Zipeprol dihydrochloride

Product Name
Zipeprol dihydrochloride
CAS No.
34758-84-4
Chemical Name
Zipeprol dihydrochloride
Synonyms
3024CERM;CERM3024;Respilene;ZIPEPROL DIHYDROCHLORIDE;MJKMHVIKCKUYTR-UHFFFAOYSA-N;alpha-(methoxybenzyl)-4-(2-methoxyphenetyl)piperazine-1-ethanol dihydrochloride;alpha-(Methoxybenzyl)-4-(2-methoxy-2-phenylethyl)piperazine-1-ethanol dihydrochloride
CBNumber
CB5401886
Molecular Formula
C23H34Cl2N2O3
Formula Weight
457.43
MOL File
34758-84-4.mol
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Zipeprol dihydrochloride Property

Melting point:
231°
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Safety

Toxicity
LD50 orally in mice: 301 mg/kg (Rispat)
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Hazard and Precautionary Statements (GHS)

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Zipeprol dihydrochloride Chemical Properties,Usage,Production

Originator

Respilene,Winthrop,France,1973

Uses

Zipeprol dihydrochloride is a piperazine ethanol derivative that is a widely used pediatric antitussive. Zipeprol dihydrochloride has cytotoxic and immunomodulative effects on human peripheral blood lymphocytes. Zipeprol dihydrochloride has a novel spectrum of action involving opioid and non-opioid effects with possible abuse potential.

Manufacturing Process

In a reactor provided with a mechanical stirrer, a reflux refrigerant and a thermometer, there is introduced: 393 grams 1-[2-phenyl, 2-methoxy]ethyl piperazine and 22 grams 3-phenyl-3-methoxy propylene oxide in 750 ml of absolute ethanol.
When the slightly exothermic reaction (rise in temperature of about 20°C) has ceased, heating is effected for 1.5 hours at 60°C. The product is then cooled to 4°C and left to crystallize for about 12 hours. The precipitate is centrifugated then recrystallized in 500 ml of absolute ethanol.
420 grams of the desired compound is thus obtained in the form of a white, crystalline powder, melting point 83°C.

Therapeutic Function

Bronchodilator

Zipeprol dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Zipeprol dihydrochloride Suppliers

34758-84-4, Zipeprol dihydrochlorideRelated Search:


  • ZIPEPROL DIHYDROCHLORIDE
  • alpha-(methoxybenzyl)-4-(2-methoxyphenetyl)piperazine-1-ethanol dihydrochloride
  • alpha-(Methoxybenzyl)-4-(2-methoxy-2-phenylethyl)piperazine-1-ethanol dihydrochloride
  • 3024CERM
  • Respilene
  • CERM3024
  • MJKMHVIKCKUYTR-UHFFFAOYSA-N
  • 34758-84-4
  • C23H32N2O32HCl