Amyloid β-Peptide (1-42) (human)

Product Name: Amyloid β-Peptide (1-42) (human)
CAS No.: 107761-42-2
Chemical Name: Amyloid β-Peptide (1-42) (human)
Synonyms: TB500;Soy Peptide Powder;DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA;DA-42;soy peptide;β-Amyloid-42;Soy Oligopeptides;Amyloid β Protein Fragment 1-42;Amyloid β-Peptide (1-42) (human);Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
CBNumber: CB2139797
Molecular Formula: C203H311N55O60S1
Formula Weight: 4514.04
MOL File: 107761-42-2.mol

More

Less

Amyloid β-Peptide (1-42) (human) Property

storage temp.: -20°C
solubility: Soluble in ammonium hydroxide, pH >9. Also soluble in DMSO.
form: Lyophilized
color: Lyophilized White
Sequence: H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
InChIKey: XPESWQNHKICWDY-QYFPAAMGSA-N
CAS DataBase Reference: 107761-42-2(CAS DataBase Reference)

More

Less

Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29332900

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A9810
Product name: Amyloid β Protein Fragment 1-42
Packaging: 0.1mg
Price: $299
Updated: 2024/03/01

Sigma-Aldrich

Product number: 171596
Product name: β-Amyloid Peptide (1-42), Rat
Packaging: 250μg
Price: $445
Updated: 2024/03/01

Alfa Aesar

Product number: J66387
Product name: Amyloid beta (1-42), human
Packaging: 0.5mg
Price: $354
Updated: 2023/06/20

Alfa Aesar

Product number: J66387
Product name: Amyloid beta (1-42), human
Packaging: 1mg
Price: $564
Updated: 2023/06/20

Cayman Chemical

Product number: 20574
Product name: Amyloid-β (1-42) Peptide
Purity: ≥96%
Packaging: 1mg
Price: $276
Updated: 2021/12/16

More

Less

Amyloid β-Peptide (1-42) (human) Chemical Properties,Usage,Production

Chemical Properties

Lyophilized White solid, with no soy flavor, no protein denaturation, acidic non-precipitation, heating does not coagulate, easily soluble in water, good fluidity, and other good processing properties, is an excellent health food material.

Uses

Amyloid β-Peptide (1-42) (human)[107761-42-2], a major component of amyloid plaques, accumulates in neurons of Alzheimer's disease brains. Aβ(s) peptides, their peptide fragments and mutated fragments are used to study a wide range of metabolic and regulatory functions including activation of kinases, regulation of cholesterol transport, function as a transcription factor, and regulators of inflammation. Aβ(s) peptides and their peptide fragments are also used to study oxidative stress, metal binding and mechanisms of protein cross-linking in the context of diseases such as Alzheimer's disease and neurodegeneration.

Application

Amyloid beta (Aβ or Abeta) is a peptide of 36-C43 amino acids that is processed from the Amyloid precursor protein. Amyloid β-Peptide (1-42) human is a 42-amino acid peptide which plays a key role in the pathogenesis of Alzheimer disease. Beta-Amyloid (1-42) human is used as follows:
for the production of Aβ-1-42 oligomer;
in western blot analysis;
for interference testing of immunomagnetic reduction (IMR) plasma Aβ42 assay;
to study the effect of resveratrol on Aβ-1-42-induced impairment of spatial learning, memory, and synaptic plasticity;
to investigate the effect of Aβ in epithelial cell cultures.

General Description

Amyloid β Protein is produced from amyloid-β precursor protein (APP). It consists of two C terminal variants, such as a long tailed Aβ 1-42 and a short tailed Aβ 1-40. APP is located on human chromosome 21q21.3.

Biochem/physiol Actions

Amyloid β-Peptide (1-42) (human) is a human form of the predominant amyloid β-peptide found in the brains of patients with Alzheimer's disease. Amyloid β Protein Fragment 1-42 (Aβ 1-42) has antioxidant and neuroprotective properties. Accumulation of amyloid β Protein is associated with Alzheimer′s disease (AD) and Down Syndrome. Aβ 1-42 regulates cholesterol transport and may function as a transcription factor. It may possess anti-inflammatory and antimicrobial properties. Downregulates bcl-2 and increases the levels of bax. Neurotoxic.

storage

-20°C

References

[1] CHEN L M, CHAI K X. Matriptase cleaves the amyloid-beta peptide 1–42 at Arg-5, Lys-16, and Lys-28[J]. BMC Research Notes, 2019, 12. DOI:10.1186/s13104-018-4040-z.
[2] BROWN A M, BEVAN D R. Influence of sequence and lipid type on membrane perturbation by human and rat amyloid β-peptide (1-42).[J]. Archives of biochemistry and biophysics, 2015, 614: 1-13. DOI:10.1016/j.abb.2016.11.006.
[3] MENGTING YANG. Gel Phase Membrane Retards Amyloid β-Peptide (1–42) Fibrillation by Restricting Slaved Diffusion of Peptides on Lipid Bilayers[J]. Langmuir, 2018, 34 28: 8408-8414. DOI:10.1021/acs.langmuir.8b01315.
[4] LIANG SHEN Hong F J. Comparative study on the conformational stability of human and murine amyloid β peptide[J]. Computational and Theoretical Chemistry, 2011, 972 1: Pages 44-47. DOI:10.1016/j.comptc.2011.06.012.
[5] MOUCHARD A, BOUTONNET M C, MAZZOCCO C, et al. ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer’s disease[J]. Scientific Reports, 2019, 9. DOI:10.1038/s41598-019-40438-4.

Amyloid β-Peptide (1-42) (human) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Amyloid β-Peptide (1-42) (human) Suppliers

China 269 Europe 1 France 1 Germany 4 India 2 Switzerland 1 United Kingdom 5 United States 24 Global 307

GL Biochem (Shanghai) Ltd

Tel: 21-61263452 13641803416
Fax: 86-21-61263399
Email: ymbetter@glbiochem.com
Country: China
ProdList: 9981
Advantage: 64

Binhai gill polypeptide co. LTD

Tel: 021-61263389 13524856427
Fax: WeChat630417570
Email: Joetang@glschina.com
Country: China
ProdList: 10012
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Fax: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 6968
Advantage: 58

Xi`an Tian Guangyuan Biotech Co., Ltd.

Tel: 17391926474
Email: 2539013658@qq.com
Country: China
ProdList: 205
Advantage: 58

Nanjing Yuanpeptide Biotech Co.，Ltd.

Tel: 18168071971
Email: support@yuan-peptide.com
Country: China
ProdList: 2980
Advantage: 58

Zhongke Huayao (Jiangsu) Biotechnology Co., Ltd

Tel: 13770887460
Email: wenxi@jszkhy.com
Country: China
ProdList: 1351
Advantage: 58

Nanjing Peptide Biotech Ltd.

Tel: 025-025-58361106-805-805 13082558573
Fax: 025-58361106-806
Email: liugang@njpeptide.com
Country: China
ProdList: 9980
Advantage: 55

Hebei Zhoufeng Technology Co., Ltd

Tel: 18833916855 18833916855
Email: 514033631@qq.com
Country: China
ProdList: 1234
Advantage: 58

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Alabiochem Tech.Co., Ltd.

Tel: 512-58900862 400-0707518
Fax: 0086-512-56765862
Email: sales@alabiochem.com
Country: China
ProdList: 968
Advantage: 59

More

Less

View Lastest Price from Amyloid β-Peptide (1-42) (human) manufacturers

Huaian Banting Trading Co., Ltd.

Product: Thymosin B4 Acetate 107761-42-2
Price: US $80.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 1000box/month
Release date: 2024-12-26

Huaian Banting Trading Co., Ltd.

Product: Thymosin beta 4 107761-42-2
Price: US $80.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 1000box/month
Release date: 2024-12-26

Huaian Banting Trading Co., Ltd.

Product: TB500 107761-42-2
Price: US $80.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 1000box/month
Release date: 2024-11-14

107761-42-2, Amyloid β-Peptide (1-42) (human)Related Search:

α-Lipoic Acid Diethylstilbestrol Oxytocin Amyloid β-Protein (1-42) (mouse, rat) AMYLOID BETA-PROTEIN (29-40) H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-OH H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE H-ILE-ILE-GLY-LEU-MET-OH H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH AMYLOID BETA-PROTEIN (1-15) H-CYS-SER-CYS-SER-SER-TRP-LEU-ASP-LYS-GLU-CYS-VAL-TYR-PHE-CYS-HIS-LEU-ASP-ILE-ILE-TRP-OH PHENYLSELENOL Aluminum acetylacetonate Benzyl isocyanide TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) SALCOMINE

Bate-Amyloid（1-42）human

</span> (1-42) (human)

AB42, betaamyloid peptide

Amyloid <span class="symbol">&beta

H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

REF DUPL: H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

Beta-Amyloid (1-42), sodium salt

Β-AMYLOID PEPTIDE (1-42), RAT

Amyloid β-Peptide (1-42) (human)

AMyloid (1-42) huMan peptide

HuMan β-aMyloid peptide-(1-42)

AMyloid b-Protein (1-42)

β-AMyloid Peptide (1-42),rat,β-AMyloid Peptide (1-42),rat

Beta-AMyloid(1-42)TB500

TB500

Soy Oligopeptides

Amyloid-β (1-42) Peptide

Amyloid|A-Peptide (1-42) (human)

Amyloid β Protein Fragment 1-42, ≥95% (HPLC)

L-alpha-Aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-serylglycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine

M.W. 4514.08 C203H311N55O60S

Amyloid β-Protein (1-42) (HFIP-treated)

Amyloid β-Protein (1-42) sodium salt

β–Amyloid (1-42), Amyloid β-Protein (Human, 1-42)

2-Amyloid(1-42) Human

soy peptide

1-42 Amyloid β Protein Fragment 1-42,human

Amyloid beta Protein fragment 1-42 HCl Salt

Human beta-amyloid peptide (1-42)

Amyloid β-Protein (1-42) hydrochloride salt

Bate-Amyloid(1-42)

BETA-AMYLOID PEPTIDE (1-42), HUMAN

DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA

AMYLOID BETA-PEPTIDE (1-42) (HUMAN)

AMYLOID B-PROTEIN FRAGMENT 1-42

Amyloidb-Peptide(1-42)(human)

H-Asp-Ala-Glu-Phe-Arg-His-Asp--Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-OH

SS-AMYLOID PEPTIDE (1-42), RAT

H-asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Ile-Ala-OH

Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala

beta-Amyloid (1-42) human

Amyloid beta-Protein (1-42) hydrochloride salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH hydrochloride salt

Amyloid beta-Protein (1-42) sodium salt

Amyloid beta-Protein (1-42) trifluoroacetate salt H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH trifluoroacetate salt

Amyloid β-Peptide (1-42) (human) TFA

β-Amyloid-42

β-Amyloid: 1-42,human

Amyloid β-Peptide (12-28) (human)

Amyloid β Protein Fragment 1-42

DA-42

Amyloid β-Peptide (1-42)

beta-Amyloid (1-42) human USP/EP/BP

β-Amyloid (1-42), human TFA

Amyloid β-Protein (1-42)

Amyloid-β (1-42) Peptide

Amyloid β-Protein (1-42) (HFIP-treated)

Soy Peptide Powder

β–Amyloid (1-42), human, Amyloid β-Protein (Human, 1-42)