ChemicalBook > CAS DataBase List > AZODICARBOXYLIC BISMORPHOLIDE

AZODICARBOXYLIC BISMORPHOLIDE

Product Name
AZODICARBOXYLIC BISMORPHOLIDE
CAS No.
10465-82-4
Chemical Name
AZODICARBOXYLIC BISMORPHOLIDE
Synonyms
NSC 356022;AZODICARBOXYLIC DIMORPHOLIDE;AZODICARBOXYLIC BISMORPHOLIDE;4,4'-Azodicarbonylbis(morpholine);Azodicarboxylic dimorpholide >=98.0% (N);Diazene-1,2-diylbis(morpholinomethanone);Methanone,1,1'-(1,2-diazenediyl)bis[1-(4-morpholinyl)-;Methanone,1,1'-(1,2-diazenediyl)bis[1-(4-morpholinyl)-
CBNumber
CB5454231
Molecular Formula
C10H16N4O4
Formula Weight
256.26
MOL File
10465-82-4.mol
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AZODICARBOXYLIC BISMORPHOLIDE Property

Melting point:
141-143 °C
Boiling point:
397.6±52.0 °C(Predicted)
Density 
1.46±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
-0.97±0.20(Predicted)
Appearance
Light yellow to yellow Solid
BRN 
1013753
InChI
InChI=1S/C10H16N4O4/c15-9(13-1-5-17-6-2-13)11-12-10(16)14-3-7-18-8-4-14/h1-8H2
InChIKey
CHAMTJKQPOMXTI-UHFFFAOYSA-N
SMILES
N(C(N1CCOCC1)=O)=NC(N1CCOCC1)=O
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
11628
Product name
Azodicarboxylic dimorpholide
Purity
≥98.0% (N)
Packaging
5g
Price
$173.5
Updated
2025/07/31
Matrix Scientific
Product number
100010
Product name
Diazene-1,2-diylbis(morpholinomethanone)
Purity
95+%
Packaging
1g
Price
$284
Updated
2021/12/16
Matrix Scientific
Product number
100010
Product name
Diazene-1,2-diylbis(morpholinomethanone)
Purity
95+%
Packaging
5g
Price
$840
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0117295
Product name
AZODICARBOXYLIC DIMORPHOLIDE
Purity
95.00%
Packaging
5G
Price
$914.41
Updated
2021/12/16
AK Scientific
Product number
1041AA
Product name
Diazene-1,2-diylbis(morpholinomethanone)
Packaging
1g
Price
$91
Updated
2021/12/16
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AZODICARBOXYLIC BISMORPHOLIDE Chemical Properties,Usage,Production

Uses

Azodicarboxylic dimorpholide has been used in the galanthamine ring system reaction that utilizes an intramolecular Heck reaction to establish the benzofuran ring system. Galanthamine exhibits potent acetylcholinesterase inhibitory activity and is important in the management of Alzheimer′s disease.

General Description

Azodicarboxylic dimorpholide is a yellow to dark yellow powder or crystals

Synthesis

110-91-8

1972-28-7

10465-82-4

To a stirred mixture of diethyl azodicarboxylate (40 wt% toluene solution, 5 mL, 11.5 mmol, 1 eq.) and ether (25 mL) was slowly added an ether solution (25 mL) of morpholine (1.98 mL, 23 mmol, 2 eq.) through a dropping funnel at 0 °C, the dropwise addition process continued for 3 hours. The reaction mixture was then continued to stir for 2 hours under slow warming to room temperature. The resulting yellow precipitate was collected by vacuum filtration, washed with cold ether and dried over a filter to afford azodicarbonyl dimorpholine (ADDM) as a yellow-orange solid (1.62 g, 55% yield). The NMR hydrogen spectrum (CDCl3, 400 MHz) data were as follows: δ 3.61 (multiple peaks, 4H, 2 × CH2), 3.74 (multiple peaks, 8H, 4 × CH2), 3.83 (multiple peaks, 4H, 2 × CH2).

References

[1] Tetrahedron Letters, 2013, vol. 54, # 35, p. 4624 - 4628

AZODICARBOXYLIC BISMORPHOLIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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AZODICARBOXYLIC BISMORPHOLIDE Suppliers

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View Lastest Price from AZODICARBOXYLIC BISMORPHOLIDE manufacturers

Career Henan Chemical Co
Product
AZODICARBOXYLIC BISMORPHOLIDE 10465-82-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2018-08-06

10465-82-4, AZODICARBOXYLIC BISMORPHOLIDERelated Search:

N,N,N',N'-Tetramethylazodicarboxamide Diisopropyl azodicarboxylate 1,1'-(Azodicarbonyl)-dipiperidine Di-tert-Butyl azodicarboxylate Diethyl azodicarboxylate Dibenzyl azodicarboxylate Morpholinazole N-Formylmorpholine N-(2-METHOXYETHYL)UREA AZODICARBOXYLIC BISMORPHOLIDE Azodicarbonamide C-MORPHOLIN-4-YL-METHYLAMINE

  • AZODICARBOXYLIC BISMORPHOLIDE
  • AZODICARBOXYLIC DIMORPHOLIDE
  • 4,4'-Azodicarbonylbis(morpholine)
  • Diazene-1,2-diylbis(morpholinomethanone)
  • Azodicarboxylic dimorpholide >=98.0% (N)
  • NSC 356022
  • Methanone,1,1'-(1,2-diazenediyl)bis[1-(4-morpholinyl)-
  • Methanone,1,1'-(1,2-diazenediyl)bis[1-(4-morpholinyl)-
  • 10465-82-4
  • Heterocyclic Building Blocks
  • Morpholines
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