ML-180

ChemicalBook > CAS DataBase List > ML-180

Product Name: ML-180
CAS No.: 863588-32-3
Chemical Name: ML-180
Synonyms: ML-180;SR1848;ML-180 (SR1848);SR1848 >=98% (HPLC);6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2，4-dione;6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione;6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine- ,4(1H,3H)dione;6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione;6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione;2,4(1H,3H)-Pyrimidinedione, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-
CBNumber: CB53152684
Molecular Formula: C20H25ClN4O2
Formula Weight: 388.89
MOL File: 863588-32-3.mol

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ML-180 Property

Density: 1.312±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: 10 mg/ml
form: A crystalline solid
pka: 9.37±0.40(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 15181
Product name: ML-180
Purity: ≥98%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 15181
Product name: ML-180
Purity: ≥98%
Packaging: 5mg
Price: $108
Updated: 2024/03/01

Cayman Chemical

Product number: 15181
Product name: ML-180
Purity: ≥98%
Packaging: 10mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 15181
Product name: ML-180
Purity: ≥98%
Packaging: 25mg
Price: $345
Updated: 2024/03/01

AK Scientific

Product number: SYN5289
Product name: ML180
Packaging: 10mg
Price: $160
Updated: 2021/12/16

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ML-180 Chemical Properties,Usage,Production

Description

ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC₅₀ = 3.7 μM) with maximum efficacy of 64% repression. It is inactive at the related steroidogenic factor-1 transcriptional activator. Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC₅₀ = 2.05 μM).

Definition

ChEBI: 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is a member of piperazines.

ML-180 Preparation Products And Raw materials

Raw materials

Preparation Products

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863588-32-3, ML-180Related Search:

5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one ML-228 ML188 (Racemate) ML 18 ML-098 ML277 ML 204 ML329 ML364 VU0456810 ML188 ML418 [4-[Bis(4-chlorophenyl)methyl]piperazin-1-yl]-(5-methyl-4-nitro-1,2-oxazol-3-yl)methanone ML213 N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine ML-327 PTP1B-IN-2 ML264

SR1848

ML-180

6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione

2,4(1H,3H)-Pyrimidinedione, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-

6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione

SR1848 >=98% (HPLC)

ML-180 (SR1848)

6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexylpyrimidine- ,4(1H,3H)dione

6-[4-(3-Chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

ML-180,steroidogenic,SR-1848,Inhibitor,ML180,Orphan,factor-1,LRH-1,cancers,nuclear,NR5A2,NR5A1,ML 180,inhibit,homolog,liver,SR 1848,receptor,SF-1

6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2，4-dione

6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione

863588-32-3