Trichlormethiazide

Product Name: Trichlormethiazide
CAS No.: 133-67-5
Chemical Name: Trichlormethiazide
Synonyms: TRICLORMETIAZIDA;TRICHLOROMETHIAZIDE;Naqua;Flurese;Naquival;Metahydrin;Navis;Nydor;Nakva;Natril
CBNumber: CB5407444
Molecular Formula: C8H8Cl3N3O4S2
Formula Weight: 380.66
MOL File: 133-67-5.mol

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Trichlormethiazide Property

Melting point:: 248-250℃
Boiling point:: 631.3±65.0 °C(Predicted)
Density: 1.748
refractive index: 1.6000 (estimate)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: pKa 6.9(acetone/H2O) (Uncertain)
color: White to Off-White
Merck: 14,9624
CAS DataBase Reference: 133-67-5(CAS DataBase Reference)
EPA Substance Registry System: Trichlormethiazide (133-67-5)

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Safety

Hazard Codes: Xn
Risk Statements: 42/43
Safety Statements: 36
WGK Germany: 2
RTECS: DK8925000
HS Code: 2935904000
Hazardous Substances Data: 133-67-5(Hazardous Substances Data)
Toxicity: LD50 orally in rats: >20000 mg/kg (Goldenthal)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H317May cause an allergic skin reaction

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1681000
Product name: Trichlormethiazide
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $358
Updated: 2024/03/01

TCI Chemical

Product number: T1318
Product name: Trichloromethiazide
Purity: >99.0%(T)
Packaging: 10g
Price: $204
Updated: 2024/03/01

Cayman Chemical

Product number: 29331
Product name: Trichlormethiazide
Packaging: 1g
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29331
Product name: Trichlormethiazide
Packaging: 5g
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 29331
Product name: Trichlormethiazide
Packaging: 10g
Price: $169
Updated: 2024/03/01

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Trichlormethiazide Chemical Properties,Usage,Production

Chemical Properties

Trichlormethiazide occurs as a white or practically white, crystalline powder and may have a slight characteristic odor.

Originator

Naqua,Schering,US,1960

Uses

diuretic, antihypertensive

Uses

Trichlormethiazide, is a diuretic, having similar properties as Hydrochlorothiazide (H714560). It is used for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension.

Uses

Trichlormethiazide is a diuretic and anti-hypertensive agent from the benzothiadiazide class which is used in veterinary medicine in cattle, sheep, goats, pigs and horses, at the following therapeutic regimen: a single intramuscular dose of 0.4 mg/kg bw followed by two oral doses of 0.8 mg/kg bw given 12 and 36 hours after the first administration.
Trichlormethiazide is also used in humans in the United States as a diuretic and anti-hypertensive substance but not in the European Union. The usual dose is 2 to 4 mg twice a day (i.e. approximately 0.033 to 0.066 mg/kg bw/day).

Definition

ChEBI: Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.

Manufacturing Process

A mixture of 5.7 grams (0.02 mol) of 5-chloro-2,4-disulfamylaniline and 4.9 grams (0.04 mol) of dichloroacetaldehyde in 25 ml of dimethyl formamide was heated at the boiling temperature and under reflux for 30 minutes. The reaction mixture was thereafter poured into a mixture of ice and water to precipitate the desired 6-chloro-7-sulfamyl-3-dichloromethyl-3,4-dihydro- 1,2,4-benzothiadiazine-1,1-dioxide as a crystalline solid melting at 250° to 270°C with decomposition.

Therapeutic Function

Diuretic

Trichlormethiazide Preparation Products And Raw materials

Raw materials

Preparation Products

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Trichlormethiazide Suppliers

China 137 Germany 3 India 5 Japan 1 South Korea 1 Switzerland 1 United Kingdom 3 United States 27 Global 178

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View Lastest Price from Trichlormethiazide manufacturers

Hebei Miaoyin Technology Co.,Ltd

Product: Trichlormethiazide 133-67-5
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000
Release date: 2023-04-13

Hebei Yanxi Chemical Co., Ltd.

Product: Trichlormethiazide 133-67-5
Price: US $40.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-09-18

Shaanxi Franta Biotechnology Co., Ltd

Product: Trichlormethiazide 133-67-5
Price: US $20.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 1000kg
Release date: 2024-03-28

133-67-5, TrichlormethiazideRelated Search:

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6-CHLORO-3-DICHLOROMETHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE

6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonamid

6-Chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-thiadiazine-7-sulfonamide1,1-dioxide

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide

6-chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1

6-Chloro-3-(dichloromethyl)3,4-dihydro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide

6-chloro-3-dichloromethyl-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio

Achletin

Anistadin

Aponorin

Carvacron

Chlopolidine

Ciba 7057-Su

ciba7057-su

component of Metatensin

component of Naquival

Cretonin

Diu-Hydrin

Diurazida

Diurese

Diuroral

Trichlormethiazid

Trichloromethiadiazide

Triclordiuride

Triclormetiazide

Triflumen

3-Dichlormethylhydrochlorothiazide

TRICHLORMETHIAZIDE,USP

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide (6CI, 8CI, 9CI)

6-Chloro-3-dichloromethyl-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide

NSC 61560

Salirom

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide, (-)- (9CI)

Natril

Navis

Nydor

Pluvex

6-chloro-3-(dichloromethyl)-1,1-diketo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide

Trichlormethiazide (200 mg)

TRICLORMETIAZIDA

trichlormethtazide

TRICHLORMETHIAZIDE

TRICHLOROMETHIAZIDE

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-dioxide

2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(dichloromethyl)-3,4-dihydr

3-(Dichloromethyl)-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

3-dichloromethyl-6-chloro-7-sulfamoyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1

3-Dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-d

3-dichloromethyl-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine1,1-dio

3-dichloromethylhydrochlorothiazide

6-chloro-3-(dichloromethyl)-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulfonam

e1,1-dioxide

Esmarin

Eurinol

Fluitran

Flurese