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Dolutegravir Impurity 3

Product Name
Dolutegravir Impurity 3
CAS No.
1973402-05-9
Chemical Name
Dolutegravir Impurity 3
Synonyms
Dotiravir Impurity 3;Dolutegravir Impurity 3;Dolutegravir impurity A;Dolutegravir Impurity 51;DolutegravirImpurity9SodiumSalt;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p;(R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide;N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide;2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-;Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
CBNumber
CB53154305
Molecular Formula
C20H19F2N3O5
Formula Weight
419.38
MOL File
1973402-05-9.mol
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Dolutegravir Impurity 3 Property

Melting point:
95-100°C
Boiling point:
662.3±55.0 °C(Predicted)
Density 
1.51±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.50±1.00(Predicted)
color 
Yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D447205
Product name
N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
Packaging
2.5mg
Price
$215
Updated
2021/12/16
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Dolutegravir Impurity 3 Chemical Properties,Usage,Production

Uses

(R)-N-(2,4-Difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,3,4,8-tetrahydro-1H-pyrido[1,2-a]pyrazine-7-carboxamide is impurity E of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.

Dolutegravir Impurity 3 Preparation Products And Raw materials

Raw materials

Preparation Products

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Dolutegravir Impurity 3 Suppliers

China 25 India 3 United Kingdom 1 United States 1 Global 30
Pharmaffiliates Analytics and Synthetics P. Ltd
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Fax
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Email
mktg@pharmaffiliates.com
Country
India
ProdList
6739
Advantage
58
SynZeal Research Pvt Ltd
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standards@synzeal.com
Country
India
ProdList
6514
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1973402-05-9, Dolutegravir Impurity 3Related Search:

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  • Dolutegravir impurity 2/2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
  • 2H-Pyrido[1,2-a]pyrazine-7-carboxamide, N-[(2,4-difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-
  • Dolutegravir impurity A
  • Dolutegravir Impurity 3
  • N-[(2,4-Difluorophenyl)methyl]-1,8-dihydro-9-hydroxy-2-[(1R)-3-hydroxy-1-methylpropyl]-1,8-dioxo-2H-pyrido[1,2-a]pyrazine-7-carboxamide
  • Dolutegravir Impurity 51
  • (R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-2,8-dihydro-1H-pyrido[1,2-a]p
  • (R)-N-(2,4-difluorobenzyl)-9-hydroxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
  • DolutegravirImpurity9SodiumSalt
  • Dotiravir Impurity 3
  • 1973402-05-9