1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
- Product Name
- 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
- CAS No.
- 614730-97-1
- Chemical Name
- 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE
- Synonyms
- tert-butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate;1-Boc-4-fluoro-4-(hydroxy...;1-BOC-4-FLUORO-4 (HYDROXYMETHYL);1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE;tert-Butyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;tert-Butyl 4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate 97%;1,1-Dimethylethyl 4-fluoro-4-(hydroxymethyl)-1-piperidinecarboxylate;4-fluoro-4-hydroxymethyl-piperidine-1-carboxylic acid tert-butyl ester;1-PIPERIDINECARBOXYLIC ACID, 4-FLUORO-4-(HYDROXYMETHYL)-, 1,1-DIMETHYLETHYL ESTER
- CBNumber
- CB5347225
- Molecular Formula
- C11H20FNO3
- Formula Weight
- 233.28
- MOL File
- 614730-97-1.mol
1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Property
- Boiling point:
- 311.0±27.0 °C(Predicted)
- Density
- 1.13±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.94±0.10(Predicted)
- Appearance
- Colorless to off-white Solid-Liquid Mixture
- InChI
- InChI=1S/C11H20FNO3/c1-10(2,3)16-9(15)13-6-4-11(12,8-14)5-7-13/h14H,4-8H2,1-3H3
- InChIKey
- BWZOULIMVKCGII-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCC(F)(CO)CC1
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B809640
- Product name
- tert-Butyl4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- PC430313
- Product name
- tert-Butyl4-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate
- Purity
- 97%
- Packaging
- 250mg
- Price
- $76
- Updated
- 2021/12/16
- Product number
- 096940
- Product name
- 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-W000442
- Product name
- 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
- Packaging
- 1g
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 096940
- Product name
- 1-Boc-4-Fluoro-4-(hydroxymethyl)piperidine
- Purity
- 95+%
- Packaging
- 500mg
- Price
- $116
- Updated
- 2021/12/16
1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Chemical Properties,Usage,Production
Uses
tert-Butyl 4-Fluoro-4-(hydroxymethyl)piperidine-1-carboxylate is used in preparation of heterocyclic compounds as BCL 2 inhibitors.
Synthesis
147804-30-6
614730-97-1
General procedure for the synthesis of 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine from 1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester: Commercially available epoxide (2 g, 9.38 mmol) was dissolved in 10 mL of dichloromethane, and added slowly and dropwise to a pre-cooled to -10°C 0.6 mL solution of HF pyridinium fluoride (70%) in a 10 mL dichloromethane to a mixture of 0.6 mL HF pyridinium fluoride (70%) and 10 mL methylene chloride. The reaction mixture was kept at -10°C. After the dropwise addition was completed, the reaction system was warmed to room temperature and stirred continuously for 4 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and subsequently washed with saturated aqueous sodium carbonate solution. The organic phase was separated, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to remove the solvent to give the crude product. Purification by silica gel column chromatography with ethyl acetate/heptane (20% to 50%) as eluent afforded 1-Boc-4-fluoro-4-(hydroxymethyl)piperidine as a pale yellow oil (1.44 g, 66% yield).1H-NMR (400 MHz, CDCl3) data: δ=1.44 (s, 9H), 1.47-1.63 (m, 2H). 1.85 (m, 2H), 3.08 (m, 2H), 3.56 (s, 1H), 3.61 (s, 1H), 3.92 (brs, 2H). ms ESI: m/z=233.98 (M+).
References
[1] Patent: US2011/256064, 2011, A1. Location in patent: Page/Page column 19; 20
[2] Patent: EP2377860, 2011, A1. Location in patent: Page/Page column 26
[3] Patent: EP1505067, 2005, A1. Location in patent: Page/Page column 368; 369
[4] Journal of Medicinal Chemistry, 2008, vol. 51, # 13, p. 3692 - 3695
[5] Patent: WO2004/5255, 2004, A1. Location in patent: Page 26-27
1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- Fax
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- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88
View Lastest Price from 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE manufacturers
- Product
- 1-BOC-4-FLUORO-4-(HYDROXYMETHYL)-PIPERIDINE 614730-97-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-26