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Glycidol

Product Name
Glycidol
CAS No.
556-52-5
Chemical Name
Glycidol
Synonyms
Oxiranemethanol;2,3-EPOXY-1-PROPANOL;GLYCEROLGLYCIDE;2,3-Epoxypropanol;oxiranyl-methanol;GLYCEROGLYCIDE;Glycidyl alcohol;OXYRANYL METHANOL;3-HYDROXY-1,2-EPOXYPROPANE;Levodropropizine EP Impurity C
CBNumber
CB5338946
Molecular Formula
C3H6O2
Formula Weight
74.08
MOL File
556-52-5.mol
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Glycidol Property

Melting point:
-54 °C
Boiling point:
61-62 °C/15 mmHg (lit.)
Density 
1.117 g/mL at 25 °C (lit.)
vapor density 
2.15 (vs air)
vapor pressure 
0.9 mm Hg ( 25 °C)
refractive index 
n20/D 1.433(lit.)
Flash point:
178 °F
storage temp. 
-20°C
solubility 
Soluble in acetone, alcohol, benzene, chloroform, and ether (Weast, 1986)
pka
14.62±0.10(Predicted)
form 
Powder, Crystals or Chunks
color 
White to light yellow-beige
Water Solubility 
soluble
Merck 
13,4503
BRN 
383562
Exposure limits
TLV-TWA 75 mg/m3 (25 ppm) (ACGIH); 150 mg/m3 (50 ppm) (OSHA); IDLH 500 ppm (NIOSH).
Stability:
Stability Stable, but may explode on contact with strong acids, strong bases, heavy metals, heavy metal salts. May decompose on exposure to water or moist air.
InChIKey
CTKINSOISVBQLD-UHFFFAOYSA-N
LogP
-0.95 at 25℃
CAS DataBase Reference
556-52-5(CAS DataBase Reference)
NIST Chemistry Reference
Glycidol(556-52-5)
IARC
2A (Vol. 77) 2000
EPA Substance Registry System
Glycidol (556-52-5)
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Safety

Hazard Codes 
T
Risk Statements 
45-60-21/22-23-36/37/38-68
Safety Statements 
53-45-36/37-26
RIDADR 
UN 2810 6.1/PG 3
OEB
A
OEL
TWA: 25 ppm (75 mg/m3)
WGK Germany 
3
RTECS 
UB4375000
10-21
Autoignition Temperature
780 °F
Hazard Note 
Toxic
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29109000
Hazardous Substances Data
556-52-5(Hazardous Substances Data)
Toxicity
Acute oral LD50 for mice 431 mg/kg, rats 420 mg/kg (quoted, RTECS, 1985).
IDLA
150 ppm
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H330Fatal if inhaled

H335May cause respiratory irritation

H341Suspected of causing genetic defects

H350May cause cancer

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G5809
Product name
Glycidol
Purity
96%
Packaging
2.5kg
Price
$760
Updated
2024/03/01
Sigma-Aldrich
Product number
74595
Product name
(±)-Glycidol
Purity
analytical standard
Packaging
100mg
Price
$72.7
Updated
2024/03/01
Sigma-Aldrich
Product number
G5809
Product name
Glycidol
Purity
96%
Packaging
5g
Price
$45
Updated
2024/03/01
Sigma-Aldrich
Product number
G5809
Product name
Glycidol
Purity
96%
Packaging
100g
Price
$64.9
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001048
Product name
Levodropropizine impurity C
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001048
Price
$153
Updated
2024/03/01
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Glycidol Chemical Properties,Usage,Production

Description

Glycidol is a chiral molecule with epoxide and primary alcohol functional groups. It is racemic mixture and exists in the dextrorotatory and the levorotatory enantiomeric forms. Several synthetic methods are available for preparation of glycidol. However, it is commercially prepared from the epoxidation of allyl alcohol with hydrogen peroxide and a catalyst (tungsten or vanadium), or from the reaction of epichlorohydrin with caustic. Glycidol has been used in the industrial synthesis of pharmaceutical products since the 1970s. However, its use for research purposes has been reported since 1956. Available information indicates that glycidol is manufactured by several companies in Japan, Germany, and the United States.

Chemical Properties

colourless liquid

Chemical Properties

Glycidol is a colorless liquid.

Uses

Glycidol is used as a stabilizer for natural oilsand vinyl polymers, as a demulsifier, and asa leveling agent for dyes.

Uses

Stabilizer in manufacturing of vinyl polymers; intermediate in synthesis of glycerol, glycidyl ethers, and amines; additive for oil and synthetic hydraulic fluids; epoxy resin diluent.

Uses

Glycidol is a Stabilizer in the manufacture of vinyl polymers; chemical intermediate in preparation of glycerol, glycidyl ethers, esters, and amines; in pharmaceuticals; in sanitary chemicals.

Definition

an epoxide

General Description

Odorless clear colorless liquid.

Air & Water Reactions

Sensitive to moisture.

Reactivity Profile

Glycidol is sensitive to moisture. Glycidol is also sensitive to light. Glycidol may polymerize if heated above room temperature. Glycidol may darken on storage. Stability studies of Glycidol stored for two week protected from light indicated definite decomposition at 140° F, and strongly indicated instability at 77° F. A solution of Glycidol in water was found to be unstable when stored at room temperature, even after one day in the dark. Glycidol is incompatible with strong oxidizers. Glycidol will undergo explosive decomposition in the presence of strong acids or bases, salts (such as aluminum chloride, iron(III)chloride or tin(IV) chloride) or metals (such as copper and zinc). Glycidol is also incompatible with nitrates. Glycidol will attack some forms of plastics, rubber and coatings.

Hazard

Toxic material. Probable carcinogen.

Health Hazard

Glycidol is an eye, lung, and skin irri-tant. The pure compound caused severebut reversible corneal injury in rabbit eyes(ACGIH 1986). Exposure to its vapor causedirritation of lung in mice, resulting in pneu-monitis. There is no evidence of any cumula-tive toxicity. From the limited toxicity data,it appears that the health hazard to humansfrom its exposure is, primarily, respiratoryirritation, stimulation of the central nervoussystem, and depression.
Glycidol is mutagenic, testing positive inthe histidine reversion–Ames test. There isno report of its carcinogenic action. Oraland intraperitoneal administration of gly-cidol in rats showed harmful effects onfertility.

Fire Hazard

Glycidol is combustible.

Flammability and Explosibility

Non flammable

Safety Profile

Confirmed carcinogen with carcinogenic data reported. Poison by intraperitoneal route. Moderately toxic by ingestion, inhalation, and sh contact. Experimental teratogenic and reproductive effects. A skin irritant. Human mutation data reported. Animal experiments suggest somewhat lower toxicity than for related epoxy compounds. Readdy absorbed through the skin. Causes nervous excitation followed by depression. Explodes when heated or in the presence of strong acids,bases, metals (e.g., copper, zinc), and metal salts (e.g., aluminum chloride, iron(II1) chloride, tin(Iy chloride). When heated to decomposition it emits acrid smoke and fumes. See also DIGLYCIDYL ETHER.

Synthesis

A method for directly preparing glycidol from glycerol is shown as following steps: putting a mixed solvent in a glass or enamel reaction kettle, adding glycerol to the mixed solvent, controlling the concentration of glycerol in the reaction liquid within the range of 0.5-3.0 mol/L, then adding a catalyst, and controlling the quantity of the catalyst to account for 0.01-0.20 of the weight of the glycerol; increasing the temperature of the mixed reaction liquid to the range of 40-100 ℃ under stirring condition and reacting at a constant temperature for 2-20 hours; and after reaction, filtering off the catalyst from the reaction liquid, then distilling the mixed reaction liquid, and collecting the fraction in the range of 160-161 ℃, thereby obtaining the product 2,3-glycidol.

Potential Exposure

Glycidol is used as an intermediate in the synthesis of glycerol, glycidyl ethers, esters, and amines.

Carcinogenicity

Glycidol is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.

Environmental Fate

Chemical/Physical. May hydrolyze in water forming glycerin (Lyman et al., 1982).

Shipping

UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Purification Methods

[S(-)-isomer, § also available on polymer support, has b 49-50o/7mm, 66-67o/19mm, [ ] D -1 5o(neat)], [R(+)-isomer has b 56 -5 6 . 5o/11mm, d 4 1.117, n D 1.429, [ ] D +15o (neat)]. Purify glycidol by fractional distillation.

Toxicity evaluation

Glycidol is a small molecule possessing a chemically reactive epoxide group. Therefore, it acts as a direct alkylating agent. Nucleophilic bioactive compounds such as glutathione react readily with glycidol. Glycidol decreases glutathione content in rat liver by direct binding to the glutathione. In vitro experiments revealed that glycidol reacts with purified DNA to form the DNA adducts. This is likely to be responsible for the genotoxic activity of the compound without a requirement for metabolic activation.

Incompatibilities

May form explosive mixture with air. Violent reaction with strong oxidizers, nitrates. Decomposes on contact (especially in the presence of heat) with strong acids, strong bases, water, metal salts, e.g., alu minum chloride, ferric chloride, and tin chloride), or metals (copper and zinc), causing fire and explosion hazard. Contact with barium, lithium, sodium, magnesium, and tita nium may cause polymerization. Attacks some plastics, rubber, and coatings.

Waste Disposal

Concentrated waste contain ing no peroxides: discharge liquid at a controlled rate near a pilot flame. Concentrated waste containing peroxides: perforation of a container of the waste from a safe distance followed by open burning.

Glycidol Preparation Products And Raw materials

Raw materials

Preparation Products

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Glycidol Suppliers

CHANGZHOU HONGYU CHEMICAL CO.,LTD
Tel
0519-89996110 13813691203
Email
1031106541@qq.com
Country
China
ProdList
183
Advantage
58
Changzhou Huaren Chemical Co., Ltd
Tel
0519-88103998 13646148298
Fax
0519-88104456
Email
amy.zhou@huarenchem.com
Country
China
ProdList
56
Advantage
63
Guangdong Qianjin Chemical Reagent Co., Ltd.
Tel
0751-2818792 13435114148
Email
3128240096@qq.com
Country
China
ProdList
2992
Advantage
58
Changzhou Run-chem Biotech Co., ltd
Tel
15061933924
Email
3301839366@qq.com
Country
China
ProdList
813
Advantage
58
Zhongshan Dixin Chemical Co., Ltd
Tel
18620540041 18620540041
Email
1670385794@qq.com
Country
China
ProdList
793
Advantage
58
Shanghai Likas Industrial Co., LTD
Tel
19821976800
Email
chinalikas@163.com
Country
China
ProdList
438
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8415
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44689
Advantage
61
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View Lastest Price from Glycidol manufacturers

HebeiShuoshengImportandExportco.,Ltd
Product
Glycidol 556-52-5
Price
US $6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
2000KG/Month
Release date
2024-08-09
Hebei Longbang Technology Co., Ltd
Product
Glycidol 556-52-5
Price
US $5.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20TONS
Release date
2024-05-13
Hebei Yanxi Chemical Co., Ltd.
Product
Glycidol 556-52-5
Price
US $60.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-22

556-52-5, GlycidolRelated Search:


  • GLYCEROLGLYCIDE
  • (+/-)-GLYCIDOL
  • GLYCIDOL
  • GLYCEROGLYCIDE
  • 3-HYDROXY-1,2-EPOXYPROPANE
  • 3-HYDROXYPROPYLENE OXIDE
  • 2,3-EPOXY-1-PROPANOL
  • 2,3-EPOXYPROPAN-1-OL
  • 2,3-EPOXYPROPANOL-1
  • OXYRANYL METHANOL
  • (+/-)-OXIRANE-2-METHANOL
  • (±)-Oxiranyl-methanol
  • 2-hydroxymethyloxiran
  • 2-Oxiranylmethanol
  • (RS)-Glycidol
  • ±-Oxiranyl-methanol
  • 1,2-Epoxy-3-hydroxypropane
  • 1-Hydroxy-2,3-epoxypropane
  • 1-Propanol, 2,3-epoxy-
  • 1-Propanol,2,3-epoxy-
  • 2-(Hydroxymethyl)oxirane
  • 2,3-epoxy-1-propano
  • 2,3-Epoxypropanol
  • 2,3-Epoxyproqanol
  • rac-(R*)-Oxirane-2-methanol
  • rac-Oxirane-2α*-methanol
  • Glycidol ,97%
  • 3-Hydroxy-1,2-propenoxide
  • lycidol
  • Glycidol, 2,3-Epoxypropan-1-ol, 2-(Hydroxymethyl)oxirane, Epihydrin alcohol
  • Glycidol, 96% 100ML
  • Glycidol, 96% 500ML
  • 3-Hydroxy-1,2-Propenoxide/Glycidol
  • [3-(hydroxyMethyl)oxiran-2-yl](oxiran-2-yl)Methanol
  • Glycidol 96%
  • Glycidol, 2,3-Epoxypropan-1-ol, Epihydrin alcohol, 3-Hydroxy-1,2-propenoxide
  • Metoprolol Impurity 24
  • Levodropropizine ImpurityⅢ:glycidol
  • Levodropropizine EP Impurity C
  • 3-Hydroxypropenoxid
  • Allyl alcohol oxide
  • allylalcoholoxide
  • dl-Glycidol
  • Epihydrin alcohol
  • epihydrinalcohol
  • EpiolOH
  • Epoxypropyl alcohol
  • epoxypropylalcohol
  • Glyceringlycid
  • Glycide
  • Glycidyl alcohol
  • glycidylalcohol
  • Hydroxymethyl ethylene oxide
  • hydroxymethylethyleneoxide
  • Hydroxymethyloxiran
  • Hydroxymethyloxirane
  • Methanol, oxiranyl-
  • Monoepoxide glycidol