ChemicalBook > CAS DataBase List > 4-Bromo-2-methoxypyridine

4-Bromo-2-methoxypyridine

Product Name: 4-Bromo-2-methoxypyridine
CAS No.: 100367-39-3
Chemical Name: 4-Bromo-2-methoxypyridine
Synonyms: 4-BROMO-2-METHOXYPYRIDINE;2-Methoxy-4-broMoquinoline;Pyridine,4-bromo-2-methoxy-;4-Bromo-2-Methoxypyridine(WX637041);4-Bromo-2-methoxypyridine ISO 9001：2015 REACH
CBNumber: CB5371404
Molecular Formula: C6H6BrNO
Formula Weight: 188.02
MOL File: 100367-39-3.mol

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4-Bromo-2-methoxypyridine Property

Melting point:: 25-26℃
Boiling point:: 87℃/15mm
Density: 1.530±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.76±0.10(Predicted)
form: Low Melting Solid
color: Off-white to pale yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C6H6BrNO/c1-9-6-4-5(7)2-3-8-6/h2-4H,1H3
InChIKey: YFTGMMXMLPTTAY-UHFFFAOYSA-N
SMILES: C1(OC)=NC=CC(Br)=C1

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Safety

Hazard Codes: Xi
Safety Statements: 24/25
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B696885
Product name: 4-Bromo-2-methoxypyridine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: B696885
Product name: 4-Bromo-2-methoxypyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR11605
Product name: 4-Bromo-2-methoxypyridine
Packaging: 1g
Price: $17
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H07-9-Y0
Product name: 4-Bromo-2-methoxypyridine
Packaging: 1g
Price: $20
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: CAPOB12345
Product name: 4-Bromo-2-methoxypyridine
Purity: 95%
Packaging: 1g
Price: $23
Updated: 2021/12/16

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4-Bromo-2-methoxypyridine Chemical Properties,Usage,Production

Uses

4-Bromo-2-methoxypyridine used in the synhesis of Imidazo [1, 2-a] pyrimidines. Suzuki coupling between 4-methoxyphenylboronic acid and 4-bromo-2-methoxypyridine affords 1, 5-disubstituted pyridones. Starting material used in a synthesis of crown-ester-bipyridines and viologens via sodium or nickel reductive coupling, side chain oxidation and esterification.

Synthesis

128071-98-7

124-41-4

100367-39-3

A non-homogeneous reaction mixture formed by 4-bromo-2-fluoropyridine (2.64 mL, 25.6 mmol) and sodium methanolate (8.29 g, 153 mmol) in methanol (36.5 mL) was placed in a pressure tube and reacted for 5 hours at 155°C. Upon completion of the reaction, the mixture was cooled to room temperature, filtered to remove the solid insoluble material and the solids were washed with ethyl acetate. The filtrate was concentrated to give a light yellow oil containing a small amount of white solid. The yellow oily material was decanted, diluted with water and the aqueous phase was extracted with ethyl acetate (2×). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated to afford the target product 4-bromo-2-methoxypyridine (4.43 g, 21.20 mmol, 83% yield) as a yellow oil.LC-MS analysis: the calculated value of C6H6BrNO was 188.02, and the measured values of [M + H]+ were 187.9, 189.9. 1H NMR was used as the analyte. 189.9. 1H NMR (400 MHz, CDCl3) δ 7.98 (d, J = 5.5 Hz, 1H), 7.02 (dd, J = 5.5, 1.5 Hz, 1H), 6.94 (d, J = 1.8 Hz, 1H), 3.92 (s, 3H).

References

[1] Patent: WO2015/171722, 2015, A1. Location in patent: Page/Page column 67

4-Bromo-2-methoxypyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-2-methoxypyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 4-Bromo-2-methoxypyridine 100367-39-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-14

Henan Fengda Chemical Co., Ltd

Product: 4-Bromo-2-methoxypyridine 100367-39-3
Price: US $200.00-1.00/KG
Min. Order: 1KG
Purity: 99%, 99.5% Sublimated
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-30

Dideu Industries Group Limited

Product: 4-Bromo-2-methoxypyridine 100367-39-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-25

100367-39-3, 4-Bromo-2-methoxypyridineRelated Search:

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4-BROMO-2-METHOXYPYRIDINE

2-Methoxy-4-broMoquinoline

4-Bromo-2-Methoxypyridine(WX637041)

Pyridine,4-bromo-2-methoxy-

4-Bromo-2-methoxypyridine ISO 9001：2015 REACH

100367-39-3

10367-39-3

Heterocycle-Pyridine series

alkyl bromide

Pyridine Series

blocks

Bromides

Pyridines

Pyridine