ChemicalBook > CAS DataBase List > BOC-GLU(OME)-OH

BOC-GLU(OME)-OH

Product Name: BOC-GLU(OME)-OH
CAS No.: 45214-91-3
Chemical Name: BOC-GLU(OME)-OH
Synonyms: N-Boc-L-glutamic acid-5-methylester;Boc-L-Glu(OMe)-OH;BOC-GLU(OME)-OH;t-Boc-L-Glu(OMe)-OH;BOC-GLU(OME)-OH USP/EP/BP;45214-91-3 BOC-GLU(OME)-OH;N-Boc-L-glutamic acid 5-methyl;BOC-L-glutamate-5-methyl ester;Boc-Glu(OMe)-OH Boc-Glu(OMe)-OH;(Tert-Butoxy)Carbonyl Glu(OMe)-OH
CBNumber: CB5353240
Molecular Formula: C11H19NO6
Formula Weight: 261.27
MOL File: 45214-91-3.mol

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BOC-GLU(OME)-OH Property

Melting point:: 74-77 °C
Boiling point:: 428.4±40.0 °C(Predicted)
Density: 1.182±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), Methanol (Slightly)
form: Solid
pka: 3.82±0.10(Predicted)
color: White
InChI: InChI=1S/C11H19NO6/c1-11(2,3)18-10(16)12-7(9(14)15)5-6-8(13)17-4/h7H,5-6H2,1-4H3,(H,12,16)(H,14,15)/t7-/m0/s1
InChIKey: OHYMUFVCRVPMEY-ZETCQYMHSA-N
SMILES: C(O)(=O)[C@H](CCC(OC)=O)NC(OC(C)(C)C)=O

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Safety

HS Code: 2924190090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P285In case of inadequate ventilation wear respiratory protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B656085
Product name: N-Boc-L-glutamicAcid5-MethylEster
Packaging: 10g
Price: $150
Updated: 2021/12/16

Usbiological

Product number: 264436
Product name: Boc-L-glutamic acid gamma-methyl ester
Packaging: 500mg
Price: $375
Updated: 2021/12/16

AK Scientific

Product number: J94997
Product name: Boc-L-Glutamicacidgamma-methylester
Packaging: 5g
Price: $10
Updated: 2021/12/16

Activate Scientific

Product number: AS91156
Product name: N-Boc-L-glutamic Acid 5-Methyl Ester
Purity: 97+% ee
Packaging: 5G
Price: $12
Updated: 2021/12/16

AK Scientific

Product number: X4229
Product name: Boc-L-Glutamicacidgamma-methylester
Packaging: 5g
Price: $14
Updated: 2021/12/16

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BOC-GLU(OME)-OH Chemical Properties,Usage,Production

Chemical Properties

Boc-L-glutamic acid-5-methyl ester is an amino acid derivative, the molecule contains both acidic and basic groups, therefore, the amino acid can react with stronger acids as well as stronger bases to produce stable salts, with the characteristics of amphoteric compounds, which are mainly used for the preparation of compound amino acid infusion in medicine, and also used for the synthesis of peptide drugs.

Uses

N-Boc-L-glutamic Acid 5-Methyl Ester is an intermediate used in the synthesis of Isodesmosine Chloride Hydrate (Synthetic) (I815051), which is a component of elastin and also it is extremely hygroscopic and must be stored over a desiccant such as silica gel.

Synthesis

1499-55-4

24424-99-5

45214-91-3

In a round-bottomed flask, triethylamine (188 g, 1.86 mol, 1.0 eq.) was slowly added dropwise to a stirred mixed solution containing di-tert-butyl dicarbonate (162 g, 0.744 mol, 1.2 eq.) and L-glutamic acid-5-methyl ester (100 g, 0.62 mol, 1.0 eq.) in a solvent consisting of a mixture of water (500 mL) and 1,4-dioxane (500 mL) in a solvent mixture of water (500 mL) and 1,4-dioxane (500 mL). The reaction mixture was stirred continuously for 18 hours at room temperature. Upon completion of the reaction, the reaction solution was extracted with methyl tert-butyl ether (MTBE, 500 mL x 2). The aqueous phase was cooled in an ice bath and the pH was carefully adjusted to 3 by slowly adding 10% citric acid solution.Subsequently, the carbamate product in the aqueous phase was extracted with ethyl acetate (500 mL × 2). The organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford (S)-2-((tert-butoxycarbonyl)amino)-5-methoxy-5-oxopentanoic acid (Compound A4-2) as a clear viscous oil (180 g, 100% yield). Mass spectrometry (MS-ESI) analysis showed [M + 1]+ m/z 262.1.

References

[1] Patent: WO2018/67422, 2018, A1. Location in patent: Page/Page column 47
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 13, p. 3793 - 3797
[3] Patent: US2010/184805, 2010, A1. Location in patent: Page/Page column 33-34
[4] Chemical Communications, 2001, # 8, p. 717 - 718
[5] Patent: US2016/16890, 2016, A1. Location in patent: Paragraph 0165-0166

BOC-GLU(OME)-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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BOC-GLU(OME)-OH Suppliers

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View Lastest Price from BOC-GLU(OME)-OH manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Boc-Glu(OMe)-OH 45214-91-3
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min
Supply Ability: 1000kg
Release date: 2021-08-28

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Boc-L-Glu(OMe)-OH 45214-91-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2023-09-21

PNP Biotech Co. Ltd

Product: BOC-GLU(OME)-OH 45214-91-3
Price: US $0.00/KG
Min. Order: 25KG
Purity: 98%
Supply Ability: Inquiry
Release date: 2022-11-25

45214-91-3, BOC-GLU(OME)-OHRelated Search:

BOC-MET-ONP N-(tert-Butoxycarbonyl)-L-phenylalanine Boc-L-Pyroglutamic acid methyl ester Boc-L-glutamic acid γ-allyl ester BOC-GLU(OME)-OH Boc-L-glutamic acid 5-cyclohexyl ester BOC-GLU(OME)-OH DCHA,Boc-Glu(OMe)-OH&#8226 N-tert-Butoxycarbonyl-L-glutamic acid gamma-tert-butyl ester Boc-L-Glutamic acid 5-benzylester L-Glutamic acid 5-methyl ester Boc-L-Glutamic acid BOC-GLU(OFM)-OH BOC-GLU(OME)-ONP BOC-GLU(OBZL)-OH DCHA BOC-N-ME-GLU(OBZL)-OH BOC-L-GLUTAMIC ACID DIBENZYL ESTER BOC-GLU(OAL)-OAL BOC-GLU(OBZL)-OME

BOC-GLU(OME)-OH

BOC-L-GLUTAMIC ACID GAMMA-METHYL ESTER

N-ALPHA-T-BUTOXYCARBONYL-L-GLUTAMIC ACID GAMMA-METHYL ESTER

BOC-L-GLUTAMIC ACID Y-METHYLESTER

N-ALPHA-BOC-L-GLUTAMIC ACID GAMMA-METHYL ESTER

N-Boc-L-glutamic acid-5-methylester

(S)-2-(tert-butoxycarbonylamino)-5-methoxy-5-oxopentanoic acid

Boc-Glu(OMe)-OH Boc-L-glutaMic acid γ-Methyl ester

L-GlutaMic acid,N-[(1,1-diMethylethoxy)carbonyl]-, 5-Methyl ester

Boc-L-Glu(OMe)-OH

(Tert-Butoxy)Carbonyl Glu(OMe)-OH

N-Boc-L-glutamicacid5-methylester,95%

(2S)-5-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoicaci

Boc-Glu(OMe)-OH Boc-Glu(OMe)-OH

BOC-GLU(OME)-OH USP/EP/BP

N-α-(t-Butoxycarbonyl)-L-glutamic acid γ-methyl ester

(2S)-5-methoxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid

Tert butoxycarbonyl-glutamine-5-methyl ester

45214-91-3 BOC-GLU(OME)-OH

N-Boc-L-glutamic acid 5-methyl

5-Methyl hydrogen N-[(1,1-dimethylethoxy)carbonyl]-L-glutamate

N-tert butoxycarbonyl-L-glutamate 5-methyl ester

BOC-L-glutamate-5-methyl ester

t-Boc-L-Glu(OMe)-OH

5-Methyl hydrogen N-N-BOC-L-glutamate

45214-91-3