ChemicalBook > CAS DataBase List > 2,2-Difluorobenzodioxole-5-carboxylic acid

2,2-Difluorobenzodioxole-5-carboxylic acid

Product Name
2,2-Difluorobenzodioxole-5-carboxylic acid
CAS No.
656-46-2
Chemical Name
2,2-Difluorobenzodioxole-5-carboxylic acid
Synonyms
BUTTPARK 29\01-69;RARECHEM AL BO 0906;2,2-Difluoro-1,3-benzodioxole-5-ca;5-Carboxy-2,2-difluoro-1,3-benzodioxole;2,2-Difluorobenzodioxole-5-carboxylic acid;2,2-difuoro-[1,3]-benzodioxole-5-carboxy acid;2,2-DIFLUORO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID;2,3-Difluoro-1,3-benzodioxole-5-carboxylic acid;1,3-Benzodioxole-5-carboxylicacid, 2,2-difluoro-;2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid98%
CBNumber
CB5457823
Molecular Formula
C8H4F2O4
Formula Weight
202.11
MOL File
656-46-2.mol
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2,2-Difluorobenzodioxole-5-carboxylic acid Property

Melting point:
178
Boiling point:
266.1±40.0 °C(Predicted)
Density 
1.66±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.01±0.40(Predicted)
color 
White to Off-White
CAS DataBase Reference
656-46-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36
Hazard Note 
Irritant
HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D445583
Product name
2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid
Packaging
250mg
Price
$55
Updated
2021/12/16
SynQuest Laboratories
Product number
2H21-3-X4
Product name
2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid
Purity
98%
Packaging
1g
Price
$72
Updated
2021/12/16
Apolloscientific
Product number
PC4367
Product name
2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid
Purity
98%
Packaging
250mg
Price
$10
Updated
2021/12/16
SynQuest Laboratories
Product number
2H21-3-X4
Product name
2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid
Purity
98%
Packaging
250mg
Price
$16
Updated
2021/12/16
Matrix Scientific
Product number
082774
Product name
2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid
Purity
97%
Packaging
1g
Price
$120
Updated
2021/12/16
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2,2-Difluorobenzodioxole-5-carboxylic acid Chemical Properties,Usage,Production

Synthesis

773873-95-3

656-46-2

The general procedure for the synthesis of 2,2-difluoro-1,3-benzodioxole-5-carboxylic acid from methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate is as follows: Step 2. A solution of methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate (1.4 g, 6.48 mmol) and sodium hydroxide (830 mg, 20.75 mmol) in methanol (30 ml) was stirred at room temperature overnight. After completion of the reaction, the reaction mixture was concentrated under vacuum and subsequently dissolved in water (20 ml). The pH of the aqueous solution was adjusted to 3 with 3N HCl, at which point a precipitate was produced. The precipitate was collected by filtration to afford 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylic acid as a white solid (1.2 g, 92% yield). Product characterization data: 1H-NMR (300 MHz, DMSO) δ 13.23 (s, 1H, COOH), 7.85 (s, 1H, Ar-H), 7.53 (d, J=1.5 Hz, 1H, Ar-H), 7.53 (d, J=9.0 Hz, 1H, Ar-H).

References

[1] Patent: US2012/277224, 2012, A1. Location in patent: Page/Page column 26

2,2-Difluorobenzodioxole-5-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2,2-Difluorobenzodioxole-5-carboxylic acid manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2,2-Difluorobenzodioxole-5-carboxylic acid 656-46-2
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-06-24
Henan Fengda Chemical Co., Ltd
Product
2,2-Difluorobenzodioxole-5-carboxylic acid 656-46-2
Price
US $5.00-0.10/KG
Min. Order
1KG
Purity
98%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-08
Honest Joy Holdings Limited
Product
2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid 656-46-2
Price
US $0.00/KG
Min. Order
1KG
Purity
99.4%
Supply Ability
100 tons
Release date
2022-02-18

656-46-2, 2,2-Difluorobenzodioxole-5-carboxylic acidRelated Search:

Diethyl phthalate 3-(Trifluoromethyl)benzoic acid 1,2,3-Trifluoro-4-nitrobenzene Phenylmethylsulfonyl fluoride (Trifluoromethoxy)benzene Diisononyl phthalate Phthalic acid 3-(Trifluoromethyl)benzaldehyde Diisobutyl phthalate Bis(2-ethylhexyl) phthalate Ethyl 2-(Chlorosulfonyl)acetate Dimethyl phthalate Potassium hydrogen phthalate Isophthalic acid 4-Difluoromethoxy-3-hydroxybenzaldehyde 3-(DIFLUOROMETHOXY)BENZYL ALCOHOL 2-(DIFLUOROMETHOXY)PHENOL 98 2,2-Difluoro-1,3-benzodioxole

  • BUTTPARK 29\01-69
  • 2,2-DIFLUORO-1,3-BENZODIOXOLE-5-CARBOXYLIC ACID
  • RARECHEM AL BO 0906
  • 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid, 97+%
  • 5-Carboxy-2,2-difluoro-1,3-benzodioxole
  • 2,2-Difluoro-1,3-benzodioxole-5-carboxylic acid 98%
  • 2,2-Difluoro-1,3-benzodioxole-5-carboxylicacid98%
  • 2,3-Difluoro-1,3-benzodioxole-5-carboxylic acid
  • 2,2-Difluorobenzodioxole-5-carboxylic acid
  • 5-Carboxy-2,2-difluoro-1,3-benzodioxole, 3,4-(Difluoromethylenedioxy)benzoic acid
  • 2,2-difluoro-2H-1,3-benzodioxole-5-carboxylic acid
  • 1,3-Benzodioxole-5-carboxylicacid, 2,2-difluoro-
  • 2,2-difuoro-[1,3]-benzodioxole-5-carboxy acid
  • 2,2-Difluoro-1,3-benzodioxole-5-ca
  • 2,2-Difluoro6benzo[d][1,3]dioxole-5-carboxylic acid
  • 656-46-2
  • C8H3F2O4
  • Benzodiozoles, Benzodioxines & Benzodioxepines
  • Carboxylic Acids
  • Heterocycles series
  • Benzodiozoles, Benzodioxines & Benzodioxepines
  • Carboxylic Acids