potency against the p97-p47 complex; Chem. Med. Chem.?10?52

2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine Suppliers

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1346528-06-0, 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amineRelated Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

  • 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine
  • ML241
  • ML241.HCl
  • ML241;ML 241
  • 4-Quinazolinamine, 2-(2,3-dihydro-4H-1,4-benzoxazin-4-yl)-5,6,7,8-tetrahydro-N-(phenylmethyl)-
  • N-Benzyl-2-(2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-5,6,7,8-tetrahydroquinazolin-4-amine
  • 1346528-06-0