ChemicalBook > CAS DataBase List > ARG-LYS-GLU-VAL-TYR ACETATE SALT

ARG-LYS-GLU-VAL-TYR ACETATE SALT

Product Name
ARG-LYS-GLU-VAL-TYR ACETATE SALT
CAS No.
105184-37-0
Chemical Name
ARG-LYS-GLU-VAL-TYR ACETATE SALT
Synonyms
SP-5 ACETATE SALT;Splenopentin diacetate;SPLENOPENTIN ACETATE SALT;ARG-LYS-GLU-VAL-TYR ACETATE;Splenopentin diacetate salt;SP-5, Splenin Fragment 32-36;Splenin pentapeptide (32-36);ARG-LYS-GLU-VAL-TYR ACETATE SALT;SPLENIN FRAGMENT 32-36 ACETATE SALT;Thymopoietin III pentapeptide (32-36)
CBNumber
CB5384574
Molecular Formula
C33H55N9O11
Formula Weight
753.84
MOL File
105184-37-0.mol
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ARG-LYS-GLU-VAL-TYR ACETATE SALT Property

storage temp. 
−20°C
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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ARG-LYS-GLU-VAL-TYR ACETATE SALT Chemical Properties,Usage,Production

Uses

Splenopentin diacetate is a synthetic immunomodulating pentapeptide corresponding to the residues 32-36 of the splenic hormone splenin. Splenopentin diacetate influences both early T and B cell differentiation, to increase the number of antibody-forming cells in mice after gamma irradiation[1][2].

Biological Activity

Splenopentin diacetate is a synthetic immunomodulatory pentapeptide corresponding to residues 32-36 of the spleen hormone spleen protein. It affects early T and B cell differentiation, thereby increasing the number of antibody-forming cells in gamma-irradiated mice.

in vitro

Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity.
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B -cell precursor cells.

in vivo

Splenopentin (1 mg/kg; ip three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice.
Splenopentin (0.01-100 μg per mouse; ip) has no demonstrable effect on neuromuscular transmission of mice.

Animal Model: Female Balb /c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days
Dosage: 1 mg /kg
Administration: Ip three times a week for 7-90 days
Result: Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.
Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops.

References

[1] Singh VK, et, al. Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res. 1998;17(3):345-68. DOI:10.1007/BF02786456
[2] Rastogi A, et, al. Augmentation of human natural killer cells by splenopentin analogs. FEBS Lett. 1993 Feb 8;317(1-2):93-5. DOI:10.1016/0014-5793(93)81498-o
[3] Audhya T, et, al. Contrasting biological activities of thymopoietin and splenin, two closely related polypeptide products of thymus and spleen. Proc Natl Acad Sci U S A. 1984 May;81(9):2847-9. DOI:10.1073/pnas.81.9.2847
[4] Gruner S, et, al. Stimulation of the recruitment of epidermal Langerhans cells by splenopentin. Arch Dermatol Res. 1990;281(8):526-9. DOI:10.1007/BF00412738

ARG-LYS-GLU-VAL-TYR ACETATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ARG-LYS-GLU-VAL-TYR ACETATE SALT manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
ARG-LYS-GLU-VAL-TYR ACETATE SALT 105184-37-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Splenopentin Acetate 105184-37-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Career Henan Chemical Co
Product
Splenopentin Acetate 105184-37-0
Price
US $9.80/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
20 tons
Release date
2020-01-09

105184-37-0, ARG-LYS-GLU-VAL-TYR ACETATE SALTRelated Search:

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  • ARG-LYS-GLU-VAL-TYR ACETATE SALT
  • SPLENIN FRAGMENT 32-36 ACETATE SALT
  • SPLENOPENTIN ACETATE SALT
  • SP-5 ACETATE SALT
  • ARG-LYS-GLU-VAL-TYR ACETATE
  • SP-5, Splenin Fragment 32-36, Splenopentin
  • L-Arginyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-tyrosine diacetate
  • Splenopentin diacetate
  • 4-[[6-amino-2-[[2-amino-5-(diaminomethylideneamino)-1-oxopentyl]amino]-1-oxohexyl]amino]-5-[[1-[[1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxopentanoic a
  • SP-5, Splenin Fragment 32-36
  • L-Tyrosine,N-[N-[N-(N2-L-arginyl-L-lysyl)-L-α-glutamyl]-L-valyl]-,diacetate (salt)
  • ARG-LYS-GLU-VAL-TYR ACETATE SALT USP/EP/BP
  • Splenin pentapeptide (32-36)
  • Thymopoietin III pentapeptide (32-36)
  • Splenopentin diacetate salt
  • splenin,Inhibitor,Splenopentin diacetate,synthetic,immunomodulating,splenic,differentiation,inhibit,hormone,antibody,pentapeptide
  • 105184-37-0
  • C31H51N9O9
  • C31H51N9O92C2H4O2
  • C33H55N9O11
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