Uses Reactions
ChemicalBook > CAS DataBase List > 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL

2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL

Uses Reactions
Product Name
2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
CAS No.
564483-19-8
Chemical Name
2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
Synonyms
tBuXPhos;t-Bu XPhos;t-butyl-Xphos;tBuXPhos 97%;2‘98% tBuXPhos;di-t-Bu-XPhos;2-Di-tert-butyL;TERT-BUTYL X-PHOS;2-Di-t-butylphosphino-2',4',6'
CBNumber
CB5451245
Molecular Formula
C29H45P
Formula Weight
424.64
MOL File
564483-19-8.mol
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2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Property

Melting point:
148-151 °C(lit.)
Boiling point:
493.5±45.0 °C(Predicted)
solubility 
soluble in Toluene
form 
Crystalline Powder
color 
White
InChI
InChI=1S/C29H45P/c1-19(2)22-17-24(20(3)4)27(25(18-22)21(5)6)23-15-13-14-16-26(23)30(28(7,8)9)29(10,11)12/h13-21H,1-12H3
InChIKey
SACNIGZYDTUHKB-UHFFFAOYSA-N
SMILES
P(C(C)(C)C)(C(C)(C)C)C1=CC=CC=C1C1=C(C(C)C)C=C(C(C)C)C=C1C(C)C
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
WGK Germany 
3
TSCA 
No
HS Code 
29310099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
901904
Product name
tBuXPhos
Purity
95%
Packaging
1G
Price
$61.4
Updated
2024/03/01
Sigma-Aldrich
Product number
638080
Product name
tBuXPhos
Purity
97%
Packaging
1g
Price
$57.4
Updated
2024/03/01
Sigma-Aldrich
Product number
901904
Product name
tBuXPhos
Purity
95%
Packaging
5G
Price
$142.8
Updated
2024/03/01
Sigma-Aldrich
Product number
638080
Product name
tBuXPhos
Purity
97%
Packaging
5g
Price
$184
Updated
2024/03/01
Sigma-Aldrich
Product number
901904
Product name
tBuXPhos
Purity
95%
Packaging
25G
Price
$420
Updated
2024/03/01
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2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Chemical Properties,Usage,Production

Uses

tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. tBuXPhos has been used in the preparation of [tBuXPhosAu(MeCN)]BAr4F, a gold catalyst for the intermolecular [2+2] cycloaddition of terminal arylalkynes with substituted alkenes to form functionalized cyclobutenes with high regioselectivity.
tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.
It can be used in the following reactions:
• Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
• Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
• Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones.

Reactions

  • Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles.
  • Ligand used in the Pd-catalyzed synthesis of phenols from aryl halides and KOH.
  • Ligand used in the Pd-catalyzed of benzoic acids from aryl halides and CO2.
  • Ligand used in the Pd-catalyzed trifluoromethylation of vinyl sulfonates.
  • Ligand used in the Pd-catalyzed arylation of nitroacetates.
  • Ligand used in the Pd-catalyzed Suzuki−Miyaura cross-coupling of allylboronates and aryl halides.
  • Ligand used in the Pd-catalyzed cyanation of (hetero)arylchlorides and bromides.
  • Ligand used in the Pd-catalyzed C–N cross coupling of sulfinamides and aryl halides.
  • Ligand used in the Pd-catalyzed arylation of cyanamides. 
 

Chemical Properties

White to pale yellow

Uses

Effective ligand for the Pd-catalyzed arylation of pyrazoles, indazoles and amino heterocycles

Uses

tBuXPhos is a ligand for Pd-catalyzed C-O and C-N bond formation.
It can be used in the following reactions:

  • Palladium-catalyzed Tsuji-Trost substitution and cross-coupling of benzylic fluorides.
  • Palladium-catalyzed C-N cross-coupling of sulfinamides and aryl halides.
  • Palladium-catalyzed rapid methoxylation and deuteriomethoxylation of bromo-chalcones.

Uses

suzuki reaction

General Description

tBuXPhos [2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Preparation Products And Raw materials

Raw materials

2-Bromopropane 2-Chloro-2-methylpropane Carbon tetrachloride Aluminum chloride Phosphorus trichloride 1,2-Dibromoethane Tetrahydrofuran 1,2-Dibromobenzene Benzene Ethyl acetate Copper(I) chloride Government regulation Dichloromethane Iron Magnesium

Preparation Products

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2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL Suppliers

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View Lastest Price from 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL manufacturers

Speranza Chemical Co., Ltd.
Product
2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL 564483-19-8
Price
US $0.00-0.00/KG
Min. Order
25KG
Purity
98%
Supply Ability
25KG
Release date
2024-01-05
XINXIANG RUNYU MATERIAL CO., LTD.
Product
2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl 564483-19-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
0.99
Supply Ability
500kg
Release date
2021-11-29
Shanghai UCHEM Inc.
Product
2-Di-tert-butylphosphino-2',4',6'-triisopropylbiphenyl 564483-19-8
Price
US $11.20-184.00/g
Min. Order
1g
Purity
0.98
Supply Ability
20kg
Release date
2023-10-25

564483-19-8, 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYLRelated Search:

2-DICYCLOHEXYLPHOSPHINO-2',6'-DIISOPROPOXYBIPHENYL 2-(Dicyclohexylphosphino)-2'-methylbiphenyl 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl 2-(Dicyclohexylphosphino)biphenyl 2'-(dicyclohexylphosphino)-6-methoxy-N,N-dimethylbiphenyl-2-amine 2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl 2-(Dicyclohexylphosphino)-2'-methoxybiphenyl 2-(Dicyclohexylphosphino)-3,6-dimethoxy-2'-4'-6'-tri-i-propyl-1,1'-biphenyl, min. 98% BrettPhos X-PHOS 2-Dicyclohexylphosphino-2',6'-bis(diMethylaMino)-1,1'-biphenyl, Min. 98% Cphos Tri-tert-butylphosphine tetrafluoroborate 2-(Di-tert-butylphosphino)biphenyl 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL 2-(DI-T-BUTYLPHOSPHINO)-2'-METHYLBIPHENYL DI-TERT-BUTYLPHENYLPHOSPHINE 2-DI-TERT-BUTYLPHOSPHINO-3,4,5,6-TETRAM&

  • 2-DI-T-BUTYLPHOSPHINO-2',4',6'-TRI-I-PROPYL-1,1'-BIPHENYL
  • 2-Di-tert-butylphosphino-2',4',6'-trisopropylbinphenyl
  • tBuXPhos 97%
  • 2-Di-tert-butyL
  • phosphino-2',4',6'-triisopropyL
  • phosphine, bis(1,1-diMethylethyl)[2',4',6'-tris(1-Methylethyl)[1,1'-biphenyl]-2-yl]-
  • t-Bu XPhos
  • tBuXPhos
  • Bis(1,1-dimethylethyl)[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine
  • 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
  • TERT-BUTYL X-PHOS
  • 2-DI-TERT-BUTYLPHOSPHINO-2',4', 6'-TRI-I-PROPYL-1,1'-BIPHENYL
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl,min.98%
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl,min.98%t-butylXPhos
  • 2-Di-tert-butylphosphino-2',4',6'-triisopropylbiphenyl ,98%
  • 2-Di-tert-butylphosphino-2′,4′,6′-triisopropylbiphenyl,tert-Butyl XPhos
  • 2-DI-T-BUTYLPHOSPHINO-2'',4'',6''-TRI-I-PROPYL-1,1''-BIPHENYL, MIN. 98%
  • t-butyl-Xphos
  • 2-di-tert-butylphosphino-2',4',6'-triisopropylbiph
  • 98% tBuXPhos
  • Di-tert-butyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine
  • di-t-Bu-XPhos
  • Di-tert-butyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine
  • 2-Di-t-butylphosphiNA-2',4',6'-tri-i-propyl-1,1'-biphenyl
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl, t-butylXPhos
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl, Min. 98% t-Bu-X-PHOS
  • 2-Di-t-butylphosphino-2',4',6'
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl,98% tBuXPhos
  • 2&lsquo
  • -DI-Tert-Butylphosphino-2,4,6-Triisopropylbiphenyl
  • phosphine, bis(1,1-diMethylethyl)[2',4',6'-tris(1-Methylethyl)[1,1'-biphenyl]
  • phosphine, bis(1,1-diMethylethyl)[2',4',6'-tris(1-Methylethyl)[1,1'-biphen
  • 2-(Di-t-butylphosphino)-2',4',6'-tri- i-propyl-1,1'-biphenyl (tBu-Xphos)
  • Di-tert-butyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine 98%
  • tBuXPhos / 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl
  • 2-Di-t-butylphosphino-2',4',6'-tri-isopropyl-1,1'-biphenyl
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propylbiphenyl
  • 2-Di-tert-butyphosphino-2',4',6'-trisopropyl-1,1'-biphenyl
  • phosphine, bis(1,1-dimethylethyl)[2',4',6'-tris(1-methylethy...
  • 564483-19-8 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
  • di-tert-butyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane
  • 2-Di-t-butylphosphino-2’,4’,6’-triisopropyl-1,1’-biphenyl (tBuXPhos)
  • 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIPHENYL
  • Di-tert-butyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphine
  • Bis(1,1-dimethylethyl)[2',4',6'-tris(1-methylethyl)[1,1'-biphenyl]-2-yl]phosphine
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl
  • di-tert-butyl(2',4',6'-triisopropyl-[1,1'-biphenyl]-2-yl)phosphane
  • 2-Di-tert-butylphosphino-2',4',6'-trisopropylbinphenyl
  • 2-Di-t-butylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl, tBuXPhos
  • 2-DI-TERT-BUTYLPHOSPHINO-2',4',6'-TRIISOPROPYLBIP
  • 564483-19-8
  • C29H45P
  • Achiral Phosphine
  • Aryl Phosphine
  • Buchwald Ligands Series
  • Buchwald Ligands&Precatalysts