ChemicalBook > CAS DataBase List > U-74389G

U-74389G

Product Name
U-74389G
CAS No.
153190-29-5
Chemical Name
U-74389G
Synonyms
METHYLATED TIRILAZAD;U-74389G;U74389G,U 74389G;(Z)-2-BUTENEDIONATE;DESMETHYL TIRILAZAD;U-74389G, Antioxidant;ABCSSKWSUJMJCP-WQDFMEOSSA-N;21-(4-(2,6 DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE;21-[4-(4,6-DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL]-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE MALEATE;21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]-triene-3,20-dione maleate salt
CBNumber
CB5461091
Molecular Formula
C41H54N6O6
Formula Weight
726.9
MOL File
153190-29-5.mol
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U-74389G Property

storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
ethanol: soluble20 mg/mL, clear, light yellow
form 
White solid.
color 
White
Sensitive 
Hygroscopic
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
U5882
Product name
U-74389G
Packaging
100mg
Price
$293
Updated
2025/07/31
Cayman Chemical
Product number
75860
Product name
U-74389G
Purity
≥99%
Packaging
50mg
Price
$72
Updated
2024/03/01
Cayman Chemical
Product number
75860
Product name
U-74389G
Purity
≥99%
Packaging
100mg
Price
$115
Updated
2024/03/01
Cayman Chemical
Product number
75860
Product name
U-74389G
Purity
≥99%
Packaging
250mg
Price
$266
Updated
2024/03/01
TRC
Product number
G932020
Product name
U-74389G
Packaging
100mg
Price
$95
Updated
2021/12/16
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U-74389G Chemical Properties,Usage,Production

Description

U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.

Uses

U-74389G is a potent inhibitor of superoxide-mediated lipid peroxidation.

in vivo

U-74389G (intravenous injection; 10 mg/kg; once daily; 6 d) treatment shows significant anti-inflammatory activity related to its ability to reduce colonic TNF-α, CMDI score, and improve weight change[2].
U-74389G (intravenous injection; 15 or 30 mg/kg) treatment significantly protects against lipopolysaccharide-induced lethality, reduces hypotension, ameliorates liver function, decreases plasma nitrite levels, restores the hyporeactivity of aortic rings to their control values and inhibits the activity of inducible NO synthase in the liver and in the aorta[3].

Animal Model:Rat model of trinitrobenzenesulfonic acid-induced colitis[2]
Dosage:10 mg/kg
Administration:Intravenous injection; 10 mg/kg; once daily; 6 d
Result:Reduced TNF-α, the macroscopic index of mucosal damage score (CMDI) and increased body weight.
Animal Model:Male Sprague–Dawley rats injected with Lipopolysaccharide[3]
Dosage:15 or 30 mg/kg
Administration:Intravenous injection; 15 or 30 mg/kg
Result:Protected against lipopolysaccharide-induced lethality (90% survival rate 24 h and 80% 72 h after Lipopolysaccharide injection, respectively, following the highest dose).

References

[1] J. BRAUGHLER. Novel 21-amino steroids as potent inhibitors of iron-dependent lipid peroxidation.[J]. The Journal of Biological Chemistry, 1987, 27 1: 10438-10440. DOI:10.1016/s0021-9258(18)60979-2
[2] G M CAMPO. Protection of ischemic and reperfused rat myocardium by the nonglucocorticoid 21-aminosteroid U-74389G, a new inhibitor of lipid peroxidation.[J]. Journal of Pharmacology and Experimental Therapeutics, 1996, 277 1: 333-340.
[3] A.M. PERNA . PROTECTION OF RAT HEART FROM ISCHAEMIA-REPERFUSION INJURY BY THE 21-AMINOSTEROID U-74389G[J]. Pharmacological research, 1996, 34 1: Pages 25-31. DOI:10.1006/phrs.1996.0059

U-74389G Preparation Products And Raw materials

Raw materials

Preparation Products

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U-74389G Suppliers

China 55 Switzerland 2 United Kingdom 1 United States 9 Global 67
TargetMol Chemicals Inc.
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United States Biological
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BIOMOL INTERNATIONAL, LP
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153190-29-5, U-74389GRelated Search:

Amlodipine 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid N-[4-[[1-[2-(6-METHYL-2-PYRIDINYL)ETHYL]-4-PIPERIDINYL]CARBONYL]PHENYL]METHANESULFONAMIDE DIHYDROCHLORIDE Iron Chelator, Dp44mT U 74389F 2-Pyrimidinamine,4-(1-piperazinyl)-(9CI) 2,4,6-Triaminopyrimidine 4-(PIPERAZIN-1-YL)-2,6-DI-(PYRROLIDIN-1-YL)-PYRIMIDINE U-74389G 1-(1-HEPTYL)-PIPERAZINE 4-AMINO-6-(4-METHYL-1-PIPERAZINYL)PYRIMIDINE 1-N-NONYLPIPERAZINE 1-DECYLPIPERAZINE 1-OCTYLPIPERAZINE

  • U-74389G
  • (Z)-2-BUTENEDIONATE
  • 21-(4-(2,6 DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE
  • 21-(4-(2,6 DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE (Z)-2-BUTENEDIONATE
  • 21-(4-(2,6-DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL)-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE (Z)-2-BUTENEDIOATE
  • 21-[4-(4,6-DI-1-PYRROLIDINYL-4-PYRIMIDINYL)-1-PIPERAZINYL]-PREGNA-1,4,9(11)-TRIENE-3,20-DIONE MALEATE
  • METHYLATED TIRILAZAD
  • DESMETHYL TIRILAZAD
  • 21-[4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl]pregna-1,4,9[11]-triene-3,20-dione maleate salt
  • ABCSSKWSUJMJCP-WQDFMEOSSA-N
  • (8S,10S,13S,14S,17S)-17-(2-(4-(2,6-Di(pyrrolidin-1-yl)pyrimidin-4-yl)piperazin-1-yl)acetyl)-10,13-dimethyl-6,7,8,10,12,13,14,15,16,17-decahydro-3H-cyclopenta[a]phenanthren-3-one maleate
  • U74389G,U 74389G
  • U-74389G, Antioxidant
  • 153190-29-5
  • C37H50N6O2C4H4O4