6-ForMylindolo[3,2-b]carbazole

Product Name: 6-ForMylindolo[3,2-b]carbazole
CAS No.: 172922-91-7
Chemical Name: 6-ForMylindolo[3,2-b]carbazole
Synonyms: FICZ;6-FORMYLINDOLO A CARBAZOLE;6-FORMYLINDOLO [3,2-B] CARBAZOLE;6-Formylindolo[3,2-b]carbazole (FICZ);Indolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ;Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-
CBNumber: CB5312397
Molecular Formula: C19H12N2O
Formula Weight: 284.31
MOL File: 172922-91-7.mol

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6-ForMylindolo[3,2-b]carbazole Property

Boiling point:: 630.3±35.0 °C(Predicted)
Density: 1.463±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to 10 mg/ml).
form: powder
pka: 15.66±0.30(Predicted)
color: yellow to orange
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Safety

WGK Germany: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1489
Product name: FICZ
Purity: ≥95% (HPLC)
Packaging: 1MG
Price: $131
Updated: 2023/06/20

Sigma-Aldrich

Product number: SML1489
Product name: FICZ
Purity: ≥95% (HPLC)
Packaging: 5MG
Price: $530
Updated: 2023/06/20

Cayman Chemical

Product number: 19529
Product name: 6-Formylindolo[3,2-b]carbazole
Purity: ≥95%
Packaging: 500μg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 19529
Product name: 6-Formylindolo[3,2-b]carbazole
Purity: ≥95%
Packaging: 1mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 19529
Product name: 6-Formylindolo[3,2-b]carbazole
Purity: ≥95%
Packaging: 5mg
Price: $448
Updated: 2024/03/01

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6-ForMylindolo[3,2-b]carbazole Chemical Properties,Usage,Production

Description

6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd?= 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2

Uses

6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.

Biochem/physiol Actions

FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.

storage

Store at -20°C

References

1) Rannung?et al. (1987)?Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances; J. Biol. Chem.,?262?15422 .2) Wincent?et al. (2009)?The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b}carbazole is Present in Humans; J. Biol. Chem.,?284?2690

6-ForMylindolo[3,2-b]carbazole Preparation Products And Raw materials

Raw materials

Preparation Products

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6-ForMylindolo[3,2-b]carbazole Suppliers

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172922-91-7, 6-ForMylindolo[3,2-b]carbazoleRelated Search:

1-Aminobenzotriazole Omeprazole Ritonavir 5-Methoxy-alpha-methyltryptamine 3-Methylbenza[j]aceanthrene indolo(3,2-b)carbazole 6-ForMylindolo[3,2-b]carbazole

6-FORMYLINDOLO [3,2-B] CARBAZOLE

Indolo[3,2-b]carbazole-6-carbaldehyde

5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde

FICZ

5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde

5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde

6-FORMYLINDOLO A CARBAZOLE

Indolo[3,2-b]carbazole-6-carboxaldehyde, 5,11-dihydro-

6-Formylindolo[3,2-b]carbazole (FICZ)

inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ

172922-91-7

C19H10N2O