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Ammonium thioglycolate

Product Name
Ammonium thioglycolate
CAS No.
5421-46-5
Chemical Name
Ammonium thioglycolate
Synonyms
ATG;usafmo-2;Perm salt;thiofacoa-50;Hair waving agent;(ca. 60% in Water);Ammoniumthioglykolat;Hair waving agent 95%;AMMONIUM THIOGLYCOLATE;AMMONIUM THIOGLYCOLLATE
CBNumber
CB5445341
Molecular Formula
C2H7NO2S
Formula Weight
109.15
MOL File
5421-46-5.mol
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Ammonium thioglycolate Property

Melting point:
139-139.5 °C
Boiling point:
115℃[at 101 325 Pa]
Density 
1.22
vapor pressure 
0.001Pa at 25℃
form 
Solution
Specific Gravity
1.245 (25℃)
color 
Clear colorless
Odor
strong skunk-like odor
Water Solubility 
Miscible
InChI
InChI=1S/C2H4O2S.H3N/c3-2(4)1-5;/h5H,1H2,(H,3,4);1H3
InChIKey
JYAVWXRMOOCSOD-UHFFFAOYSA-N
SMILES
C([O-])(=O)CS.[NH4+]
LogP
-2.99 at 20℃
CAS DataBase Reference
5421-46-5(CAS DataBase Reference)
EPA Substance Registry System
Acetic acid, 2-mercapto-, ammonium salt (1:1) (5421-46-5)
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Safety

Hazard Codes 
T
Risk Statements 
25-43
Safety Statements 
36/37-45-37-24
RIDADR 
2810
WGK Germany 
1
RTECS 
AI7525000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29309090
Hazardous Substances Data
5421-46-5(Hazardous Substances Data)
Toxicity
LD50 ipr-rat: 165 mg/kg JPETAB 97,349,49
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H301Toxic if swalloed

H317May cause an allergic skin reaction

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
10010
Product name
Ammonium thioglycolate solution
Purity
~60% in H2O
Packaging
1l
Price
$84.9
Updated
2024/03/01
TCI Chemical
Product number
A2217
Product name
Ammonium Thioglycolate (ca. 60% in Water)
Packaging
25g
Price
$19
Updated
2024/03/01
TCI Chemical
Product number
A2217
Product name
Ammonium Thioglycolate (ca. 60% in Water)
Packaging
500g
Price
$35
Updated
2024/03/01
TRC
Product number
A634080
Product name
AmmoniumThioglycolate
Packaging
2.5g
Price
$120
Updated
2021/12/16
TRC
Product number
A634080
Product name
AmmoniumThioglycolate
Packaging
10g
Price
$140
Updated
2021/12/16
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Ammonium thioglycolate Chemical Properties,Usage,Production

Description

Ammonium thioglycolate, also known as perm salt, is the chemical compound with the formula HSCH2CO2NH4. Being the salt of a weak acid and weak base, ammonium thioglycolic acid exists in solution as an equilibrium mixture of the salt itself as well as the free carboxylic acid thioglycolic acid (HSCH2CO2H) and ammonia : HSCH2COO- + NH4+ ? HSCH2COOH + NH3.

Chemical Properties

Clear colorless solution with characteristic odor

Uses

acts as a reducing agent in permanent-waving formulations for hair treatment and in shrink-resistant treatment of wool.

Uses

Ammonium thioglycolate is contained in permanent waves solutions and causes contact dermatitis in hairdressers.

Uses

Solutions of various strengths are used for hair waving and for hair removal.

Definition

ChEBI: Ammonium thioglycolate is an organic ammonium salt having thioglycolate(1-) as the counterion. Also known as perm salt, it has use in perming hair. It has a role as a reducing agent and an allergen. It contains a thioglycolate(1-).

General Description

Colorless to faint pink liquid with a repulsive, skunk-like odor.

Air & Water Reactions

Water soluble.

Reactivity Profile

Ammonium thioglycolate may be sensitive to heat. Ammonium thioglycolate is incompatible with acids.

Health Hazard

Exposure to this compound may cause sensitivity dermatitis of scalp or hands, with edema, erythema, subcutaneous lesions, burning of skin, papular rash and itching. It may also cause hypoglycemia. Other symptoms include central nervous system depression, convulsions and dyspnea.

Fire Hazard

Flash point data for Ammonium thioglycolate are not available. Ammonium thioglycolate is combustible.

Flammability and Explosibility

Not classified

Contact allergens

This substance is contained in “basic” permanent waves solutions and causes contact dermatitis in hairdressers.

Safety Profile

Poison by intravenous and intraperitoneal routes. An allergen; can cause contact dermatitis. Emits hydrogen sulfide. See also SULFIDES. When heated to decomposition it emits very toxic NOx, SOx, and NH3.

Chemical concepts related to perms

When discussing the chemistry of perms, one should consider two chemical facts. First is the thiol-disulfide equilibrium:
RSH + R'SSR' ? R'SH + RSSR'
where R and R' are organic substituents such as methyl (-CH3), ethyl (-C2H5), or -CH2COO-.
The thiol-disulfide exchange reaction is accelerated by bases such as ammonia, because the base generates some thiolate anion (RS- ), which attacks the disulfide. Thus the ammonia plays multiple roles (and more, see below) in this application.
The second chemical fact is that polar molecules are less volatile than nonpolar ones. So the glycolate substituent makes the thiol nonvolatile and hence non-odorous. An added advantage is that the glycolate confers some solubility in water. One could almost certainly use HSCH3 and ammonia to give a perm, but there would be serious olfactory consequences.

The actual chemistry of perms

A solution containing ammonium thioglycolate contains a lot of free ammonia, which swells hair, rendering it permeable. The thioglycolic acid in the perm solution reduces the disulfide cystine bonds in the cortex of the hair. In a sense, the thioglycolate removes crosslinks. After washing, the hair is treated with a mild solution of hydrogen peroxide, which oxidizes the cysteines back to cystine. These new chemical bonds impart the structural rigidity necessary for a successful perm. The rigidification process is akin to the vulcanization of rubber, where commonly polysulfide linkages are used to crosslink the polymer chains. However, not as many disulfide bonds are reformed as there were before the permanent. As a result, the hair is weaker than before the permanent was applied and repeated applications over the same spot may eventually cause strand breakage.

Ammonium thioglycolate Preparation Products And Raw materials

Raw materials

Thioglycolic acid Sodium bicarbonate

Preparation Products

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Ammonium thioglycolate Suppliers

Americas 1 Australia 2 Belgium 2 China 188 Europe 3 France 1 Germany 8 India 10 Italy 2 Japan 8 Jordan 1 Switzerland 1 United Kingdom 5 United States 19 USA 1 Global 252
Aladdin Scientific
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Evans Chemetics LP
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50
N&M Specialty Chemicals
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Evans Chemetics LP
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First Continental International (FCI)
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Alichem Inc.
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Robinson Brothers Limited
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OChem Incorporation
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United States Biological
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Riedel-de Haen AG
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TCI America
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Interchim Inc.
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HONEST JOY HOLDINGS LIMITED
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City Chemical LLC
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MP Biomedicals, Inc.
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City Chemicals Corporation
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Dow Chemical Company
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Eastern Chemical Corp.
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Pfaltz & Bauer, Inc.
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View Lastest Price from Ammonium thioglycolate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Ammonium thioglycolate 5421-46-5
Price
US $50.00/kg
Min. Order
1kg
Purity
60%
Supply Ability
20ton
Release date
2024-04-22
Shandong Deshang Chemical Co., Ltd.
Product
Ammonium thioglycolate 5421-46-5
Price
US $10.00-7.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-07-15
Hebei Yanxi Chemical Co., Ltd.
Product
?Ammonium thioglycolate 5421-46-5
Price
US $0.00/KG
Min. Order
1KG
Purity
40% 60% 70%
Supply Ability
200MT/Month
Release date
2024-04-03

5421-46-5, Ammonium thioglycolate Related Search:

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