3-Morpholinosydnonimine hydrochloride
- Product Name
- 3-Morpholinosydnonimine hydrochloride
- CAS No.
- 16142-27-1
- Chemical Name
- 3-Morpholinosydnonimine hydrochloride
- Synonyms
- SIN-1;SIN-1 HCL;LINSIDOMINE;SIN-1 CHLORIDE;LINSIDOMINE HCL;SIN-I HYDROCHLORIDE;SIN-1 HYDROCHLORIDE;MolsidoMine IMpurity A;Linsidomine (chloride);Molsidomine Impurity 7
- CBNumber
- CB5370997
- Molecular Formula
- C6H11ClN4O2
- Formula Weight
- 206.63
- MOL File
- 16142-27-1.mol
3-Morpholinosydnonimine hydrochloride Property
- Melting point:
- 186 °C
- Density
- 1.303 at 20℃
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
- form
- White solid
- color
- White
- Water Solubility
- soluble
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored.
- LogP
- -6.28 at 25℃
- CAS DataBase Reference
- 16142-27-1(CAS DataBase Reference)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- WU7687800
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M5793
- Product name
- 3-Morpholinosydnonimine hydrochloride
- Purity
- (consistent with structure, NMR)
- Packaging
- 25mg
- Price
- $234
- Updated
- 2025/07/31
- Product number
- 567028
- Product name
- SIN-1, Hydrochloride
- Purity
- Nitric oxide (NO) donor.
- Packaging
- 20mg
- Price
- $159
- Updated
- 2025/07/31
- Product number
- 82220
- Product name
- SIN-1 (chloride)
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- M5793
- Product name
- 3-Morpholinosydnonimine hydrochloride
- Purity
- (consistent with structure, NMR)
- Packaging
- 100mg
- Price
- $781
- Updated
- 2025/07/31
- Product number
- 82220
- Product name
- SIN-1 (chloride)
- Purity
- ≥99%
- Packaging
- 50mg
- Price
- $131
- Updated
- 2024/03/01
3-Morpholinosydnonimine hydrochloride Chemical Properties,Usage,Production
Description
As the active metabolite of molsidomine, SIN-
Chemical Properties
White Crystalline Solid
Uses
SIN-1 is a metabolite of the vasodilator molsidomine and is considered to be a peroxynitrite releasing compound
Uses
3-Morpholinosydnonimine hydrochloride has been used:
- as a peroxynitrite donor standard to study the accumulation of peroxynitrite?in?Arabidopsis thaliana
- to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells
- as a ROS to study its effects on mouse embryonic fibroblasts
Uses
3-Morpholinosydnonimine hydrochloride is a metabolite of the vasodilator Molsidomine (M488002) and is considered to be a peroxynitrite releasing compound. Molsidomine Impurity A.
Indications
Linsidomine (SIN-1) is an active metabolite of the antianginal drug molsidomine. Its mechanism of action upon the corpus cavernosum involves the release of nitric oxide. Injected intracavernosally it can produce penile erections, but its clinical usefulness has not been fully established.
Biological Activity
This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.
Biochem/physiol Actions
3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.
storage
Store at +4°C
References
[1] M NISHIKAWA H H M Kanamori. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites.[J]. Journal of Pharmacology and Experimental Therapeutics, 1982, 220 1: 183-190.
[2] N HOGG. Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide.[J]. Biochemical Journal, 1992, 281 ( Pt 2): 419-424. DOI:10.1042/bj2810419
[3] M KIRSCH. Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.[J]. The Journal of Biological Chemistry, 1998, 273 21: 12716-12724. DOI:10.1074/jbc.273.21.12716
[4] RAFFAELLA PRIORA . In vitro inhibition of human and rat platelets by NO donors, nitrosoglutathione, sodium nitroprusside and SIN-1, through activation of cGMP-independent pathways[J]. Pharmacological research, 2011, 64 3: Pages 289-297. DOI:10.1016/j.phrs.2011.03.014
[5] BAIPING REN. Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor[J]. ACS Omega, 2017, 2 1: 243-250. DOI:10.1021/acsomega.6b00397
3-Morpholinosydnonimine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Morpholinosydnonimine hydrochloride manufacturers
- Product
- 3-Morpholinosydnonimine hydrochloride 16142-27-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25