ChemicalBook > CAS DataBase List > Bisphenol AF

Bisphenol AF

Product Name: Bisphenol AF
CAS No.: 1478-61-1
Chemical Name: Bisphenol AF
Synonyms: BPAF;BISPHENOL AF;2,2-BIS(4-HYDROXYPHENYL)HEXAFLUOROPROPANE;BIS-AF;BISPHENOL AF-M;4,4'-(HEXAFLUOROISOPROPYLIDENE)DIPHENOL;BPAF-d4;2,2′4,4&priMe;biphenolaf
CBNumber: CB5432266
Molecular Formula: C15H10F6O2
Formula Weight: 336.23
MOL File: 1478-61-1.mol

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Bisphenol AF Property

Melting point:: 160-163 °C(lit.)
Boiling point:: 400°C
Density: 1.3837 (estimate)
vapor pressure: 0Pa at 20℃
Flash point:: >100°C
storage temp.: Inert atmosphere,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 8.74±0.10(Predicted)
form: powder
color: White to Pale Beige
Water Solubility: Insoluble in water.
BRN: 1891568
InChIKey: ZFVMWEVVKGLCIJ-UHFFFAOYSA-N
LogP: 2.79 at 20℃
CAS DataBase Reference: 1478-61-1(CAS DataBase Reference)
EPA Substance Registry System: Phenol, 4,4'-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis- (1478-61-1)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 2
RTECS: SN2780000
Hazard Note: Corrosive
TSCA: Yes
HS Code: 29081990
Hazardous Substances Data: 1478-61-1(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 257591
Product name: 4,4′-(Hexafluoroisopropylidene)diphenol
Purity: 97%
Packaging: 25g
Price: $245
Updated: 2025/07/31

Sigma-Aldrich

Product number: 257591
Product name: 4,4′-(Hexafluoroisopropylidene)diphenol
Purity: 97%
Packaging: 100g
Price: $825
Updated: 2023/06/20

TCI Chemical

Product number: B0945
Product name: 2,2-Bis(4-hydroxyphenyl)hexafluoropropane
Purity: >98.0%(GC)
Packaging: 5g
Price: $19
Updated: 2025/07/31

TCI Chemical

Product number: B0945
Product name: 2,2-Bis(4-hydroxyphenyl)hexafluoropropane
Purity: >98.0%(GC)
Packaging: 25g
Price: $49
Updated: 2025/07/31

Sigma-Aldrich

Product number: 90477
Product name: BisphenolAF
Purity: analytical standard
Packaging: 100mg
Price: $73
Updated: 2025/07/31

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Bisphenol AF Chemical Properties,Usage,Production

Chemical Properties

white to off-white powder

Uses

fluororubber crosslinking agent

Uses

Hexafluorobisphenol A mainly is used for fluorine rubber vulcanization accelerator FF34 with fluorine rubber, vulcanized permanent deformation resistance, tensile strength is high; but also can be used as pharmaceutical intermediates.

Uses

Hexafluorobisphenol A acts as an endocrine-disrupting chemical (EDC), activating estrogen through the estrogen receptor ERα. It is a full agonist for the estrogen receptor.

Definition

ChEBI: An organofluorine compound that is bisphenol A with its methyl hydrogens replaced by fluorines.

Hazard

Moderately toxic by ingestion.

Flammability and Explosibility

Not classified

Synthesis

684-16-2

108-95-2

1478-61-1

To a 500mL stainless steel autoclave equipped with a stirrer, gas introduction valve, thermocouple, manometer and siphon tube was added 75.2 g (0.80 mol) of molten phenol and cooled in an ice bath. When the internal temperature dropped below 10°C, an appropriate amount (12.05 mol) of HF was added, followed by 106.3 g (0.64 mol) of hexafluoroacetone (HFA) (the molar ratio of HFA to phenol was 0.8 and the molar ratio of HF to phenol was 15). The autoclave was sealed, stirred and heated up to 100 °C, and the reaction was maintained at this temperature for 2 hours. Upon completion of the reaction, analysis showed 96.2% of the target product 2,2-bis(4-hydroxyphenyl)hexafluoropropane (bisphenol AF) in the reaction solution (organic phase), with the remaining components being 0.1% phenol, 0.1% intermediate 2-(4-hydroxyphenyl)hexafluoropropan-2-ol, 2.9% intermediate isomer 2-(2-hydroxyphenyl)hexafluoropropan-2-ol, 0.4% bisphenol AF isomer, 0.2% HFA adduct of bisphenol AF and 0.1% other impurities. After the reaction, the autoclave was cooled to below 30 °C in an ice bath, and 388.4 g of the reaction solution was transferred to a HFA/HF recovery tower condenser pre-cooled to -15 °C using nitrogen pressure through a pipe connecting the outlet of the autoclave siphon and the bottom liquid transfer valve (capacity: 500 mL) to prevent the escape of HFA and HF. After the transfer was complete, the autoclave was removed and the bottom of the recovery tower was heated with a 40°C oil bath. After about 20 minutes, full reflux of the HFA/HF mixture was started, at which time the temperature at the bottom was 25.2°C and the temperature at the top of the tower was 16.9°C. After 30 minutes of full reflux, extraction was started at a reflux ratio (reflux:distillation = 10 s:5 s), keeping the temperature at the top of the tower below 20 °C. During extraction, the oil bath temperature was increased to 50°C at a rate of 5°C/30 min. When the bottom temperature reached 42°C, HFA/HF recovery was stopped, the extraction was completed, the oil bath was removed, and the bottom was cooled to below 20°C in an ice bath. After cooling, the bottom residue was transferred by nitrogen pressure to a polyethylene vessel containing 900 g of water to precipitate the solids. The precipitate was filtered and washed twice with about 450 g of water to give bisphenol AF with a purity of 99.1%.After drying, the yield of bisphenol AF was 95.0%. The recovered distillate weighed 179.0 g and was analyzed to show the presence of 147.8 g of HF and 32.3 g of HFA, with 66.7% recovery of HF and 84.8% recovery of HFA based on the initial addition. The COD value of the wash water was determined to be 9413 mg/L according to JIS K 0102.

References

[1] Patent: JP5668319, 2015, B2. Location in patent: Paragraph 0021; 0042-0056
[2] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1960, # 4, p. 647 - 653
[3] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1960, # 4, p. 686 - 692
[4] Journal of the American Chemical Society, 2007, vol. 129, # 44, p. 13691 - 13697

Bisphenol AF Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Bisphenol AF manufacturers

CHINATECH(TIANJIN) CHEMICAL CO.,LTD.

Product: Bisphenol AF 1478-61-1
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: ≥99.5%
Supply Ability: 100MT
Release date: 2025-10-27

Hebei Chuanghai Biotechnology Co., Ltd

Product: Hexafluorobisphenol A 1478-61-1
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5tons
Release date: 2024-12-04

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Hexafluorobisphenol A 1478-61-1
Price: US $70.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-05-28

1478-61-1, Bisphenol AFRelated Search:

Bis(4-hydroxyphenyl) Sulfone 4,4'-Sulphonylbis(2,6-dibromophenol) Epichlorohydrin 9,9-Bis(4-hydroxyphenyl)fluorene 4,4'-DIHYDROXYDIPHENYLMETHANE 1,1'-Bi-2-naphthol Pentadecafluorooctanoic acid Phenol Propane Phthalic anhydride BISPHENOL A DIGLYCIDYL ETHER RESIN Hexamethylphosphoramide N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide Ammonium hexafluorophosphate 2,2-Bis(3-amino-4-hydroxyphenyl)hexafluoropropane Hexafluorobisphenol A Hexafluoroacetone PERFLUOROPROPANE

4,4'-(HEXAFLUOROISOPROPYLIDENE)DIPHEOL

2,2-BIS(4-HYDROXYPHENYL)HEXAFLUOROPROPANE

TIMTEC-BB SBB001375

HexafluorophenolA

BISPHENOL AF-M

BPAF

2,2-BIS(PARA-HYDROXYPHENYL)PERFLUOROPROPANE

BPAF(Bisphenol AF)

2,2-bis(4-hydroxyphenyl)hexafluoropane

4,4''-(PERFLUOROPROPANE-2,2-DIYL)DIPHENOL

2,2-Bis(4-hydroxyphenyl)hexafluoropropane 98%

2,2-Bis(4-hydroxyphenyl)hexafluoropropane98%

2,2-Bis(4-hydroxyphenyl)hexafluoropropane, Bisphenol AF, Hexafluorobisphenol A

4,4'-(Hexafluoroisopropylidene)diphenol,97%

4-[1,1,1,3,3,3-Hexafluoro-2-(4-hydroxyphenyl)propan-2-yl]phenol

1,1,1,3,3,3-Hexafluoro-2,2-bis(4-hydroxyphenyl)propane

1-[3-[(6-acetyl-3,5,7-trihydroxy-2,2-dimethyl-3,4-dihydro-2H-1-benzopyran-8-yl)methyl]-2,6-dihydroxy-4-methoxy-5-methylphenyl]ethanone

Bisphenol AF/Hexafluorobisphenol A

4,4'(Hexafluoroisopropylidene)dipnehol

2,2&prime

-Tetrahydroxybenzophenone-d4

2,2-bis(4-hydroxy-phenyl)-1,1,1,3,3,3-hexafluoropropane

3,3’-(hexafluoroisopropylidene)diphenol

4,4’-(2,2,2-trifluoro-1-(trifluoromethyl)ethylidene)bis-pheno

4,4’-(bis(trifluoromethyl)methylene)di-Phenol

4,4’-(trifluoro-1-(trifluoromethyl)ethylidene)di-pheno

4,4’-(trifluoro-1-(trifluoromethyl)ethylidene)diphenol

4,4’-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-pheno

4,4’-[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bisphenol

4,4’-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-Phenol

biphenolaf

hexafluoroacetonebisphenola

hexafluorodiphenylolpropane

Phenol,4,4’-(bis(trifluoromethyl)methylene)di-

Phenol,4,4’-[2,2,2-trifluoro-1-(trifluoromethyl)ethylidene]bis-

BIS-AF

BISPHENOL AF

BISPHENOL A HEXAFLUORIDE

HEXAFLUOROACETONE BISPHENOL

HEXAFLUOROBISPHENOL A

HEXAFLUOROISOPROPYLIDENEBIS(4-HYDROXYBENZENE)

DAIKIN YZ0001

4,4'-(HEXAFLUOROISOPROPYLIDENE)DIPHENOL

LABOTEST-BB LT00847967

2,2-BIS (4-HYDROXYPH

Hexafluorobisphenol A, 4,4'-(Perfluoropropan-2,2-diyl)diphenol

4,4zzhlxy-(Hexafluoroisopropylidene)diphenol (Bisphenol AF)

4-[1,2,2,3,3,3-hexafluoro-1-(4-hydroxyphenyl)propyl]phenol

4,4'-(Hexafluoroisopropylidene)diphenol, 4,4'-(1,1,1,3,3,3-Hexafluoropropane-2,2-diyl)diphenol

-(Hexafluoroisopropylidene)diphenol

4,4&priMe

Bisphenol AF Bisphenol A Hexafluoride Hexafluorobisphenol A 4,4'-(Hexafluoroisopropylidene)diphenol

AF4,4′-(Hexafluoroisopropylidene

4,4'-(Hexafluoroisopropylidene)diphenol 97%

4,4'-(Hexafluoroisopropylidene)diphenol, >=99.5%

2-Bis(4-hydroxyphenyl)hexafluoropropane

-Di-tert-butylphosphine)biphenylpalladium(II) Acetate

-Thiodiacetic Acid-13C4