VISNAGIN
- Product Name
- VISNAGIN
- CAS No.
- 82-57-5
- Chemical Name
- VISNAGIN
- Synonyms
- VISNAGIN;visnagine;visnagidin;VISNAGIN(P);VISNAGIN(RG);Metofuroxime;desmethoxykhellin;VISNAGIN USP/EP/BP;LABOTEST-BB LT00441024;4-Methoxy-7-methyl-5H-furo
- CBNumber
- CB5434295
- Molecular Formula
- C13H10O4
- Formula Weight
- 230.22
- MOL File
- 82-57-5.mol
VISNAGIN Property
- Melting point:
- 139-142 °C
- Boiling point:
- 292.2°C (rough estimate)
- Density
- 1.1302 (rough estimate)
- refractive index
- 1.4300 (estimate)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
- form
- Fine Crystalline Powder
- color
- Beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
- LogP
- 2.260 (est)
- CAS DataBase Reference
- 82-57-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T341649
- Product name
- VISNAGIN
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $179
- Updated
- 2024/03/01
- Product number
- V675008
- Product name
- Visnagin
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FV42573
- Product name
- Visnagin
- Packaging
- 5G
- Price
- $100
- Updated
- 2021/12/16
- Product number
- orb546235
- Product name
- Visnagin
- Purity
- >98%
- Packaging
- 25mg
- Price
- $127.5
- Updated
- 2021/12/16
- Product number
- FV42573
- Product name
- Visnagin
- Packaging
- 10g
- Price
- $175
- Updated
- 2021/12/16
VISNAGIN Chemical Properties,Usage,Production
Description
Visnagin (82-57-5) is a natural product isolated from the plant Ammi visnaga.? It displays protective effects against doxorubicin-induced cardiomyopathy via inhibition of mitochondrial malate dehydrogenase resulting in a decrease in cardiomyocyte apoptosis.1
Chemical Properties
BEIGE FINE CRYSTALLINE POWDER
Uses
antiinflammatory, neuroprotective
Definition
ChEBI: Visnagin is a furanochromone that is furo[3,2-g]chromen-5-one which is substituted at positions 4 and 7 by methoxy and methyl groups, respectively. Found in the toothpick-plant, Ammi visnaga. It has a role as a phytotoxin, an EC 1.1.1.37 (malate dehydrogenase) inhibitor, a vasodilator agent, an antihypertensive agent, an anti-inflammatory agent and a plant metabolite. It is a furanochromone, an aromatic ether and a polyketide. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.
Purification Methods
Crystallise visnagin from water. It is soluble in CHCl3 but slightly soluble in EtOH. [Aneja et al. Tetrahedron 3 230 1958, Beilstein 19 III/IV 2640.]
References
1) Liu et al. (2014), Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase; Sci. Transl. Med. 6 266ra170