1,3-Adamantanedicarboxylic acid

Product Name: 1,3-Adamantanedicarboxylic acid
CAS No.: 39269-10-8
Chemical Name: 1,3-Adamantanedicarboxylic acid
Synonyms: ADAMANTANE-1,3-DICARBOXYLIC ACID;(1s,3s,5r,7r)-AdaMantane-1,3-dicarboxylic acid;AKOS BC-0656;1,3-DICARBOXYADAMANTANE;adamantane-1,3-dicarboxylate;1,3-ADAMANTANEDICARBOXYLIC ACID;1,3-Adamantanedicarboxylic Acid >1,3-Adamantanedicarboxylic acid 98%;Tricyclo[3.3.1.13,7]decane-1,3-dicarboxylic acid;tricyclo(3.3.1.1(sup3,7))decane-1,3-dicarboxylicacid
CBNumber: CB5316047
Molecular Formula: C12H16O4
Formula Weight: 224.25
MOL File: 39269-10-8.mol

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1,3-Adamantanedicarboxylic acid Property

Melting point:: 276-278 °C (lit.)
Boiling point:: 380.6±15.0 °C(Predicted)
Density: 1.461±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Sparingly), Methanol (Slightly, Heated)
form: Solid
pka: 4.24±0.40(Predicted)
color: White to Off-White
CAS DataBase Reference: 39269-10-8(CAS DataBase Reference)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36/37/39
WGK Germany: 3
RTECS: YD1994000
HS Code: 29172090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 340820
Product name: 1,3-Adamantanedicarboxylic acid
Purity: 98%
Packaging: 1G
Price: $120
Updated: 2023/01/07

TCI Chemical

Product number: A1358
Product name: 1,3-Adamantanedicarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $73
Updated: 2024/03/01

TCI Chemical

Product number: A1358
Product name: 1,3-Adamantanedicarboxylic Acid
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $246
Updated: 2024/03/01

Alfa Aesar

Product number: H60081
Product name: Adamantane-1,3-dicarboxylic acid, 98%
Packaging: 1g
Price: $53.65
Updated: 2024/03/01

Alfa Aesar

Product number: H60081
Product name: Adamantane-1,3-dicarboxylic acid, 98%
Packaging: 5g
Price: $211.65
Updated: 2024/03/01

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1,3-Adamantanedicarboxylic acid Chemical Properties,Usage,Production

Uses

1,3-Adamantanedicarboxylic acid is a carboxylic acid derivative of adamantane. It is widely used in drug industry, polymer synthesis and fine chemicals as key intermediates. It is also used as antidepressants or antiparkinsonic drugs in clinical practice.

Preparation

1,3-Adamantanedicarboxylic acid was synthesized from 1-adamantane carboxylic acid by one-pot method. In this process, the ratio of mixed acid (nitric acid and sulfuric acid) have important effect on the yield, the role of sulfuric acid not only is solvent, but also can improve the oxidate ability of nitric acid.
Efficient Synthesis of 1,3-Adamantanedicarboxylic Acid and 1,3-Diaminoadamantane

Reaction: 1-Adamantane carboxylic acid (20 g), nitric acid (65 %, 20 mL) and sulfuric acid (98 %, 160 mL) were placed in a three-necked roundbottom flask fitted with an efficient magnetic stirrer and a thermometer. Cooled to 0 oC and held at 0 oC, anhydrous formic acid (80 %, 70 mL) was added dropwise in 5 h and reacted for 1 h. poured to crushed ice, filtered and then washed the precipitate several times with water to give a white solid. Then the white solid was dissolved in aqueous NaOH solution and the upper clear solution was separated and acidified by HCl to pH = 3. Filtered, washed with water, dried in vacuum, recrystallized from ethanol. White solid, yield 22.9 g (92 %). m.p.: 275- 276 oC
1H NMR (DMSO-d6, 400 MHz) δ: 1.616 (m, 2H), 1.691-1.727 (m, 4H), 1.759-1.791 (m, 4H), 1.850-1.882 (m, 2H), 2.059 (m, 1H), 12.062 (br, s, 2H, COOH); 13C NMR (100 MHz, DMSO-d6) δ 27.37 (C-5, C-7), 34.98 (C-6), 37.66 (C-4, C-8, C-9, C-10), 39.78 (C-2), 39.89 (C-2, C-3), 177.76 (COOH). IR (KBr, νmax, cm-1) : 2913, 2851, 2636, 1691, 1451, 1410, 1344, 1249, 1103, 1084, 952, 743, 670, 528; Anal. calcd for C12H16O4: C 64.29, H 7.14; found C 64.55, H 7.22.

Purification Methods

Dissolve the acid in aqueous NaOH, treat with charcoal, filter and acidify with dilute HCl. It crystallises from MeOH. [Stetter & Wulff Chem Ber 93 1366 1960, Beilstein 9 III 4066, 9 IV 2997.]

1,3-Adamantanedicarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Adamantanedicarboxylic acid Suppliers

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View Lastest Price from 1,3-Adamantanedicarboxylic acid manufacturers

Shanghai Qyubiotech Co., Ltd.

Product: 1,3-Adamantanedicarboxylic acid 39269-10-8
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 97%+
Supply Ability: 10000kgs per Month
Release date: 2023-04-19

Career Henan Chemical Co

Product: 1,3-Adamantanedicarboxylic acid 39269-10-8
Price: US $1.00/kg
Min. Order: 1g
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-21

39269-10-8, 1,3-Adamantanedicarboxylic acidRelated Search:

1,3-Adamantanediol Adamantane Folic acid Altrenogest Amantadine OXALIC ACID Decane Ethyl 2-(Chlorosulfonyl)acetate Glycine Cyclohexanepropionic acid 1,3-adamantanedimethanol Azelaic acid Cyclooctanecarbaldehyde 2,2-Dimethylglutaric acid 1,3-Dimethyladamantane Dimethyl 1,3-adamantanedicarboxylate 1,3-Cyclohexanedicarboxylic acid CYCLOOCTANEMETHANOL

adamantane-1,3-dicarboxylate

tricyclo(3.3.1.1(sup3,7))decane-1,3-dicarboxylicacid

ADAMANTANE-1,3-DICARBOXYLIC ACID

AKOS BC-0656

1,3-ADAMANTANEDICARBOXYLIC ACID

1,3-DICARBOXYADAMANTANE

Tricyclo[3.3.1.13,7]decane-1,3-dicarboxylic acid

(1s,3s,5r,7r)-AdaMantane-1,3-dicarboxylic acid

1,3-AdaMantanedicarboxylic acid SynonyMs AdaMantane-1,3-dicarboxylic acid

1,3-Adamantanedicarboxylic acid 98%

1,3-Adamantanedicarboxylic Acid &gt

39269-10-8

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