ChemicalBook > CAS DataBase List > M348

M348

Product Name
M348
CAS No.
899713-86-1
Chemical Name
M348
Synonyms
M348;ML348;CS-2370;GNF-Pf-1127;ML-348 (ML348);ML 348;GNF-PF-1127;alpha-synuclein 1-95, human;ML 348,Phospholipase,ML348,ML-348,inhibit,Inhibitor;N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide;1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-
CBNumber
CB53147505
Molecular Formula
C18H17ClF3N3O3
Formula Weight
415.79
MOL File
899713-86-1.mol
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M348 Property

Boiling point:
546.2±50.0 °C(Predicted)
Density 
1.422±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
form 
Powder
pka
13.13±0.70(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1901
Product name
ML348
Purity
≥98% (HPLC)
Packaging
5MG
Price
$105
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1901
Product name
ML348
Purity
≥98% (HPLC)
Packaging
25MG
Price
$424
Updated
2024/03/01
Cayman Chemical
Product number
18523
Product name
ML348
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
18523
Product name
ML348
Purity
≥98%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
18523
Product name
ML348
Purity
≥98%
Packaging
10mg
Price
$184
Updated
2024/03/01
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M348 Chemical Properties,Usage,Production

Uses

ML348 is a reversible LYPLA1 inhibitor. It is 14-fold selective for LYPLA1 over LYPLA2 and demonstrates little activity against a panel of more than 20 other serine hydrolases.

Biochem/physiol Actions

ML348 is a substrate-competitive, reversible and APT1-selective acyl-protein thioesterase (APT) inhibitor (IC50/Ki = 840 nM/300 nM against APT1; IC50 & Ki >10 μM against APT2). ML348 effectively inhibits cellular APT1 activity in cultures (by >95% in HEK293T & mouse T cells; 5 μM for 4 h) and in mice in vivo (by >90% in lung/heart/kidney and by ~50% in brain tissue 4 h post 50 mg/kg i.p. dosing) without affecting more than 15 cellular serine hydrolases and APT2.

storage

Store at +4°C

M348 Preparation Products And Raw materials

Raw materials

Preparation Products

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M348 Suppliers

China 73 India 1 United Kingdom 1 United States 11 USA 1 Global 87
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

899713-86-1, M348Related Search:

Nodinitib-1 9H-Purine-2-carbonitrile, 6-[(3,5-difluorophenyl)aMino]-9-ethyl- ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine PTP1B-IN-2 ML264 ML216 ML385 ML365 ML 141 ML355 ml390 (2,4,6-Trichloro-phenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML277

  • N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
  • CS-2370
  • M348
  • ML348
  • ML-348 (ML348)
  • GNF-Pf-1127
  • ML 348;GNF-PF-1127
  • 1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-
  • alpha-synuclein 1-95, human
  • ML 348,Phospholipase,ML348,ML-348,inhibit,Inhibitor
  • N-(2-Chloro-5-(trifluoromethyl)phenyl)-2-(4-(furan-2-carbonyl)piperazin-1-yl)acetamide
  • 899713-86-1