N-Hydroxyacetamidine

Product Name: N-Hydroxyacetamidine
CAS No.: 22059-22-9
Chemical Name: N-Hydroxyacetamidine
Synonyms: acetamidoxime;METHYLAMIDOXIME;ACETAMIDE OXIME;Acetamidoxime >N-HYDROXYACETAMIDINE;ethylidyne amidoxime;Acetamide oxime, 95+%;N2-Hydroxyethanamidine;n-hydroxyethanimidamide;n-hydroxy-ethanimidamid
CBNumber: CB5431537
Molecular Formula: C2H6N2O
Formula Weight: 74.08
MOL File: 22059-22-9.mol

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N-Hydroxyacetamidine Property

Melting point:: 134 °C
Boiling point:: 110.6±23.0 °C(Predicted)
Density: 1.19±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: soluble in Methanol
pka: 7.48±0.69(Predicted)
form: Powder, Crystals and/or Chunks
color: White
InChI: InChI=1S/C2H6N2O/c1-2(3)4-5/h5H,1H3,(H2,3,4)
InChIKey: AEXITZJSLGALNH-UHFFFAOYSA-N
SMILES: C(NO)(=N)C

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-36/37/39-37/39
RTECS: AC6900000
HazardClass: IRRITANT
HS Code: 29280000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: A2646
Product name: Acetamidoxime
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $82
Updated: 2025/07/31

TCI Chemical

Product number: A2646
Product name: Acetamidoxime
Purity: >97.0%(GC)(T)
Packaging: 25g
Price: $262
Updated: 2025/07/31

GFS CHEMICALS

Product number: 10061
Product name: ACETAMIDEOXIME
Packaging: 25g
Price: $160.09
Updated: 2021/12/16

Usbiological

Product number: 459190
Product name: N-Hydroxyacetamidine
Packaging: 100mg
Price: $305
Updated: 2021/12/16

TRC

Product number: H827803
Product name: N-Hydroxyacetamidine
Packaging: 100mg
Price: $45
Updated: 2021/12/16

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N-Hydroxyacetamidine Chemical Properties,Usage,Production

Chemical Properties

White crystals

Uses

N-Hydroxyacetamidine is a useful research chemical used in the preparation of amidoximes and related compounds.

Synthesis

75-05-8

22059-22-9

The general procedure for the synthesis of N'-hydroxyacetamidine from acetonitrile is as follows:(a) Preparation of N-hydroxyacetamidine amide: Phenolphthalein (0.05 g) was added to a solution of hydroxylamine hydrochloride (35 g, 0.5 mol) in ethanol (200 ml) as an indicator. Sodium ethanol solution (324 ml, 21% v/v) was added slowly over a period of 1 hour. After 3 hours of reaction, acetonitrile (13.8 g) was added and the reaction was stirred at room temperature for 2 hours followed by heating at 40°C for 48 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered and the solvent was removed under reduced pressure. The residue was allowed to stand at room temperature for 48 h. Methanol (1 liter) was then added to dissolve the crude product and it was adsorbed onto silica. Purification by silica column chromatography using 9:1 dichloromethane:methanol as eluent gave the target product N'-hydroxyacetamidine (20.33 g, 81% yield). The product was characterized by 1H NMR (d6-DMSO): δ = 1.60 (3H, s), 5.33 (2H, br), 8.65 (1H, s).

References

[1] Patent: EP1157002, 2005, B1. Location in patent: Page/Page column 26
[2] Patent: WO2017/50969, 2017, A1. Location in patent: Page/Page column 14; 15
[3] Patent: WO2004/50650, 2004, A1. Location in patent: Page 103
[4] Patent: US2004/162276, 2004, A1. Location in patent: Page 22
[5] Patent: WO2015/118342, 2015, A1. Location in patent: Page/Page column 68

N-Hydroxyacetamidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-Hydroxyacetamidine Suppliers

Americas 1 Belgium 3 China 112 Europe 1 France 2 Germany 4 India 8 Japan 1 Poland 1 South Korea 1 Sweden 2 The Netherlands 1 Ukraine 2 United Kingdom 8 United States 40 Global 187

Shanghai Chainpharm Bio-medical Technology Co., Ltd.

Tel: +86-021-61727342 13611721451
Fax: 021-61294107
Email: chainpharm@163.com
Country: China
ProdList: 980
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Ark Pharm, Inc.

Tel: 847-367-3680
Fax: 847-367-3681
Email: sales@arkpharminc.com
Country: United States
ProdList: 1670
Advantage: 56

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
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Country: China
ProdList: 35896
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Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
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Jia Xing Isenchem Co.,Ltd

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Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
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Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

shanghai Rainbow MediTech.Co.Ltd.

Tel: 021-64968085,64968086-5815,5812; 13472757003
Fax: +86 21 64968087
Email: xiaoxia.zeng@rainbowpharma.cn
Country: China
ProdList: 961
Advantage: 65

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View Lastest Price from N-Hydroxyacetamidine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Hydroxyacetamidine 22059-22-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-Hydroxyacetamidine 22059-22-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: N-Hydroxyacetamidine 22059-22-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95%-99%
Supply Ability: 100KG
Release date: 2019-08-29

22059-22-9, N-HydroxyacetamidineRelated Search:

2'-Hydroxyacetophenone 1-Hydroxyethylidene-1,1-diphosphonic acid Hydroxy silicone oil 4'-Hydroxyacetophenone Acetamidine hydrochloride HYDROXYAPATITE TYPE I Glycolic acid 2-HYDROXYACETAMIDE 4-Hydroxybenzaldehyde Trifluoroacetamidine 2-AMINO-2-METHYL-PROPIONITRILE N-Hydroxysuccinimide N-Hydroxyphthalimide N-Hydroxysulfosuccinimide sodium salt 2-(4-FLUOROBENZYLSULFONYL)ACETAMIDOXIME 2-PIPERIDINOACETAMIDOXIME 2-Pyridylamid oxime (1E)-N'-HYDROXY-2-PHENYLETHANIMIDAMIDE

n-hydroxy-ethanimidamid

n-hydroxyethanimidamide

(1E)-N'-HYDROXYETHANIMIDAMIDE

ACETAMIDE OXIME

METHYLAMIDOXIME

ethylidyne amidoxime

N-HYDROXYACETAMIDINE

Acetamide oxime, 95+%

(1Z)-N'-hydroxyethanimidamide

1-(Hydroxyamino)-1-ethanimine

1-(Hydroxyimino)ethanamine

N2-Hydroxyethanamidine

ethanimidamide, N'-hydroxy-, (1Z)-

Acetamide oximeN-Hydroxyacetamide

(Z)-N'-hydroxyacetiMidaMide

(E)-N'-hydroxyacetiMidaMide

AcetaMide oxiMe, 95+% 1GR

AcetaMide oxiMe, 95+% 5GR

acetamidoxime

(3E)-3-(hydroxyiMino)propanaMide

Acetamidoxime &gt

Ethanimidamide, N-hydroxy- (9CI)

N'-Hydroxyacetimidamide

N'-hydroxyethanimidamide

N-Hydroxyacetamidine, 97%

N′-hydroxyethanimidamide, CAS 22059-22-9

22059-22-9

CH3CNH2NOH

CH3CNOHNH2

pharmacetical