ChemicalBook > CAS DataBase List > Prednicarbate

Prednicarbate

Product Name: Prednicarbate
CAS No.: 73771-04-7
Chemical Name: Prednicarbate
Synonyms: Regemt;Regenit;HOE-777;Dermatop;Prednitop;S-77-0777;PREDNICARBATE;UNII-V901LV1K7D;Prednicarbate CRS;Prednicarbate, >=98%
CBNumber: CB5342987
Molecular Formula: C27H36O8
Formula Weight: 488.57
MOL File: 73771-04-7.mol

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Prednicarbate Property

Melting point:: 110-112°; mp 183°
alpha: D20 +63° (c = 0.1 in ethanol)
Boiling point:: 640.7±55.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Practically insoluble in water, freely soluble in acetone and in ethanol (96 per cent), sparingly soluble in propylene glycol. It shows polymorphism (5.9).
pka: 14.05±0.70(Predicted)
form: Solid
color: White to Off-White
InChIKey: FNPXMHRZILFCKX-IVRISGIPNA-N
SMILES: [C@@]1(OC(=O)OCC)(C(=O)COC(=O)CC)CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C |&1:0,17,19,29,31,33,36,r|

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Safety

HS Code: 2937290000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002231
Product name: Prednicarbate for peak identification
Purity: CRS, European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $165
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0001630
Product name: Prednicarbate for system suitability A
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 10 mg
Price: $236
Updated: 2025/07/31

Sigma-Aldrich

Product number: PHR3101
Product name: Prednicarbate
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 500MG
Price: $190
Updated: 2025/07/31

Sigma-Aldrich

Product number: P2698000
Product name: Prednicarbate
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 110 mg
Price: $156
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1554909
Product name: Prednicarbate
Packaging: 200mg
Price: $357
Updated: 2025/07/31

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Prednicarbate Chemical Properties,Usage,Production

Description

Prednicarbate is a potent topical antiinflammatory agent with minimal systemic effects. It is useful in the treatment of cutaneous inflammatory disorders such as eczema and psoriasis.

Description

Prednicarbate is a synthetic corticosteroid and a derivative of prednisolone . It has anti-inflammatory activity comparable to that of desoximetasone in various murine models when administered topically but lacks activity when administered subcutaneously. Topical administration of prednicarbate (2 drops of a 0.1% solution per day) induces wound healing in hairless mice. Formulations containing prednicarbate have been used to treat chronic hand eczema.

Chemical Properties

White or almost white, crystalline powder.

Originator

Hoechst AG (W. Germany)

Uses

Topical anti-inflammatory agent. Glucocorticoid.
Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.

Indications

Prednicarbate (Dermatop E) is a synthetic nonfluorinated topical corticosteroid.

Definition

ChEBI: Prednicarbate is a corticosteroid hormone.

brand name

Dermatop (Sanofi Aventis).

General Description

Prednicarbate, 17-[(ethoxycarbonyl)oxy]-11β-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione, is a prednisolone derivative with a C21 propionateester and a C17 ethyl carbonate group. It is availablefor use only in a 0.1% topical cream. Prednicarbate is amedium-potency GC.

References

[1] H G ALPERMANN H G V J Sandow. [Animal experiment studies on the topical and systemic effectiveness of prednisolone-17-ethylcarbonate-21-propionate].[J]. Zeitschrift fur Hautkrankheiten, 1986, 61 Suppl 1: 7-17.
[2] NICHOLAS S. BODOR Laszlo B Susan Tatar Kiss Buns. Novel soft steroids: effects on cell growth in vitro and on wound healing in the mouse[J]. Steroids, 1991, 56 8: Pages 434-439. DOI: 10.1016/0039-128x(91)90032-q
[3] STEPHANIE SOOST. Topical therapy of hand eczema – analysis of the prescription profile from dermatologists in private practice[J]. Journal Der Deutschen Dermatologischen Gesellschaft, 2011, 10 3: 180-184. DOI: 10.1111/j.1610-0387.2011.07787.x

Prednicarbate Preparation Products And Raw materials

Raw materials

Silica gel Acetic anhydride Propionyl chloride Prednisolone Tetraethyl orthocarbonate PARA TOLUENE Sodium bicarbonate Anhydrous pyridine

Preparation Products

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View Lastest Price from Prednicarbate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Prednicarbate 73771-04-7
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 97%-102%; EPV
Supply Ability: 50kgs
Release date: 2021-08-11

Career Henan Chemical Co

Product: Prednicarbate 73771-04-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-07-09

73771-04-7, PrednicarbateRelated Search:

3-(4-Phenoxy-phenyl)-1-piperidin-3-yl-1H-pyrazolo[3,4-d]pyriMidin-4-ylaMine Clindamycin 4-Phosphate Ambroxol hydrochloride N-Deformyl-N-pivaloyl Orlistat 10-Propargyl-10-deazaaminopterin Cilastatin Esmolol Impurity 2 HCl (R)-1-[3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]ethanone AMbroxol EP IMpurity D GATIFLOXACIN RELATED COMPOUND A Eflone Prednisolone-21-acetate Prednicarbate Prednicarbate Related Compound A Prednicarbate Related Compound C Prednicarbate Related Compound B Prednisolone prednisolone 17-ethylcarbonate

PREDNICARBATE

11β，17，21-Trihydroxypregna-1，4-diene-3，20-dione 17-(ethylcarbonate)-21-propionate

[2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate

Dermatop

HOE-777

Prednitop

Regemt

S-77-0777

Prednisolone 17-(ethyl carbonate) 21-propionate

Pregna-1,4-diene-3,20-dione, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)-, (11b)-

Regenit

17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-21-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione

17-[(Ethoxycarbonyl)oxy]-11β-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione

Prednicarbate (200 mg)

(11β)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)pregna-1,4-diene-3,20-dione

Prednicarbate, >=98%

Prednicarbate for system suitability A

Prednicarbate for system suitability

Prednicarbate CRS

Prednicarbate for system suitability A CRS

Pregna-1,4-diene-3,20-dione, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-21-(1-oxopropoxy)-, (11β)-

2-((8S,9S,10R,11S,13S,14S,17R)-17-((ethoxycarbonyl)oxy)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl propionate

Prednicarbate (1554909)

Dermatop E emollient

UNII-V901LV1K7D

C16286450 Prednicarbate

2-(17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethyl] propanoate

73771-04-7

C27H36O8

Intermediates & Fine Chemicals

Pharmaceuticals

Steroids