2-Bromopyridine-5-carbaldehyde

Product Name: 2-Bromopyridine-5-carbaldehyde
CAS No.: 149806-06-4
Chemical Name: 2-Bromopyridine-5-carbaldehyde
Synonyms: 6-BROMONICOTINALDEHYDE;2-BROMO-5-FORMYLPYRIDINE;6-BROMO-PYRIDINE-3-CARBALDEHYDE;6-BROMO-3-PYRIDINECARBOXALDEHYDE;6-BROMOPYRIDINE-3-CARBOXALDEHYDE;2-Bromo-5-aldopyridine;Abemaciclib Impurity 37;6-Bromo-3-pyridinecarboxaL;2-BROMO-5-FORMYLPYRIDINE97+%;2-BroMopridine-5-carbaldehyde
CBNumber: CB5396137
Molecular Formula: C6H4BrNO
Formula Weight: 186.01
MOL File: 149806-06-4.mol

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2-Bromopyridine-5-carbaldehyde Property

Melting point:: 104-110 °C(lit.)
Boiling point:: 284°
Density: 1.683
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Soluble in dichloromethane, ether, ethyl acetate and methanol.
form: Solid
pka: -1.01±0.10(Predicted)
color: Pale yellow
Sensitive: Air Sensitive
InChI: InChI=1S/C6H4BrNO/c7-6-2-1-5(4-9)3-8-6/h1-4H
InChIKey: PVUKGNBRJFTFNJ-UHFFFAOYSA-N
SMILES: C1=NC(Br)=CC=C1C=O
CAS DataBase Reference: 149806-06-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 596280
Product name: 6-Bromo-3-pyridinecarboxaldehyde
Purity: 95%
Packaging: 1g
Price: $14.9
Updated: 2025/07/31

Sigma-Aldrich

Product number: 596280
Product name: 6-Bromo-3-pyridinecarboxaldehyde
Purity: 95%
Packaging: 5g
Price: $92.4
Updated: 2025/07/31

TCI Chemical

Product number: B3491
Product name: 6-Bromo-3-pyridinecarboxaldehyde
Purity: >98.0%(GC)
Packaging: 1g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: B3491
Product name: 6-Bromo-3-pyridinecarboxaldehyde
Purity: >98.0%(GC)
Packaging: 5g
Price: $87
Updated: 2025/07/31

Sigma-Aldrich

Product number: 596280
Product name: 6-Bromo-3-pyridinecarboxaldehyde
Purity: 95%
Packaging: 25g
Price: $349
Updated: 2025/07/31

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2-Bromopyridine-5-carbaldehyde Chemical Properties,Usage,Production

Chemical Properties

Light yellow Cryst

Uses

A useful synthetic intermediate. 6-Bromonicotinaldehyde is used in wittig reaction. Hydrodehalogenation of 6-bromonicotinaldehyde to produce alcohol.

Uses

2-Bromopyridine-5-carbaldehyde can be a useful synthetic intermediate

Synthesis

154321-32-1

149806-06-4

General procedure for the synthesis of 2-bromo-5-formylpyridine (Intermediate 1b) from 2-bromo-5-(dibromomethyl)pyridine (Intermediate Ia, 3.650 g, 11.07 mmol): a mixture of Intermediate Ia with calcium carbonate (2.437 g, 24.35 mmol) in water (80 ml) was stirred and reacted for 16 hours at 105 °C. After completion of the reaction, the mixture was cooled to room temperature, diluted with water and extracted twice with ethyl acetate (EtOAc). The organic phases were combined, washed sequentially with water and saturated sodium chloride (NaCl) solution, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give Intermediate 1b (1.890 g, 92% yield). The product was characterized by 1H NMR (500 MHz, CDCl3): δ 10.05 (s, 1H), 8.78 (d, J = 2.2 Hz, 1H), 7.98 (dd, J = 8.2,2.4 Hz, 1H), 7.65 (d, J = 8.2 Hz, 1H).

References

[1] Patent: WO2016/124747, 2016, A1. Location in patent: Page/Page column 58; 59
[2] Patent: US2018/202388, 2018, A1
[3] Tetrahedron Letters, 2005, vol. 46, # 36, p. 6033 - 6036
[4] Synthesis, 1994, # 1, p. 87 - 92

2-Bromopyridine-5-carbaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromopyridine-5-carbaldehyde Suppliers

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View Lastest Price from 2-Bromopyridine-5-carbaldehyde manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 6-Bromonicotinaldehyde 149806-06-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-26

Moxin Chemicals

Product: Abemaciclib Impurity 37 149806-06-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 95%+
Supply Ability: 10000
Release date: 2025-03-05

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Bromopyridine-5-Carbaldehyde 149806-06-4
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-14

149806-06-4, 2-Bromopyridine-5-carbaldehydeRelated Search:

3-Aminopyridine 4-Methylpyridine Chromium picolinate Sulfasalazine 1-Hexadecylpyridinium bromide 2-Carboxybenzaldehyde 2-Bromopyridine 6-Bromonicotinic acid 5,6-DIBROMOPYRIDINE-3-CARBOXYLIC ACID t-butyl 6-bromo-3-pyridinecarboxylate N-methyl 2-bromo-5-pyridinecarboxamide 2-Bromo-5-formyl-3-methylpyridine 1-(6-BROMO-PYRIDIN-3-YL)-ETHANONE Methyl 6-bromonicotinate 6-BROMONICOTINAMIDE 98 5-Bromo-3-formylpyridine 2-Bromopyridine-4-carbaldehyde ,97%,2-BROMOPYRIDINE-4-CARBALDEHYDE 1-(6-BROMO-PYRIDIN-3-YL)-2,2,2-TRIFLUORO-ETHANONE

2-BROMO-5-FORMYLPYRIDINE

2-BROMOPYRIDINE-5-CARBALDEHYDE

2-BROMOPYRIDINE-5-CARBOXALDEHYDE

2-BROMO-5-PYRIDINECARBOXALDEHYDE

6-BROMONICOTINALDEHYDE

6-BROMO-PYRIDINE-3-CARBALDEHYDE

6-BROMOPYRIDINE-3-CARBOXALDEHYDE

6-BROMO-3-PYRIDINECARBOXALDEHYDE

2-BROMO-5-FORMYLPYRIDINE97+%

6-Bromo-3-pyridinecarboxaldehyde,95%

6-Bromopyridine-3-carboxaldehyde, 6-Bromo-3-formylpyridine

2-Bromo-5-formylpyridine 6-Bromonicotinaldehyde

2-BroMopridine-5-carbaldehyde

3-Pyridinecarboxaldehyde,6-broMo-

6-BroMo-3-pyridinecarboxaldehyde, 98%, 98%

6-Bromo-3-pyridinecarboxaldehyde 95%

6-Bromopyridine-3-carboxaldehyde, 2-Bromo-5-formylpyridine

6-Bromo-3-pyridinecarbaldehyde

6-Bromo-3-pyridinecarboxaldehyde &gt

6-Bromopyridine-3-carboxaldehyde, 98%, for synthesis

2-Bromo-5-aldopyridine

6-Bromo-3-pyridinecarboxaL

2-Bromopyridine-5-carbaldehyde ISO 9001：2015 REACH

TIANFU CHEM-- 2-Bromopyridine-5-carbaldehyde

2- bromo -5- aldehyde pyridine

2-BROMO-5-PYRIDINECARBOXALDEHYDEChemicalbook

Abemaciclib Impurity 37

149806-06-4

34160-40-3

Heterocyclic Building Blocks

Halogenated Heterocycles

Pyridines

Building Blocks

Heterocycle-Pyridine series

C1 to C6

C5 to C6

C6 to C7

Chemical Synthesis

Halogenated Heterocycles

Heterocyclic Building Blocks

Organic Building Blocks

Bases & Related Reagents

Nucleotides

C6Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridine Series

pharmacetical

Aldehydes

Pyridines

Aldehyde

Building Blocks

Nucleotides and Nucleosides

Carbonyl Compounds

Heterocycles

Pyridine